Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy von Long, Kimberly K, O'Shea, Karen M, Khairallah, Ramzi J, Howell, Kelly, Paushkin, Sergey, Chen, Karen S, Cote, Shaun M, Webster, Micah T, Stains, Joseph P, Treece, Erin, Buckler, Alan, Donovan, Adriana

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The early-onset torsion dystonia gene ( DYT1 ) encodes an ATP-binding protein von Ozelius, Laurie J, Hewett, Jeffrey W, Page, Curtis E, Bressman, Susan B, Kramer, Patricia L, Shalish, Christo, de Leon, Deborah, Brin, Mitchell F, Raymond, Deborah, Corey, David P, Fahn, Stanley, Risch, Neil J, Buckler, Alan J, Gusella, James F, Breakefield, Xandra O

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Identification of Cardiac Glycoside Molecules as Inhibitors of c-Myc IRES-Mediated Translation von Didiot, Marie-Cecile, Hewett, Jeffrey, Varin, Thibault, Freuler, Felix, Selinger, Douglas, Nick, Hanspeter, Reinhardt, Juergen, Buckler, Alan, Myer, Vic, Schuffenhauer, Ansgar, Guy, Chantale T., Parker, Christian N.

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Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy von Harley, Helen G, Brook, J. David, Rundle, Shelley A, Crow, Stephen, Reardon, William, Buckler, Alan J, Harper, Peter S, Housman, David E, Shaw, Duncan J

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Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations von Walker, Simon A, Kupzig, Sabine, Bouyoucef, Dalila, Davies, Louise C, Tsuboi, Takashi, Bivona, Trever G, Cozier, Gyles E, Lockyer, Peter J, Buckler, Alan, Rutter, Guy A, Allen, Maxine J, Philips, Mark R, Cullen, Peter J

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Isolation of genes from complex sources of mammalian genomic DNA using exon amplification von Church, Deanna M, Stotler, Christy J, Rutter, Joni L, Murrell, Jill R, Trofatter, James A, Buckler, Alan J

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Inactivating Mutations in an SH2 Domain-Encoding Gene in X-Linked Lymphoproliferative Syndrome von Nichols, Kim E., Harkin, D. Paul, Levitz, Seth, Krainer, Michael, Kolquist, Kathryn Ann, Genovese, Cameo, Bernard, Amy, Ferguson, Martin, Zuo, Lin, Snyder, Eric, Buckler, Alan J., Wise, Carol, Ashley, Jennifer, Lovett, Michael, Valentine, Marcus B., Look, A. Thomas, Gerald, William, Housman, David E., Haber, Daniel A.

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Isolation of a novel gene underlying batten disease, CLN3 von Lerner, Terry J, Boustany, Rose-Mary N, Anderson, John W, D'Arigo, Kenneth L, Schlumpf, Karen, Buckler, Alan J, Gusella, James F, Haines, Jonathan L

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Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury ( T ) gene family von Young, Ian D, Robson, Stephen C, Bonnet, Damien, Bullen, Philip J, Newbury-Ecob, Ruth A, Gebuhr, Tom, Buckler, Alan J, Wilson, David I, Law, David J, Terrett, Jonathan A, Brook, J. David, Yi Li, Quan, Strachan, Tom, Curtis, Andrew R.J, Raeburn, J. Alexander, Lyonnet, Stanislas, Ho Yi, Cheong

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The Epithelium-specific ETS Protein EHF/ESE-3 Is a Context-dependent Transcriptional Repressor Downstream of MAPK Signaling Cascades von Tugores, Antonio, Le, Jennifer, Sorokina, Irina, Snijders, A.J., Duyao, Mabel, Reddy, P. Sanjeeva, Carlée, Leone, Ronshaugen, Mathew, Mushegian, Arcady, Watanaskul, Tim, Chu, Sunny, Buckler, Alan, Emtage, Spencer, McCormick, Mary Kay

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Identification and characterization of novel human transcripts embedded within HMGA2 in t(12; 14)(q15; q24.1) uterine leiomyoma von Ingraham, SE, Lynch, R A, Surti, U, Rutter, J L, Buckler, A J, Khan, SA, Menon, A G, Lepont, P

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Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member von Brook, J.David, McCurrach, Mila E., Harley, Helen G., Buckler, Alan J., Church, Deanna, Aburatani, Hiroyuki, Hunter, Kent, Stanton, Vincent P., Thirion, Jean-Paul, Hudson, Thomas, Sohn, Robert, Zemelman, Boris, Snell, Russell G., Rundle, Shelley A., Crow, Steve, Davies, June, Shelbourne, Peggy, Buxton, Jessica, Jones, Clare, Juvonen, Vesa, Johnson, Keith, Harper, Peter S., Shaw, Duncan J., Housman, David E.

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Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus von Call, Katherine M., Glaser, Tom, Ito, Caryn Y., Buckler, Alan J., Pelletier, Jerry, Haber, Daniel A., Rose, Elise A., Kral, Astrid, Yeger, Herman, Lewis, William H., Jones, Carol, Housman, David E.

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An antibody that inhibits TGF-β1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis von Jackson, Justin W, Frederick C Streich, Jr, Pal, Ajai, Coricor, George, Boston, Chris, Brueckner, Christopher T, Canonico, Kaleigh, Chapron, Christopher, Cote, Shaun, Dagbay, Kevin B, Danehy, Jr, Francis T, Kavosi, Mania, Kumar, Sandeep, Lin, Susan, Littlefield, Christopher, Looby, Kailyn, Manohar, Rohan, Martin, Constance J, Wood, Marcie, Zawadzka, Agatha, Wawersik, Stefan, Nicholls, Samantha B, Datta, Abhishek, Buckler, Alan, Schürpf, Thomas, Carven, Gregory J, Qatanani, Mohammed, Fogel, Adam I

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Exon Amplification: A Strategy to Isolate Mammalian Genes Based on RNA Splicing von BUCKLER, A. J, CHANG, D. D, GRAW, S. L, BROOK, J. D, HABER, D. A, SHARP, P. A, HOUSMAN, D. E

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Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies von Bernasconi-Elias, P, Hu, T, Jenkins, D, Firestone, B, Gans, S, Kurth, E, Capodieci, P, Deplazes-Lauber, J, Petropoulos, K, Thiel, P, Ponsel, D, Hee Choi, S, LeMotte, P, London, A, Goetcshkes, M, Nolin, E, Jones, M D, Slocum, K, Kluk, M J, Weinstock, D M, Christodoulou, A, Weinberg, O, Jaehrling, J, Ettenberg, S A, Buckler, A, Blacklow, S C, Aster, J C, Fryer, C J

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Abstract 4090: Defeating primary checkpoint resistance: SRTβ1-Ab3 is a first-in-class, fully human antibody that renders resistant tumors sensitive to anti-PD-1 von Schürpf, Thomas, Martin, Constance J., Littlefield, Christopher, Chapron, Christopher, Wawersik, Stefan, Kalra, Ashish, Simpson, Allison, Danehy, Francis, Boston, Christopher, Nikiforov, Anastasia, Lin, Susan, Jackson, Justin, Carven, Gregory J., Buckler, Alan, Datta, Abhishek

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NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models von Jensen, Michael Rugaard, Schoepfer, Joseph, Radimerski, Thomas, Massey, Andrew, Guy, Chantale T, Brueggen, Josef, Quadt, Cornelia, Buckler, Alan, Cozens, Robert, Drysdale, Martin J, Garcia-Echeverria, Carlos, Chène, Patrick

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CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling von Henry, Kate L, Kellner, Debra, Bajrami, Bekim, Anderson, John E, Beyna, Mercedes, Bhisetti, Govinda, Cameron, Tom, Capacci, Andrew G, Bertolotti-Ciarlet, Andrea, Feng, Jun, Gao, Benbo, Hopkins, Brian, Jenkins, Tracy, Li, Kejie, May-Dracka, Tricia, Murugan, Paramasivam, Wei, Ru, Zeng, Weike, Allaire, Norm, Buckler, Alan, Loh, Christine, Juhasz, Peter, Lucas, Brian, Ennis, Katelin A, Vollman, Elisabeth, Cahir-McFarland, Ellen, Hett, Erik C, Ols, Michelle L

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Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth von Harbinski, Fred, Craig, Vanessa J, Sanghavi, Sneha, Jeffery, Douglas, Liu, Lijuan, Sheppard, Kelly Ann, Wagner, Sabrina, Stamm, Christelle, Buness, Andreas, Chatenay-Rivauday, Christian, Yao, Yao, He, Feng, Lu, Chris X, Guagnano, Vito, Metz, Thomas, Finan, Peter M, Hofmann, Francesco, Sellers, William R, Porter, Jeffrey A, Myer, Vic E, Graus-Porta, Diana, Wilson, Christopher J, Buckler, Alan, Tiedt, Ralph

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