NF-κB RelA Phosphorylation Regulates RelA Acetylation von Chen, Lin-Feng, Williams, Samuel A., Mu, Yajun, Nakano, Hiroyasu, Duerr, James M., Buckbinder, Leonard, Greene, Warner C.

Volltext

Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition von Roth Flach, Rachel J, Su, Chunyan, Bollinger, Eliza, Cortes, Christian, Robertson, Andrew W, Opsahl, Alan C, Coskran, Timothy M, Maresca, Kevin P, Keliher, Edmund J, Yates, Phillip D, Kim, Albert M, Kalgutkar, Amit S, Buckbinder, Leonard

Volltext

Discovery of 2‑(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)‑yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for... von Ruggeri, Roger B, Buckbinder, Leonard, Bagley, Scott W, Carpino, Philip A, Conn, Edward L, Dowling, Matthew S, Fernando, Dilinie P, Jiao, Wenhua, Kung, Daniel W, Orr, Suvi T. M, Qi, Yingmei, Rocke, Benjamin N, Smith, Aaron, Warmus, Joseph S, Zhang, Yan, Bowles, Daniel, Widlicka, Daniel W, Eng, Heather, Ryder, Tim, Sharma, Raman, Wolford, Angela, Okerberg, Carlin, Walters, Karen, Maurer, Tristan S, Zhang, Yanwei, Bonin, Paul D, Spath, Samantha N, Xing, Gang, Hepworth, David, Ahn, Kay, Kalgutkar, Amit S

Volltext

Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Me... von Dong, Jennifer Q, Gosset, James R, Fahmi, Odette A, Lin, Zhiwu, Chabot, Jeffrey R, Terra, Steven G, Le, Vu, Chidsey, Kristin, Nouri, Parya, Kim, Albert, Buckbinder, Leonard, Kalgutkar, Amit S

Volltext

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design von Han, Seungil, Mistry, Anil, Chang, Jeanne S., Cunningham, David, Griffor, Matt, Bonnette, Peter C., Wang, Hong, Chrunyk, Boris A., Aspnes, Gary E., Walker, Daniel P., Brosius, Arthur D., Buckbinder, Leonard

Volltext

Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction von Ali, Muhammad, MD, Pulli, Benjamin, MD, Courties, Gabriel, PhD, Tricot, Benoit, MSc, Sebas, Matthew, BSc, Iwamoto, Yoshiko, BSc, Hilgendorf, Ingo, MD, Schob, Stefan, MD, Dong, Anping, MD, PhD, Zheng, Wei, MD, Skoura, Athanasia, PhD, Kalgukar, Amit, PhD, Cortes, Christian, MSc, Ruggeri, Roger, PhD, Swirski, Filip K., PhD, Nahrendorf, Matthias, MD, PhD, Buckbinder, Leonard, PhD, Chen, John W., MD, PhD

Volltext

Induction of the growth inhibitor IGF-binding protein 3 by p53 von Buckbinder, Leonard, Talbott, Randy, Velasco-Miguel, Susana, Takenaka, Ivone, Faha, Barbara, Seizinger, Bernd R, Kley, Nikolai

Volltext

B Cell Receptor-induced Phosphorylation of Pyk2 and Focal Adhesion Kinase Involves Integrins and the Rap GTPases and Is Required for B Cell Spreading von Tse, Kathy W.K., Dang-Lawson, May, Lee, Rosaline L., Vong, Doris, Bulic, Anica, Buckbinder, Leonard, Gold, Michael R.

Volltext

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes von VELASCO-MIGUEL, S, BUCKBINDER, L, JEAN, P, GELBERT, L, TALBOTT, R, LAIDLAW, J, SEIZINGER, B, KLEY, N

Volltext

Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning von Hedman, Åsa K, Hage, Camilla, Sharma, Anil, Brosnan, Mary Julia, Buckbinder, Leonard, Gan, Li-Ming, Shah, Sanjiv J, Linde, Cecilia M, Donal, Erwan, Daubert, Jean-Claude, Mälarstig, Anders, Ziemek, Daniel, Lund, Lars

Volltext

An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo von Wang, Cuihua, Keliher, Edmund, Zeller, Matthias W. G., Wojtkiewicz, Gregory R., Aguirre, Aaron D., Buckbinder, Leonard, Kim, Hye-Yeong, Chen, Jianqing, Maresca, Kevin, Ahmed, Maaz S., Motlagh, Negin Jalali, Nahrendorf, Matthias, Chen, John W.

Volltext

STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts von Buckbinder, Leonard, St Jean, Jr, David J, Tieu, Trang, Ladd, Brendon, Hilbert, Brendan, Wang, Weixue, Alltucker, Jacob T, Manimala, Samantha, Kryukov, Gregory V, Brooijmans, Natasja, Dowdell, Gregory, Jonsson, Philip, Huff, Michael, Guzman-Perez, Angel, Jackson, Erica L, Goncalves, Marcus D, Stuart, Darrin D

Volltext

An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo von Wang, Cuihua, Keliher, Edmund, G Zeller, Matthias W, Wojtkiewicz, Gregory R, Aguirre, Aaron D, Buckbinder, Leonard, Kim, Hye-Yeong, Chen, Jianqing, Maresca, Kevin, Ahmed, Maaz S, Motlagh, Negin Jalali, Nahrendorf, Matthias, Chen, John W

Volltext

The p53 Tumor Suppressor Targets a Novel Regulator of G Protein Signaling von Buckbinder, Leonard, Velasco-Miguel, Susana, Chen, Yan, Xu, Ningzhi, Talbott, Randy, Gelbert, Larry, Gao, Jizong, Seizinger, Bernd R., Gutkind, J. Silvio, Kley, Nikolai

Volltext

2‑Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety von Dow, Robert L, Ammirati, Mark, Bagley, Scott W, Bhattacharya, Samit K, Buckbinder, Leonard, Cortes, Christian, El-Kattan, Ayman F, Ford, Kristen, Freeman, Gary B, Guimarães, Cristiano R. W, Liu, Shenping, Niosi, Mark, Skoura, Athanasia, Tess, David

Volltext

MAP4K4 Is a Threonine Kinase That Phosphorylates FARP1 von Schwaid, Adam G, Su, Chunyan, Loos, Paula, Wu, Jiang, Nguyen, Chuong, Stone, Kathryn L, Kanyo, Jean, Geoghegan, Kieran F, Bhattacharya, Samit K, Dow, Robert L, Buckbinder, Leonard, Carpino, Philip A

Volltext

Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity von Walker, Daniel P., Zawistoski, Michael P., McGlynn, Molly A., Li, Jian-Cheng, Kung, Daniel W., Bonnette, Peter C., Baumann, Amy, Buckbinder, Leonard, Houser, Janet A., Boer, Jason, Mistry, Anil, Han, Seungil, Guzman-Perez, Li Xing and Angel

Volltext

Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner von Shen, Colette J., Raghavan, Srivatsan, Xu, Zhe, Baranski, Jan D., Yu, Xiang, Wozniak, Michele A., Miller, Jordan S., Gupta, Mudit, Buckbinder, Leonard, Chen, Christopher S.

Volltext

Phosphoproteomic characterization of PYK2 signaling pathways involved in osteogenesis von Bonnette, Peter C., Robinson, Brett S., Silva, Jeffrey C., Stokes, Matthew P., Brosius, Arthur D., Baumann, Amy, Buckbinder, Leonard

Volltext

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2) : Structure-activity relationships and strategies for the elimination of reactive metabolite for... von WALKER, Daniel P, BI, F. Christopher, MCGLYNN, Molly A, OLIVER, Robert, DUNN, Matthew, LI, Jian-Cheng, RICHTER, Daniel T, COOPER, Beth A, KATH, John C, HULFORD, Catherine A, AUTRY, Christopher L, LUZZIO, Michael J, KALGUTKAR, Amit S, UNG, Ethan J, ROBERTS, W. Gregory, BONNETTE, Peter C, BUCKBINDER, Leonard, MISTRY, Anil, GRIFFOR, Matthew C, HAN, Seungil, GUZMAN-PEREZ, Angel, BAUMAN, Jonathan N, ZHAO, Sabrina X, SOGLIA, John R, ASPNES, Gary E, KUNG, Daniel W, KLUG-MCLEOD, Jacquelyn, ZAWISTOSKI, Michael P

Volltext