Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis von Vandeghinste, Nick, Klattig, Jürgen, Jagerschmidt, Catherine, Lavazais, Stéphanie, Marsais, Florence, Haas, Jan D., Auberval, Marielle, Lauffer, Felix, Moran, Tara, Ongenaert, Mate, Van Balen, Maarten, Dupont, Sonia, Lepescheux, Liên, Garcia, Teresa, Härtle, Stefan, Eyerich, Kilian, Fallon, Padraic G., Brys, Reginald, Steidl, Stefan

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Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases von Van Rompaey, Luc, Galien, René, van der Aar, Ellen M, Clement-Lacroix, Philippe, Nelles, Luc, Smets, Bart, Lepescheux, Liên, Christophe, Thierry, Conrath, Katja, Vandeghinste, Nick, Vayssiere, Béatrice, De Vos, Steve, Fletcher, Stephen, Brys, Reginald, van 't Klooster, Gerben, Feyen, Jean H M, Menet, Christel

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Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG... von Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Joncour, Agnès, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Rondet, Emilie, Peixoto, Christophe, Grassot, Jean-Marie, Picolet, Olivier, Annoot, Denis, Triballeau, Nicolas, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Blanque, Roland, Cottereaux, Celine, Vandervoort, Nele, Christophe, Thierry, Mollat, Patrick, Lamers, Marieke, Auberval, Marielle, Hrvacic, Boska, Ralic, Jovica, Oste, Line, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand

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Discovery of 9‑Cyclopropylethynyl-2-((S)‑1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1‑a]­isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing... von Labéguère, Frédéric, Dupont, Sonia, Alvey, Luke, Soulas, Florilène, Newsome, Gregory, Tirera, Amynata, Quenehen, Vanessa, Mai, Thi Thu Trang, Deprez, Pierre, Blanqué, Roland, Oste, Line, Le Tallec, Sandrine, De Vos, Steve, Hagers, Annick, Vandevelde, Ann, Nelles, Luc, Vandervoort, Nele, Conrath, Katja, Christophe, Thierry, van der Aar, Ellen, Wakselman, Emanuelle, Merciris, Didier, Cottereaux, Céline, da Costa, Cécile, Saniere, Laurent, Clement-Lacroix, Philippe, Jenkins, Laura, Milligan, Graeme, Fletcher, Stephen, Brys, Reginald, Gosmini, Romain

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Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors von Joncour, Agnès, Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Peixoto, Christophe, Annoot, Denis, Lepissier, Luce, Heiermann, Jörg, Hengeveld, Willem Jan, Pilzak, Gregor, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Galien, René, David, Christelle, Vandervoort, Nele, Christophe, Thierry, Conrath, Katja, Jans, Mia, Wohlkonig, Alexandre, Soror, Sameh, Steyaert, Jan, Touitou, Robert, Fleury, Damien, Vercheval, Lionel, Mollat, Patrick, Triballeau, Nicolas, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand

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Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic von Pizzonero, Mathieu, Dupont, Sonia, Babel, Marielle, Beaumont, Stéphane, Bienvenu, Natacha, Blanqué, Roland, Cherel, Laëtitia, Christophe, Thierry, Crescenzi, Benedetta, De Lemos, Elsa, Delerive, Philippe, Deprez, Pierre, De Vos, Steve, Djata, Fatoumata, Fletcher, Stephen, Kopiejewski, Sabrina, L’Ebraly, Christelle, Lefrançois, Jean-Michel, Lavazais, Stéphanie, Manioc, Murielle, Nelles, Luc, Oste, Line, Polancec, Denis, Quénéhen, Vanessa, Soulas, Florilène, Triballeau, Nicolas, van der Aar, Ellen M, Vandeghinste, Nick, Wakselman, Emanuelle, Brys, Reginald, Saniere, Laurent

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Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases von Mammoliti, Oscar, Jansen, Koen, El Bkassiny, Sandy, Palisse, Adeline, Triballeau, Nicolas, Bucher, Denis, Allart, Brigitte, Jaunet, Alex, Tricarico, Giovanni, De Wachter, Maxim, Menet, Christel, Blanc, Javier, Letfus, Vatroslav, Rupčić, Renata, Šmehil, Mario, Poljak, Tanja, Coornaert, Beatrice, Sonck, Kathleen, Duys, Inge, Waeckel, Ludovic, Lecru, Lola, Marsais, Florence, Jagerschmidt, Catherine, Auberval, Marielle, Pujuguet, Philippe, Oste, Line, Borgonovi, Monica, Wakselman, Emanuelle, Christophe, Thierry, Houvenaghel, Nicolas, Jans, Mia, Heckmann, Bertrand, Sanière, Laurent, Brys, Reginald

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The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis von Puengel, Tobias, De Vos, Steve, Hundertmark, Jana, Kohlhepp, Marlene, Guldiken, Nurdan, Pujuguet, Philippe, Auberval, Marielle, Marsais, Florence, Shoji, Kenji F., Saniere, Laurent, Trautwein, Christian, Luedde, Tom, Strnad, Pavel, Brys, Reginald, Clement-Lacroix, Philippe, Tacke, Frank

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A multiparameter approach to monitor disease activity in collagen-induced arthritis von Seeuws, Sylvie, Jacques, Peggy, Van Praet, Jens, Drennan, Michael, Coudenys, Julie, Decruy, Tine, Deschepper, Ellen, Lepescheux, Lien, Pujuguet, Philippe, Oste, Line, Vandeghinste, Nick, Brys, Reginald, Verbruggen, Gust, Elewaut, Dirk

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Adenoviral vectors expressing siRNAs for discovery and validation of gene function von Arts, Gert-Jan, Langemeijer, Ellen, Tissingh, Rudi, Ma, Libin, Pavliska, Heidi, Dokic, Kristina, Dooijes, Richele, Mesić, Emir, Clasen, Remko, Michiels, Frits, van der Schueren, Jan, Lambrecht, Mark, Herman, Sofie, Brys, Reginald, Thys, Kim, Hoffmann, Marcel, Tomme, Peter, van Es, Helmuth

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Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases von Mammoliti, Oscar, Martina, Sébastien, Claes, Pieter, Coti, Ghjuvanni, Blanque, Roland, Jagerschmidt, Catherine, Shoji, Kenji, Borgonovi, Monica, De Vos, Steve, Marsais, Florence, Oste, Line, Quinton, Evelyne, López-Ramos, Miriam, Amantini, David, Brys, Reginald, Jimenez, Juan-Miguel, Galien, René, van der Plas, Steven

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Design of a potent and selective dual JAK1/TYK2 inhibitor von Mammoliti, Oscar, Menet, Christel, Cottereaux, Céline, Blanc, Javier, De Blieck, Ann, Coti, Ghjuvanni, Geney, Raphaël, Oste, Line, Ostyn, Koen, Palisse, Adeline, Quinton, Evelyne, Schmitt, Benoit, Borgonovi, Monica, Parent, Isabelle, Jagerschmidt, Catherine, De Vos, Steve, Vayssiere, Béatrice, López-Ramos, Miriam, Shoji, Kenji, Brys, Reginald, Amantini, David, Galien, René, Joannesse, Caroline

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Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634 von Menet, Christel J, Fletcher, Stephen R, Van Lommen, Guy, Geney, Raphael, Blanc, Javier, Smits, Koen, Jouannigot, Nolwenn, Deprez, Pierre, van der Aar, Ellen M, Clement-Lacroix, Philippe, Lepescheux, Liên, Galien, René, Vayssiere, Béatrice, Nelles, Luc, Christophe, Thierry, Brys, Reginald, Uhring, Muriel, Ciesielski, Fabrice, Van Rompaey, Luc

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Sa1844 The JAK1-Selective Inhibitor, Filgotinib, Reverses the Disease Signature of Colon Mucosa in Experimental Colitis von Ongenaert, Mate, Dupont, Sonia, Vayssière, Béatrice, Brys, Reginald, Galien, Rene

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Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Precli... von Mammoliti, Oscar, Palisse, Adeline, Joannesse, Caroline, El Bkassiny, Sandy, Allart, Brigitte, Jaunet, Alex, Menet, Christel, Coornaert, Beatrice, Sonck, Kathleen, Duys, Inge, Clément-Lacroix, Philippe, Oste, Line, Borgonovi, Monica, Wakselman, Emanuelle, Christophe, Thierry, Houvenaghel, Nicolas, Jans, Mia, Heckmann, Bertrand, Sanière, Laurent, Brys, Reginald

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Optimization of Selectivity and Pharmacokinetic Properties of Salt‑Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312 von Temal-Laib, Taouès, Peixoto, Christophe, Desroy, Nicolas, De Lemos, Elsa, Bonnaterre, Florence, Bienvenu, Natacha, Picolet, Olivier, Sartori, Eric, Bucher, Denis, López-Ramos, Miriam, Roca Magadán, Carlos, Laenen, Wendy, Flower, Thomas, Mollat, Patrick, Bugaud, Olivier, Touitou, Robert, Pereira Fernandes, Anna, Lavazais, Stephanie, Monjardet, Alain, Borgonovi, Monica, Gosmini, Romain, Brys, Reginald, Amantini, David, De Vos, Steve, Andrews, Martin

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Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases von Peixoto, Christophe, Joncour, Agnes, Temal-Laib, Taouès, Tirera, Amynata, Dos Santos, Aurélie, Jary, Hélène, Bucher, Denis, Laenen, Wendy, Pereira Fernandes, Anna, Lavazais, Stephanie, Delachaume, Carole, Merciris, Didier, Saccomani, Corinne, Drennan, Michael, López-Ramos, Miriam, Wakselman, Emanuelle, Dupont, Sonia, Borgonovi, Monica, Roca Magadan, Carlos, Monjardet, Alain, Brys, Reginald, De Vos, Steve, Andrews, Martin, Jimenez, Juan-Miguel, Amantini, David, Desroy, Nicolas

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Correction to Discovery, Structure–Activity Relationship, and Binding Mode of an Imidazo[1,2‑a]pyridine Series of Autotaxin Inhibitors von Joncour, Agnès, Desroy, Nicolas, Housseman, Christopher, Bock, Xavier, Bienvenu, Natacha, Cherel, Laëtitia, Labeguere, Virginie, Peixoto, Christophe, Annoot, Denis, Lepissier, Luce, Heiermann, Jörg, Hengeveld, Willem Jan, Pilzak, Gregor, Monjardet, Alain, Wakselman, Emanuelle, Roncoroni, Veronique, Le Tallec, Sandrine, Galien, René, David, Christelle, Vandervoort, Nele, Christophe, Thierry, Conrath, Katja, Jans, Mia, Wohlkonig, Alexandre, Soror, Sameh, Steyaert, Jan, Touitou, Robert, Fleury, Damien, Vercheval, Lionel, Mollat, Patrick, Triballeau, Nicolas, van der Aar, Ellen, Brys, Reginald, Heckmann, Bertrand

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Abstract 1753: GLPG1790: The first Ephrin (EPH) receptor tyrosine kinase inhibitor for the treatment of triple negative breast cancer von Pujuguet, Philippe, Beirinckx, Filip, Delachaume, Carole, Huck, Jacques, Aar, Ellen Van der, Brys, Reginald, Rompaey, Luc Van, Wigerinck, Piet, Saniere, Laurent

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188 Exploration of GLPG0634, the First Selective JAK1 Inhibitor, in Inflammatory Bowel Disease Is Supported by Early Clinical Results and Mouse DSS-Colitis Data von Galien, Rene, Merciris, Didier, Vanhoutte, Frédéric P, Delachaume, Carole, Namour, Florence S, Vayssière, Béatrice, Van der Aa, Annegret, Brys, Reginald, van't Klooster, Gerben A

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