Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467 von Brady, Patrick B., Sorensen, Bryan K., Risi, Roberto M., Curtin, Michael L., Mantei, Robert A., Florjancic, Alan S., Mastracchio, Anthony, Ji, Cheng, Kunzer, Aaron R., Lai, Chunqiu, Storer, Gregory E., Chan, Vincent S., Henry, Rodger F., Souers, Andrew J., Michaelides, Michael R., Judd, Andrew S., Hansen, T. Matthew

Volltext

SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) von Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.

Volltext

Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases von Fidanze, Steve D., Erickson, Scott A., Wang, Gary T., Mantei, Robert, Clark, Richard F., Sorensen, Bryan K., Bamaung, Nwe Y., Kovar, Peter, Johnson, Eric F., Swinger, Kerren K., Stewart, Kent D., Zhang, Qian, Tucker, Lora A., Pappano, William N., Wilsbacher, Julie L., Wang, Jieyi, Sheppard, George S., Bell, Randy L., Davidsen, Steven K., Hubbard, Robert D.

Volltext

Discovery and Metabolic Stabilization of Potent and Selective 2-Amino-N-(adamant-2-yl) Acetamide 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors von Rohde, Jeffrey J, Pliushchev, Marina A, Sorensen, Bryan K, Wodka, Dariusz, Shuai, Qi, Wang, Jiahong, Fung, Steven, Monzon, Katina M, Chiou, William J, Pan, Liping, Deng, Xiaoqing, Chovan, Linda E, Ramaiya, Atul, Mullally, Mark, Henry, Rodger F, Stolarik, DeAnne F, Imade, Hovis M, Marsh, Kennan C, Beno, David W. A, Fey, Thomas A, Droz, Brian A, Brune, Michael E, Camp, Heidi S, Sham, Hing L, Frevert, Ernst Uli, Jacobson, Peer B, Link, J. T

Volltext

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ETB Selectivity von von Geldern, Thomas W, Tasker, Andrew S, Sorensen, Bryan K, Winn, Martin, Szczepankiewicz, Bruce G, Dixon, Douglas B, Chiou, William J, Wang, Liming, Wessale, Jerry L, Adler, Andy, Marsh, Kennan C, Nguyen, Bach, Opgenorth, Terry J

Volltext

Stereoselective Synthesis of ABBV-992 Enabled by a Flow Diazotization and a Partial Reduction of a Pyridone von Brady, Patrick B., Harper, Kaid C., Sorensen, Bryan K., Greszler, Stephen N., Lai, Chunqiu, Florjancic, Alan S., Zhao, Gang, Shelat, Bhadra H., Storer, Gregory E., Henry, Rodger F., Hansen, T. Matthew

Volltext

Biaryl amide glucagon receptor antagonists von KURUKULASURIYA, Ravi, SORENSEN, Bryan K, ADLER, Andrew L, COLLINS, Christine A, LINK, James T, PATEL, Jyoti R, JAE, Hwan-Soo, WINN, Marty X, ROHDE, Jeffrey R, GRIHALDE, Nelson D, LIN, Chun W, OGIELA, Christopher A

Volltext

Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 5. Highly Selective, Potent, and Orally Active ETA Antagonists von Jae, Hwan-Soo, Winn, Martin, von Geldern, Thomas W, Sorensen, Bryan K, Chiou, William J, Nguyen, Bach, Marsh, Kennan C, Opgenorth, Terry J

Volltext

Discovery of novel nonsteroidal glucocorticoid receptor modulators von LINK, J. T, SORENSEN, Bryan K, PATEL, Jyoti, EMERY, Maurice, GRYNFARB, Marlena, GOOS-NILSSON, Annika

Volltext

Synthesis, activity, metabolic stability, and pharmacokinetics of glucocorticoid receptor modulator–statin hybrids von Link, J.T, Sorensen, Bryan K, Lai, Chunqiu, Wang, Jiahong, Fung, Steven, Deng, Daisy, Emery, Maurice, Carroll, Sherry, Grynfarb, Marlena, Goos-Nilsson, Annika, von Geldern, Thomas

Volltext

2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ETA Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722 von Winn, Martin, von Geldern, Thomas W, Opgenorth, Terry J, Jae, Hwan-Soo, Tasker, Andrew S, Boyd, Steven A, Kester, Jeffrey A, Mantei, Robert A, Bal, Radhika, Sorensen, Bryan K, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Novosad, Eugene I, Hernandez, Lisa, Marsh, Kennan C

Volltext

Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators von Link, J.T, Sorensen, Bryan K, Patel, Jyoti, Arendsen, David, Li, Gaoquan, Swanson, Susan, Nguyen, Bach, Emery, Maurice, Grynfarb, Marlena, Goos-Nilsson, Annika

Volltext

Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator von Tu, Noah, Link, J.T, Sorensen, Bryan K, Emery, Maurice, Grynfarb, Marlena, Goos-Nilsson, Annika, Nguyen, Bach

Volltext

An Evaluation of a C-Glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist von Sorensen, Bryan K., Link, J.T., von Geldern, Thomas, Emery, Maurice, Wang, Jiahong, Hickman, Bach, Grynfarb, Marlena, Goos-Nilsson, Annika, Carroll, Sherry

Volltext

Potent and Selective Non-Benzodioxole-Containing Endothelin-A Receptor Antagonists von Tasker, Andrew S, Sorensen, Bryan K, Jae, Hwan-Soo, Winn, Martin, von Geldern, Thomas W, Dixon, Douglas B, Chiou, William J, Dayton, Brian D, Calzadila, Samuel, Hernandez, Lisa, Marsh, Kennan C, WuWong, J. Ruth, Opgenorth, Terry J

Volltext

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET A receptor selectivity von Boyd, Steven A, Mantei, Robert A, Tasker, Andrew S, Liu, Gang, Sorensen, Bryan K, Henry Jr, Kenneth J, von Geldern, Thomas W, Winn, Martin, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Hutchins, Charles W, Marsh, Kennan C, Nguyen, Bach, Opgenorth, Terry J

Volltext

Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors von Sorensen, Bryan, Winn, Martin, Rohde, Jeff, Shuai, Qi, Wang, Jiahong, Fung, Steven, Monzon, Katina, Chiou, William, Stolarik, DeAnne, Imade, Hovis, Pan, Liping, Deng, Xiaoqing, Chovan, Linda, Longenecker, Kenton, Judge, Russell, Qin, Wenying, Brune, Michael, Camp, Heidi, Frevert, Ernst U., Jacobson, Peer, Link, J.T.

Volltext

A method for preparing C-glycosides related to phlorizin von Link, J.T, Sorensen, Bryan K

Volltext

Adamantane 11-β-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction von Sorensen, Bryan, Rohde, Jeff, Wang, Jiahong, Fung, Steven, Monzon, Katina, Chiou, William, Pan, Liping, Deng, Xiaoqing, Stolarik, DeAnne, Frevert, Ernst U., Jacobson, Peer, Link, J.T.

Volltext

Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors von Wilsbacher, Julie L, Cheng, Min, Cheng, Dong, Trammell, Samuel A J, Shi, Yan, Guo, Jun, Koeniger, Stormy L, Kovar, Peter J, He, Yupeng, Selvaraju, Sujatha, Heyman, H Robin, Sorensen, Bryan K, Clark, Richard F, Hansen, T Matthew, Longenecker, Kenton L, Raich, Diana, Korepanova, Alla V, Cepa, Steven, Towne, Danli L, Abraham, Vivek C, Tang, Hua, Richardson, Paul L, McLoughlin, Shaun M, Badagnani, Ilaria, Curtin, Michael L, Michaelides, Michael R, Maag, David, Buchanan, F Gregory, Chiang, Gary G, Gao, Wenqing, Rosenberg, Saul H, Brenner, Charles, Tse, Chris

Volltext