Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids von Pérez, María José, Ivanyuk, Dina, Panagiotakopoulou, Vasiliki, Di Napoli, Gabriele, Kalb, Stefanie, Brunetti, Dario, Al-Shaana, Rawaa, Kaeser, Stephan A., Fraschka, Sabine Anne-Kristin, Jucker, Mathias, Zeviani, Massimo, Viscomi, Carlo, Deleidi, Michela

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Advances in Mitochondria-Targeted Drug Delivery von Bottani, Emanuela, Brunetti, Dario

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Fetal and obstetrics manifestations of mitochondrial diseases von Adelizzi, Alessia, Giri, Anastasia, Di Donfrancesco, Alessia, Boito, Simona, Prigione, Alessandro, Bottani, Emanuela, Bollati, Valentina, Tiranti, Valeria, Persico, Nicola, Brunetti, Dario

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Therapeutic Approaches to Treat Mitochondrial Diseases: “One-Size-Fits-All” and “Precision Medicine” Strategies von Bottani, Emanuela, Lamperti, Costanza, Prigione, Alessandro, Tiranti, Valeria, Persico, Nicola, Brunetti, Dario

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Editorial: Mitochondrial therapy in neurodegeneration von Kalani, Anuradha, Chaturvedi, Pankaj, Brunetti, Dario, Kalani, Komal

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Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome von Inak, Gizem, Rybak-Wolf, Agnieszka, Lisowski, Pawel, Pentimalli, Tancredi M., Jüttner, René, Glažar, Petar, Uppal, Karan, Bottani, Emanuela, Brunetti, Dario, Secker, Christopher, Zink, Annika, Meierhofer, David, Henke, Marie-Thérèse, Dey, Monishita, Ciptasari, Ummi, Mlody, Barbara, Hahn, Tobias, Berruezo-Llacuna, Maria, Karaiskos, Nikos, Di Virgilio, Michela, Mayr, Johannes A., Wortmann, Saskia B., Priller, Josef, Gotthardt, Michael, Jones, Dean P., Mayatepek, Ertan, Stenzel, Werner, Diecke, Sebastian, Kühn, Ralf, Wanker, Erich E., Rajewsky, Nikolaus, Schuelke, Markus, Prigione, Alessandro

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Exploring the Relevance of Senotherapeutics for the Current SARS-CoV-2 Emergency and Similar Future Global Health Threats von Malavolta, Marco, Giacconi, Robertina, Brunetti, Dario, Provinciali, Mauro, Maggi, Fabrizio

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Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes von Giuliani, Maria Elisa, Bigossi, Giorgia, Lai, Giovanni, Marcozzi, Serena, Brunetti, Dario, Malavolta, Marco

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Gene Therapy for Mitochondrial Diseases: Current Status and Future Perspective von Di Donfrancesco, Alessia, Massaro, Giulia, Di Meo, Ivano, Tiranti, Valeria, Bottani, Emanuela, Brunetti, Dario

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Correction to: Fetal and obstetrics manifestations of mitochondrial diseases von Adelizzi, Alessia, Giri, Anastasia, Di Donfrancesco, Alessia, Boito, Simona, Prigione, Alessandro, Bottani, Emanuela, Bollati, Valentina, Tiranti, Valeria, Persico, Nicola, Brunetti, Dario

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Targeting Multiple Mitochondrial Processes by a Metabolic Modulator Prevents Sarcopenia and Cognitive Decline in SAMP8 Mice von Brunetti, Dario, Bottani, Emanuela, Segala, Agnese, Marchet, Silvia, Rossi, Fabio, Orlando, Fiorenza, Malavolta, Marco, Carruba, Michele O., Lamperti, Costanza, Provinciali, Mauro, Nisoli, Enzo, Valerio, Alessandra

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Generation of two human iPSC lines, HMGUi004-A and FINCBi004-A, from fibroblasts of MPAN patients carrying pathogenic recessive mutations in the gene C19orf12 von Zanuttigh, Enrica, Rusha, Ejona, Peron, Camille, Brunetti, Dario, Zorzi, Giovanna, Pertek, Anna, Nteli, Polyxeni, Winkelmann, Juliane, Tiranti, Valeria, Iuso, Arcangela

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Role of PITRM1 in Mitochondrial Dysfunction and Neurodegeneration von Brunetti, Dario, Catania, Alessia, Viscomi, Carlo, Deleidi, Michela, Bindoff, Laurence A., Ghezzi, Daniele, Zeviani, Massimo

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Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration von Brunetti, Dario, Torsvik, Janniche, Dallabona, Cristina, Teixeira, Pedro, Sztromwasser, Pawel, Fernandez‐Vizarra, Erika, Cerutti, Raffaele, Reyes, Aurelio, Preziuso, Carmela, D'Amati, Giulia, Baruffini, Enrico, Goffrini, Paola, Viscomi, Carlo, Ferrero, Ileana, Boman, Helge, Telstad, Wenche, Johansson, Stefan, Glaser, Elzbieta, Knappskog, Per M, Zeviani, Massimo, Bindoff, Laurence A

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PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1 -deficient patients von Di Donfrancesco, Alessia, Berlingieri, Christian, Giacomello, Marta, Frascarelli, Chiara, Magalhaes Rebelo, Ana Paula, Bindoff, Laurence A, Reeval, Segel, Renbaum, Paul, Santorelli, Filippo M, Massaro, Giulia, Viscomi, Carlo, Zeviani, Massimo, Ghezzi, Daniele, Bottani, Emanuela, Brunetti, Dario

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Cellular senescence and frailty: a comprehensive insight into the causal links von Marcozzi, Serena, Bigossi, Giorgia, Giuliani, Maria Elisa, Giacconi, Robertina, Piacenza, Francesco, Cardelli, Maurizio, Brunetti, Dario, Segala, Agnese, Valerio, Alessandra, Nisoli, Enzo, Lattanzio, Fabrizia, Provinciali, Mauro, Malavolta, Marco

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Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice von Marcozzi, Serena, Bigossi, Giorgia, Giuliani, Maria Elisa, Giacconi, Robertina, Cardelli, Maurizio, Piacenza, Francesco, Orlando, Fiorenza, Segala, Agnese, Valerio, Alessandra, Nisoli, Enzo, Brunetti, Dario, Puca, Annibale, Boschi, Federico, Gaetano, Carlo, Mongelli, Alessia, Lattanzio, Fabrizia, Provinciali, Mauro, Malavolta, Marco

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Mitochondria in neurogenesis: Implications for mitochondrial diseases von Brunetti, Dario, Dykstra, Werner, Le, Stephanie, Zink, Annika, Prigione, Alessandro

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Development, embryonic genome activity and mitochondrial characteristics of bovine–pig inter-family nuclear transfer embryos von Lagutina, Irina, Fulka, Helena, Brevini, Tiziana A L, Antonini, Stefania, Brunetti, Dario, Colleoni, Silvia, Gandolfi, Fulvio, Lazzari, Giovanna, Fulka, Josef, Galli, Cesare

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Direct Derivation of Neural Rosettes from Cloned Bovine Blastocysts: A Model of Early Neurulation Events and Neural Crest Specification In Vitro von Lazzari, Giovanna, Colleoni, Silvia, Giannelli, Serena G., Brunetti, Dario, Colombo, Elena, Lagutina, Irina, Galli, Cesare, Broccoli, Vania

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