Strategies to Obtain Diverse and Specific Human Monoclonal Antibodies From Transgenic Animals von Brüggemann, Marianne, Osborn, Michael J, Ma, Biao, Buelow, Roland

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Human antibody expression in transgenic rats: Comparison of chimeric IgH loci with human VH, D and JH but bearing different rat C-gene regions von Ma, Biao, Osborn, Michael J., Avis, Suzanne, Ouisse, Laure-Hélène, Ménoret, Séverine, Anegon, Ignacio, Buelow, Roland, Brüggemann, Marianne

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Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies von Clarke, Starlynn C, Ma, Biao, Trinklein, Nathan D, Schellenberger, Ute, Osborn, Michael J, Ouisse, Laure-Hélène, Boudreau, Andrew, Davison, Laura M, Harris, Katherine E, Ugamraj, Harshad S, Balasubramani, Aarti, Dang, Kevin H, Jorgensen, Brett, Ogana, Heather Anne N, Pham, Duy T, Pratap, Payal P, Sankaran, Preethi, Anegon, Ignacio, van Schooten, Wim C, Brüggemann, Marianne, Buelow, Roland, Force Aldred, Shelley

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The two-domain hypothesis in Beckwith–Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster von Cerrato, Flavia, Sparago, Angela, Matteo, Ines Di, Zou, Xiangang, Dean, Wendy, Sasaki, Hiroyuki, Smith, Paul, Genesio, Rita, Bruggemann, Marianne, Reik, Wolf, Riccio, Andrea

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Characterization of immunoglobulin heavy chain knockout rats von Ménoret, Séverine, Iscache, Anne-L, Tesson, Laurent, Rémy, Séverine, Usal, Claire, Osborn, Michel J, Cost, Gregory J, Brüggemann, Marianne, Buelow, Roland, Anegon, Ignacio

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Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies von Harris, Katherine E, Aldred, Shelley Force, Davison, Laura M, Ogana, Heather Anne N, Boudreau, Andrew, Brüggemann, Marianne, Osborn, Michael, Ma, Biao, Buelow, Benjamin, Clarke, Starlynn C, Dang, Kevin H, Iyer, Suhasini, Jorgensen, Brett, Pham, Duy T, Pratap, Payal P, Rangaswamy, Udaya S, Schellenberger, Ute, van Schooten, Wim C, Ugamraj, Harshad S, Vafa, Omid, Buelow, Roland, Trinklein, Nathan D

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Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminativ... von Ouisse, Laure-Hélène, Gautreau-Rolland, Laetitia, Devilder, Marie-Claire, Osborn, Michael, Moyon, Melinda, Visentin, Jonathan, Halary, Frank, Bruggemann, Marianne, Buelow, Roland, Anegon, Ignacio, Saulquin, Xavier

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Expression of a Dromedary Heavy Chain-Only Antibody and B Cell Development in the Mouse von Zou, Xiangang, Smith, Jennifer A, Nguyen, Viet Khong, Ren, Liming, Luyten, Kattie, Muyldermans, Serge, Bruggemann, Marianne

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Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice von Zou, Xiangang, Osborn, Michael J, Bolland, Daniel J, Smith, Jennifer A, Corcos, Daniel, Hamon, Maureen, Oxley, David, Hutchings, Amanda, Morgan, Geoff, Santos, Fatima, Kilshaw, Peter J, Taussig, Michael J, Corcoran, Anne E, Brüggemann, Marianne

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Abstract LB-090: Sequence-based discovery of fully human anti-CD3 and anti-PDL1 single domain antibodies using novel transgenic rats von Trinklein, Nathan, Force Aldred, Shelley, Schellenberger, Ute, Harris, Kat, Clarke, Starlynn, Dang, Kevin, Pham, Duy, Bruggemann, Marianne, vanSchooten, Wim

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Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain von Corcos, Daniel, Osborn, Michael J., Matheson, Louise S., Santos, Fatima, Zou, Xiangang, Smith, Jennifer A., Morgan, Geoff, Hutchings, Amanda, Hamon, Maureen, Oxley, David, Brüggemann, Marianne

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Human Antibody Production in Transgenic Animals von Brüggemann, Marianne, Osborn, Michael J., Ma, Biao, Hayre, Jasvinder, Avis, Suzanne, Lundstrom, Brian, Buelow, Roland

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Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain von Zou, Xiangang, Piper, Tony A, Smith, Jennifer A, Allen, Nicholas D, Xian, Jian, Brüggemann, Marianne

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Selection of a human anti-progesterone antibody fragment from a transgenic mouse library by ARM ribosome display von He, Mingyue, Menges, Margit, Groves, Maria A.T, Corps, Elaine, Liu, Hong, Brüggemann, Marianne, Taussig, Michael J

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High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region von Osborn, Michael J, Ma, Biao, Avis, Suzanne, Binnie, Ashleigh, Dilley, Jeanette, Yang, Xi, Lindquist, Kevin, Ménoret, Séverine, Iscache, Anne-Laure, Ouisse, Laure-Hélène, Rajpal, Arvind, Anegon, Ignacio, Neuberger, Michael S, Buelow, Roland, Brüggemann, Marianne

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A second B cell-specific enhancer 3' of the immunoglobulin heavy-chain locus von Pettersson, Sven, Cook, Graham P, Brüggemann, Marianne, Williams, Gareth T, Neuberger, Michael S

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POLYNUCLEOTIDES ENCODING RODENT ANTIBODIES WITH HUMAN IDIOTYPES AND ANIMALS COMPRISING SAME von MA, Biao, OSBORN, Michael, BRUGGEMANN, Marianne, BUELOW, Roland

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B-cell tumorigenesis in mice carrying a yeast artificial chromosome-based immunoglobulin heavy/c-myc translocus is independent of the heavy chain intron enhancer (Eμ) von PALOMO, C, XIANGANG ZOU, NICHOLSON, I. C, BÜTZLER, C, BRÜGGEMANN, M

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HUMAN ANTIBODIES FROM TRANSGENIC RODENTS WITH MULTIPLE HEAVY CHAIN IMMUNOGLOBULIN LOCI von MA, Biao, BRUGGEMANN, Marianne, BUELOW, Roland, OSBORN, Michael J

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POLYNUKLEOTIDER, DER KODER FOR GNAVERANTISTOFFER MED HUMANE IDIOTYPER, OG DYR, DER OMFATTER DISSE von MA, Biao, BRUGGEMANN, Marianne, OSBORN, Michael, J, BUELOW, Roland

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