Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain von Maphis, Nicole, Xu, Guixiang, Kokiko-Cochran, Olga N, Jiang, Shanya, Cardona, Astrid, Ransohoff, Richard M, Lamb, Bruce T, Bhaskar, Kiran

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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease von Jay, Taylor R, Hirsch, Anna M, Broihier, Margaret L, Miller, Crystal M, Neilson, Lee E, Ransohoff, Richard M, Lamb, Bruce T, Landreth, Gary E

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Inflammation as a central mechanism in Alzheimer's disease von Kinney, Jefferson W., Bemiller, Shane M., Murtishaw, Andrew S., Leisgang, Amanda M., Salazar, Arnold M., Lamb, Bruce T.

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Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling von Gunner, Georgia, Cheadle, Lucas, Johnson, Kasey M., Ayata, Pinar, Badimon, Ana, Mondo, Erica, Nagy, M. Aurel, Liu, Liwang, Bemiller, Shane M., Kim, Ki-Wook, Lira, Sergio A., Lamb, Bruce T., Tapper, Andrew R., Ransohoff, Richard M., Greenberg, Michael E., Schaefer, Anne, Schafer, Dorothy P.

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models von Jay, Taylor R, Miller, Crystal M, Cheng, Paul J, Graham, Leah C, Bemiller, Shane, Broihier, Margaret L, Xu, Guixiang, Margevicius, Daniel, Karlo, J Colleen, Sousa, Gregory L, Cotleur, Anne C, Butovsky, Oleg, Bekris, Lynn, Staugaitis, Susan M, Leverenz, James B, Pimplikar, Sanjay W, Landreth, Gary E, Howell, Gareth R, Ransohoff, Richard M, Lamb, Bruce T

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INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia von Tsai, Andy P., Lin, Peter Bor-Chian, Dong, Chuanpeng, Moutinho, Miguel, Casali, Brad T., Liu, Yunlong, Lamb, Bruce T., Landreth, Gary E., Oblak, Adrian L., Nho, Kwangsik

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Regulation of Tau Pathology by the Microglial Fractalkine Receptor von Bhaskar, Kiran, Konerth, Megan, Kokiko-Cochran, Olga N., Cardona, Astrid, Ransohoff, Richard M., Lamb, Bruce T.

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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease von Jay, Taylor R, Hirsch, Anna M, Broihier, Margaret L, Miller, Crystal M, Neilson, Lee E, Ransohoff, Richard M, Lamb, Bruce T, Landreth, Gary E

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CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models von Lee, Sungho, Varvel, Nicholas H, Konerth, Megan E, Xu, Guixiang, Cardona, Astrid E, Ransohoff, Richard M, Lamb, Bruce T

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TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment von Jay, Taylor R., Saucken, Victoria E., Muñoz, Braulio, Codocedo, Juan F., Atwood, Brady K., Lamb, Bruce T., Landreth, Gary E.

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Vascular contributions to cognitive impairment and dementia including Alzheimer's disease von Snyder, Heather M, Corriveau, Roderick A, Craft, Suzanne, Faber, James E, Greenberg, Steven M, Knopman, David, Lamb, Bruce T, Montine, Thomas J, Nedergaard, Maiken, Schaffer, Chris B, Schneider, Julie A, Wellington, Cheryl, Wilcock, Donna M, Zipfel, Gregory J, Zlokovic, Berislav, Bain, Lisa J, Bosetti, Francesca, Galis, Zorina S, Koroshetz, Walter, Carrillo, Maria C

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Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events von Bhaskar, Kiran, Maphis, Nicole, Xu, Guixiang, Varvel, Nicholas H, Kokiko-Cochran, Olga N, Weick, Jason P, Staugaitis, Susan M, Cardona, Astrid, Ransohoff, Richard M, Herrup, Karl, Lamb, Bruce T

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Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease von Savage, Julie C, Jay, Taylor, Goduni, Elanda, Quigley, Caitlin, Mariani, Monica M, Malm, Tarja, Ransohoff, Richard M, Lamb, Bruce T, Landreth, Gary E

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TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy von Bemiller, Shane M, McCray, Tyler J, Allan, Kevin, Formica, Shane V, Xu, Guixiang, Wilson, Gina, Kokiko-Cochran, Olga N, Crish, Samuel D, Lasagna-Reeves, Cristian A, Ransohoff, Richard M, Landreth, Gary E, Lamb, Bruce T

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Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study von Oblak, Adrian L, Lin, Peter B, Kotredes, Kevin P, Pandey, Ravi S, Garceau, Dylan, Williams, Harriet M, Uyar, Asli, O'Rourke, Rita, O'Rourke, Sarah, Ingraham, Cynthia, Bednarczyk, Daria, Belanger, Melisa, Cope, Zackary A, Little, Gabriela J, Williams, Sean-Paul G, Ash, Carl, Bleckert, Adam, Ragan, Tim, Logsdon, Benjamin A, Mangravite, Lara M, Sukoff Rizzo, Stacey J, Territo, Paul R, Carter, Gregory W, Howell, Gareth R, Sasner, Michael, Lamb, Bruce T

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Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury von Saber, Maha, Kokiko-Cochran, Olga, Puntambekar, Shweta S, Lathia, Justin D, Lamb, Bruce T

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The importance of continuing development of novel animal models of Alzheimer's disease and Alzheimer's disease and related dementias von Wilcock, Donna M., Lamb, Bruce T.

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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain von Ghosal, Kaushik, Vogt, Daniel L, Liang, Man, Shen, Yong, Lamb, Bruce T, Pimplikar, Sanjay W

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Transgenic amyloid precursor protein mouse models of amyloidosis. Incomplete models for Alzheimer's disease but effective predictors of anti‐amyloid therapies von Morgan, David G., Lamb, Bruce T.

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The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease von Cheng-Hathaway, Paul J, Reed-Geaghan, Erin G, Jay, Taylor R, Casali, Brad T, Bemiller, Shane M, Puntambekar, Shweta S, von Saucken, Victoria E, Williams, Roxanne Y, Karlo, J Colleen, Moutinho, Miguel, Xu, Guixiang, Ransohoff, Richard M, Lamb, Bruce T, Landreth, Gary E

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