Design, Synthesis, and Structure−Activity Relationships of Novel 2-Substituted Pyrazinoylguanidine Epithelial Sodium Channel Blockers:  Drugs for Cystic Fibrosis and Chronic Bronch... von Hirsh, Andrew J, Molino, Bruce F, Zhang, Jianzhong, Astakhova, Nadezhda, Geiss, William B, Sargent, Bruce J, Swenson, Brian D, Usyatinsky, Alexander, Wyle, Michael J, Boucher, Richard C, Smith, Rick T, Zamurs, Andra, Johnson, M. Ross

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CSTI-300 (SMP-100); a Novel 5-HT3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome von Roberts, Alexander, Grafton, Gillian, Powell, Andrew D., Brock, Kristian, Chen, Chunlin, Xie, Dejian, Huang, Jinkun, Liu, Shuang, Cooper, Alison J., Brady, Catherine A., Qureshi, Omar, Stamataki, Zania, Manning, David D., Moore, Nicholas A., Sargent, Bruce J., Guzzo, Peter R., Barnes, Nicholas M.

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New central targets for the treatment of obesity von Sargent, Bruce J., Moore, Nicholas A.

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From preclinical to clinical development: The example of a novel treatment for obesity von Moore, Nicholas A, Sargent, Bruce J, Guzzo, Peter R, Surman, Matthew D

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Targeting 5-HT receptors for the treatment of obesity von Sargent, Bruce J, Henderson, Alan J

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CSTI-300 (SMP-100); a Novel 5-HT 3 Receptor Partial Agonist with Potential to Treat Patients with Irritable Bowel Syndrome or Carcinoid Syndrome von Roberts, Alexander, Grafton, Gillian, Powell, Andrew D, Brock, Kristian, Chen, Chunlin, Xie, Dejian, Huang, Jinkun, Liu, Shuang, Cooper, Alison J, Brady, Catherine A, Qureshi, Omar, Stamataki, Zania, Manning, David D, Moore, Nicholas A, Sargent, Bruce J, Guzzo, Peter R, Barnes, Nicholas M

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Synthesis and Biological Evaluation of N‑((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter‑1 von Cioffi, Christopher L, Liu, Shuang, Wolf, Mark A, Guzzo, Peter R, Sadalapure, Kashinath, Parthasarathy, Visweswaran, Loong, David T. J, Maeng, Jun-Ho, Carulli, Edmund, Fang, Xiao, Karunakaran, Kalesh, Matta, Lakshman, Choo, Sok Hui, Panduga, Shailijia, Buckle, Ronald N, Davis, Randall N, Sakwa, Samuel A, Gupta, Priya, Sargent, Bruce J, Moore, Nicholas A, Luche, Michele M, Carr, Grant J, Khmelnitsky, Yuri L, Ismail, Jiffry, Chung, Mark, Bai, Mei, Leong, Wei Yee, Sachdev, Nidhi, Swaminathan, Srividya, Mhyre, Andrew J

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Partial Agonism of 5‑HT3 Receptors: A Novel Approach to the Symptomatic Treatment of IBS‑D von Moore, Nicholas A, Sargent, Bruce J, Manning, David D, Guzzo, Peter R

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Design and Synthesis of 4‑Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors von Liu, Shuang, Zha, Congxiang, Nacro, Kassoum, Hu, Min, Cui, Wenge, Yang, Yuh-Lin, Bhatt, Ulhas, Sambandam, Aruna, Isherwood, Matthew, Yet, Larry, Herr, Michael T, Ebeltoft, Sarah, Hassler, Carla, Fleming, Linda, Pechulis, Anthony D, Payen-Fornicola, Anne, Holman, Nicholas, Milanowski, Dennis, Cotterill, Ian, Mozhaev, Vadim, Khmelnitsky, Yuri, Guzzo, Peter R, Sargent, Bruce J, Molino, Bruce F, Olson, Richard, King, Dalton, Lelas, Snjezana, Li, Yu-Wen, Johnson, Kim, Molski, Thaddeus, Orie, Anitra, Ng, Alicia, Haskell, Roy, Clarke, Wendy, Bertekap, Robert, O’Connell, Jonathan, Lodge, Nicholas, Sinz, Michael, Adams, Stephen, Zaczek, Robert, Macor, John E

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Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity von Liu, Jian, He, Shuwen, Jian, Tianying, Dobbelaar, Peter H., Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J, Swenson, Brian, Yet, Larry, Tamvakopoulos, Constantin, Peng, Qianping, Pan, Jie, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Howard, Andrew D., Marsh, Donald J., Metzger, Joseph M., Reitman, Marc L., Wyvratt, Matthew J., Nargund, Ravi P.

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Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity von Hadden, Mark, Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Henderson, Alan J., Pattamana, Kevin, Ruenz, Megan, Sargent, Bruce J., Swenson, Brian, Yet, Larry, Liu, Jian, He, Shuwen, Sebhat, Iyassu K., Lin, Linus S., Tamvakopoulos, Constantin, Peng, Qianping, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiao-Ming, Metzger, Joseph M., Reitman, Marc L., Nargund, Ravi P.

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Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists von He, Shuwen, Dobbelaar, Peter H., Liu, Jian, Jian, Tianying, Sebhat, Iyassu K., Lin, Linus S., Goodman, Allan, Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Henderson, Alan J., Ruenz, Megan, Sargent, Bruce J., Yet, Larry, Kelly, Theresa M., Palyha, Oksana, Kan, Yanqing, Pan, Jie, Chen, Howard, Marsh, Donald J., Shearman, Lauren P., Strack, Alison M., Metzger, Joseph M., Feighner, Scott D., Tan, Carina, Howard, Andrew D., Tamvakopoulos, Constantin, Peng, Qianping, Guan, Xiao-Ming, Reitman, Marc L., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.

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Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]-[2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists von CHENG GUO, GUZZO, Peter R, GAGEN, Karen, METZGER, Joseph M, DRAGOVIC, Jasminka, LYONS, Kathryn, LIN, Linus S, NARGUND, Ravi P, HADDEN, Mark, SARGENT, Bruce J, YET, Larry, YANQING KAN, PALYHA, Oksana, KELLY, Theresa M, XIAOMING GUAN, ROSKO, Kim

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New central targets for the treatment of obesity : Obesity von SARGENT, Bruce J, MOORE, Nicholas A

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Oxidative decarbonylation of β-arylpyruvic acids using sodium perborate von Morrow, Nicholas, Ramsden, Christopher A, Sargent, Bruce J, Wallett, Christiaan D

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Partial Agonism of 5-HT 3 Receptors: A Novel Approach to the Symptomatic Treatment of IBS-D von Moore, Nicholas A., Sargent, Bruce J., Manning, David D., Guzzo, Peter R.

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Synthesis of 7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3 H-pyrazolo[3,4- c][2,7]naphthyridin-1-ylamine and its analogs as bombesin receptor subtype-3 agonists von Guo, Cheng, Guzzo, Peter R., Hadden, Mark, Sargent, Bruce J., Yet, Larry, Kan, Yanqing, Palyha, Oksana, Kelly, Theresa M., Guan, Xiaoming, Rosko, Kim, Gagen, Karen, Metzger, Joseph M., Dragovic, Jasminka, Lyons, Kathryn, Lin, Linus S., Nargund, Ravi P.

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A novel decarbonylation of heterocyclic pyruvic acid derivatives using sodium perborate von Ramsden, Christopher A., Sargent, Bruce J., Wallett, Christiaan D.

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CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS von SARGENT, BRUCE, J, MOLINO, BRUCE, F, ZHANG, JIANZHONG, JOHNSON, MICHAEL, R

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CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS von SARGENT, BRUCE J, ZHANG, JIANZHONG, MOLINO, BRUCE F, JOHNSON, MICHAEL R

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