Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo von DiTommaso, Tia, Cole, Julie M., Cassereau, Luke, Buggé, Joshua A., Hanson, Jacquelyn L. Sikora, Bridgen, Devin T., Stokes, Brittany D., Loughhead, Scott M., Beutel, Bruce A., Gilbert, Jonathan B., Nussbaum, Kathrin, Sorrentino, Antonio, Toggweiler, Janine, Schmidt, Tobias, Gyuelveszi, Gabor, Bernstein, Howard, Sharei, Armon

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SOS-NMR:  A Saturation Transfer NMR-Based Method for Determining the Structures of Protein−Ligand Complexes von Hajduk, Philip J, Mack, Jamey C, Olejniczak, Edward T, Park, Chang, Dandliker, Peter J, Beutel, Bruce A

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Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors von Gu, Yu Gui, Weitzberg, Moshe, Clark, Richard F, Xu, Xiangdong, Li, Qun, Zhang, Tianyuan, Hansen, T. Matthew, Liu, Gang, Xin, Zhili, Wang, Xiaojun, Wang, Rongqi, McNally, Teresa, Camp, Heidi, Beutel, Bruce A, Sham, Hing L

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An Ultraefficient Affinity-Based High-Throughout Screening Process: Application to Bacterial Cell Wall Biosynthesis Enzyme MurF von Comess, Kenneth M., Schurdak, Mark E., Voorbach, Martin J., Coen, Michael, Trumbull, Jonathan D., Yang, Houjun, Gao, Lan, Tang, Hua, Cheng, Xueheng, Lerner, Claude G., Mccall, J. Owen, Burns, David J., Beutel, Bruce A.

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Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents von Clark, Richard F., Zhang, Tianyuan, Wang, Xiaojun, Wang, Rongqi, Zhang, Xiaolin, Camp, Heidi S., Beutel, Bruce A., Sham, Hing L., Gu, Yu Gui

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Mechanism of Action of a Novel Series of Naphthyridine-Type Ribosome Inhibitors: Enhancement of tRNA Footprinting at the Decoding Site of 16S rRNA von Shen, Linus L, Black-Schaefer, Candace, Cai, Yingna, Dandliker, Peter J, Beutel, Bruce A

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Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents von Beebe, Xenia, Nilius, Angela M., Merta, Philip J., Soni, Niru B., Bui, Mai H., Wagner, Rolf, Beutel, Bruce A.

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Novel Approach to Mapping of Resistance Mutations in Whole Genomes by Using Restriction Enzyme Modulation of Transformation Efficiency von LERNER, Claude G, KAKAVAS, Stephan J, WAGNER, Christian, CHANG, Richard T, MERTA, Philip J, XIAOAN RUAN, METZGER, Randy E, BEUTEL, Bruce A

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Structural and Functional Characterization of Potent Antithrombotic Oligonucleotides Possessing Both Quadruplex and Duplex Motifs von Macaya, Roman F, Waldron, Janet A, Beutel, Bruce A, Gao, Hetian, Joesten, Michael E, Yang, Meihua, Patel, Rina, Bertelsen, Arthur H, Cook, Alan F

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Structure of MurF from Streptococcus pneumoniae co‐crystallized with a small molecule inhibitor exhibits interdomain closure von Longenecker, Kenton L., Stamper, Geoffrey F., Hajduk, Philip J., Fry, Elizabeth H., Jakob, Clarissa G., Harlan, John E., Edalji, Rohinton, Bartley, Diane M., Walter, Karl A., Solomon, Larry R., Holzman, Thomas F., Gu, Yu Gui, Lerner, Claude G., Beutel, Bruce A., Stoll, Vincent S.

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Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization von Sanders, William J, Nienaber, Vicki L, Lerner, Claude G, McCall, J. Owen, Merrick, Sean M, Swanson, Susan J, Harlan, John E, Stoll, Vincent S, Stamper, Geoffrey F, Betz, Stephen F, Condroski, Kevin R, Meadows, Robert P, Severin, Jean M, Walter, Karl A, Magdalinos, Peter, Jakob, Clarissa G, Wagner, Rolf, Beutel, Bruce A

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N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Acetyl-CoA Carboxylase InhibitorsImprovement of Cardiovascular and Neurological Liabilities via S... von Gu, Yu Gui, Weitzberg, Moshe, Clark, Richard F, Xu, Xiangdong, Li, Qun, Lubbers, Nathan L, Yang, Yi, Beno, David W. A, Widomski, Deborah L, Zhang, Tianyuan, Hansen, T. Matthew, Keyes, Robert F, Waring, Jeffrey F, Carroll, Sherry L, Wang, Xiaojun, Wang, Rongqi, Healan-Greenberg, Christine H, Blomme, Eric A, Beutel, Bruce A, Sham, Hing L, Camp, Heidi S

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The synthesis and structure–activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modificatio... von Xu, Xiangdong, Weitzberg, Moshe, Keyes, Robert F., Li, Qun, Wang, Rongqi, Wang, Xiaojun, Zhang, Xiaolin, Frevert, Ernst U., Camp, Heidi S., Beutel, Bruce A., Sham, Hing L., Gu, Yu Gui

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Novel Antibacterial Class:  A Series of Tetracyclic Derivatives von Hinman, Mira M, Rosenberg, Teresa A, Balli, Darlene, Black-Schaefer, Candace, Chovan, Linda E, Kalvin, Douglas, Merta, Philip J, Nilius, Angela M, Pratt, Steve D, Soni, Niru B, Wagenaar, Frank L, Weitzberg, Moshe, Wagner, Rolf, Beutel, Bruce A

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Structure–activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity von Clark, Richard F., Zhang, Tianyuan, Xin, Zhili, Liu, Gang, Wang, Ying, Hansen, T. Matthew, Wang, Xiaojun, Wang, Rongqi, Zhang, Xiaolin, Frevert, Ernst U., Camp, Heidi S., Beutel, Bruce A., Sham, Hing L., Gu, Yu Gui

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Structure–activity relationships of novel potent MurF inhibitors von Gu, Yu Gui, Florjancic, Alan S., Clark, Richard F., Zhang, Tianyuan, Cooper, Curt S., Anderson, David D., Lerner, Claude G., McCall, J.Owen, Cai, Yingna, Black-Schaefer, Candace L., Stamper, Geoffrey F., Hajduk, Philip J., Beutel, Bruce A.

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Structure-based Optimization of MurF Inhibitors von Stamper, Geoffrey F., Longenecker, Kenton L., Fry, Elizabeth H., Jakob, Clarissa G., Florjancic, Alan S., Gu, Yu-Gui, Anderson, David D., Cooper, Curt S., Zhang, Tianyuan, Clark, Richard F., Cia, Yingna, Black-Schaefer, Candace L., Owen McCall, J., Lerner, Claude G., Hajduk, Philip J., Beutel, Bruce A., Stoll, Vincent S.

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Novel Antibacterial Class von DANDLIKER, Peter J, PRATT, Steve D, CHOVAN, Linda E, HICKMAN, Robert K, DALY, Melissa M, KAKAVAS, Stephan, PING ZHONG, ZHENSHENG CAO, DAVID, Caroline A, XIAOLING XUEI, LERNER, Claude G, SONI, Niru B, NILIUS, Angela M, MAI BUI, SHEN, Linus L, YINGNA CAI, MERTA, Philip J, SAIKI, Anne Y. C, BEUTEL, Bruce A, BLACK-SCHAEFER, Candace, XIAOAN RUAN, TOWNE, Danli L, CLARK, Richard F, ENGLUND, Erika E, WAGNER, Rolf, WEITZBERG, Moshe

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Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors von Gu, Yu Gui, Weitzberg, Moshe, Clark, Richard F, Xu, Xiangdong, Li, Qun, Zhang, Tianyuan, Hansen, T. Matthew, Liu, Gang, Xin, Zhili, Wang, Xiaojun, Wang, Rongqi, McNally, Teresa, Zinker, Bradley A, Frevert, Ernst U, Camp, Heidi S, Beutel, Bruce A, Sham, Hing L

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From Bacterial Genomes to Novel Antibacterial Agents: Discovery, Characterization, and Antibacterial Activity of Compounds that Bind to HI0065 (YjeE) from Haemophilus influenzae von Lerner, Claude G., Hajduk, Philip J., Wagner, Rolf, Wagenaar, Frank L., Woodall, Charlotte, Gu, Yu‐Gui, Searle, Xenia B., Florjancic, Alan S., Zhang, Tianyuan, Clark, Richard F., Cooper, Curt S., Mack, Jamey C., Yu, Liping, Cai, Mengli, Betz, Steven F., Chovan, Linda E., McCall, J. Owen, Black‐Schaefer, Candace L., Kakavas, Stephan J., Schurdak, Mark E., Comess, Kenneth M., Walter, Karl A., Edalji, Rohinton, Dorwin, Sarah A., Smith, Richard A., Hebert, Eric J., Harlan, John E., Metzger, Randy E., Merta, Philip J., Baranowski, John L., Coen, Michael L., Thornewell, Susan J., Shivakumar, Annapur G., Saiki, Anne Y., Soni, Niru, Bui, Mai, Balli, Darlene J., Sanders, William J., Nilius, Angela M., Holzman, Thomas F., Fesik, Stephen W., Beutel, Bruce A.

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