Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets von Bedford, Lynn, Lowe, James, Dick, Lawrence R., Mayer, R. John, Brownell, James E.

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Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ von Brownell, James E., Sintchak, Michael D., Gavin, James M., Liao, Hua, Bruzzese, Frank J., Bump, Nancy J., Soucy, Teresa A., Milhollen, Michael A., Yang, Xiaofeng, Burkhardt, Anne L., Ma, Jingya, Loke, Huay-Keng, Lingaraj, Trupti, Wu, Dongyun, Hamman, Kristin B., Spelman, James J., Cullis, Courtney A., Langston, Steven P., Vyskocil, Stepan, Sells, Todd B., Mallender, William D., Visiers, Irache, Li, Ping, Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Dick, Lawrence R.

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Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation von He, Xingyue, Riceberg, Jessica, Pulukuri, Sai M, Grossman, Steve, Shinde, Vaishali, Shah, Pooja, Brownell, James E, Dick, Larry, Newcomb, John, Bence, Neil

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Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors von Huang, Shih-Chung, Adhikari, Sharmila, Brownell, James E., Calderwood, Emily F., Chouitar, Jouhara, D'Amore, Natalie Roy, England, Dylan B., Foley, Klaudia, Harrison, Sean J., LeRoy, Patrick J., Lok, David, Lublinsky, Anna, Ma, Li-Ting, Menon, Saurabh, Yang, Yu, Zhang, Ji, Gould, Alexandra E.

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Biochemical perspectives on targeting KMT2 methyltransferases in cancer von Zhai, Xiang, Brownell, James E.

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Identification of a lung cancer cell line deficient in atg7-dependent autophagy von Mandelbaum, Jonathan, Rollins, Neil, Shah, Pooja, Bowman, Doug, Lee, Janice Y, Tayber, Olga, Bernard, Hugues, LeRoy, Patrick, Li, Ping, Koenig, Erik, Brownell, James E, D'Amore, Natalie

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Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6 von Gavin, James M., Chen, Jesse J., Liao, Hua, Rollins, Neil, Yang, Xiaofeng, Xu, Qing, Ma, Jingya, Loke, Huay-Keng, Lingaraj, Trupti, Brownell, James E., Mallender, William D., Gould, Alexandra E., Amidon, Benjamin S., Dick, Lawrence R.

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor von He, Xingyue, Riceberg, Jessica, Soucy, Teresa, Koenig, Erik, Minissale, James, Gallery, Melissa, Bernard, Hugues, Yang, Xiaofeng, Liao, Hua, Rabino, Claudia, Shah, Pooja, Xega, Kristina, Yan, Zhong-hua, Sintchak, Mike, Bradley, John, Xu, He, Duffey, Matt, England, Dylan, Mizutani, Hirotake, Hu, Zhigen, Guo, Jianping, Chau, Ryan, Dick, Lawrence R, Brownell, James E, Newcomb, John, Langston, Steve, Lightcap, Eric S, Bence, Neil, Pulukuri, Sai M

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HAT discovery: Heading toward an elusive goal with a key biological assist von Brownell, James E., Allis, C. David

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Special HATs for special occasions: linking histone acetylation to chromatin assembly and gene activation von Brownell, James E, Allis, C David

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Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines von Kuo, Min-Hao, Brownell, James E., Sobel, Richard E., Ranalli, Tamara A., Cook, Richard G., Edmondson, Diane G., Roth, Sharon Y., Allis, C. David

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The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy von Soucy, Teresa A, Dick, Lawrence R, Smith, Peter G, Milhollen, Michael A, Brownell, James E

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Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues von Chen, Jesse J., Tsu, Christopher A., Gavin, James M., Milhollen, Michael A., Bruzzese, Frank J., Mallender, William D., Sintchak, Michael D., Bump, Nancy J., Yang, Xiaofeng, Ma, Jingya, Loke, Huay-Keng, Xu, Qing, Li, Ping, Bence, Neil F., Brownell, James E., Dick, Lawrence R.

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Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation von Brownell, James E, Zhou, Jianxin, Ranalli, Tamara, Kobayashi, Ryuji, Edmondson, Diane G, Roth, Sharon Y, Allis, C.David

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A Sensitive IHC Method for Monitoring Autophagy-Specific Markers in Human Tumor Xenografts von He, Helen, Yang, Yu, Xiang, Zhongmin, Yu, Lunyin, Chouitar, Jouhara, Yu, Jie, D’Amore, Natalie Roy, Li, Ping, Li, Zhi, Bowman, Douglas, Theisen, Matthew, Brownell, James E., Tirrell, Stephen

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Absolute Quantification of E1, Ubiquitin-Like Proteins and Nedd8–MLN4924 Adduct by Mass Spectrometry von Yang, Xiaofeng, Brownell, James E., Xu, Qing, Zhu, Fengying, Ma, Jingya, Loke, Huay-Keng, Rollins, Neil, Soucy, Teresa A., Minissale, James J., Thomas, Michael P., Mallender, William D., Dick, Lawrence R., Li, Ping, Liao, Hua

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer von Soucy, Teresa A., Smith, Peter G., Milhollen, Michael A., Berger, Allison J., Gavin, James M., Adhikari, Sharmila, Brownell, James E., Burke, Kristine E., Cardin, David P., Critchley, Stephen, Cullis, Courtney A., Doucette, Amanda, Garnsey, James J., Gaulin, Jeffrey L., Gershman, Rachel E., Lublinsky, Anna R., McDonald, Alice, Mizutani, Hirotake, Narayanan, Usha, Olhava, Edward J., Peluso, Stephane, Rezaei, Mansoureh, Sintchak, Michael D., Talreja, Tina, Thomas, Michael P., Traore, Tary, Vyskocil, Stepan, Weatherhead, Gabriel S., Yu, Jie, Zhang, Julie, Dick, Lawrence R., Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Langston, Steven P.

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An Activity Gel Assay Detects a Single, Catalytically Active Histone Acetyltransferase Subunit in Tetrahymena Macronuclei von Brownell, J E, Allis, C D

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A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination von Podust, V N, Brownell, J E, Gladysheva, T B, Luo, R S, Wang, C, Coggins, M B, Pierce, J W, Lightcap, E S, Chau, V

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A Novel H2A/H4 Nucleosomal Histone Acetyltransferase in Tetrahymena thermophila von Ohba, Reiko, Steger, David J., Brownell, James E., Mizzen, Craig A., Cook, Richard G., Côté, Jacques, Workman, Jerry L., Allis, C. David

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