Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice von Pryde, David C, Jones, Lyn H, Gervais, David P, Stead, David R, Blakemore, David C, Selby, Matthew D, Brown, Alan D, Coe, Jotham W, Badland, Matthew, Beal, David M, Glen, Rebecca, Wharton, Yvonne, Miller, Gavin J, White, Phil, Zhang, Ningli, Benoit, Michelle, Robertson, Karen, Merson, James R, Davis, Heather L, McCluskie, Michael J

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A 28 Day Clinical Assessment of a Lactic Acid-containing Antimicrobial Intimate Gel Wash Formulation on Skin Tolerance and Impact on the Vulvar Microbiome von Bruning, Elizabeth, Chen, Ying, McCue, Karen A., Rubino, Joseph R., Wilkinson, Jeremy E., Brown, Alan D. G.

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Dual Kv7.2/3-TRPV1 modulators inhibit nociceptor hyperexcitability and alleviate pain without target-related side effects von Raveh, Adi, Pen, Yefim, Silberman, Alon, Peretz, Asher, Attali, Bernard, Maile, Laura, Davidson, Steve, Brown, Alan D, Kennedy, Jeffrey D, Belinson, Haim

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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective von Bagal, Sharan K, Brown, Alan D, Cox, Peter J, Omoto, Kiyoyuki, Owen, Robert M, Pryde, David C, Sidders, Benjamin, Skerratt, Sarah E, Stevens, Edward B, Storer, R. Ian, Swain, Nigel A

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Metal-Free Coupling of Saturated Heterocyclic Sulfonylhydrazones with Boronic Acids von Allwood, Daniel M, Blakemore, David C, Brown, Alan D, Ley, Steven V

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Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel. A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R. G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R. Ian, Stupple, Paul A, West, Christopher W

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Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity von Mowbray, Charles E, Braillard, Stéphanie, Speed, William, Glossop, Paul A, Whitlock, Gavin A, Gibson, Karl R, Mills, James E. J, Brown, Alan D, Gardner, J. Mark F, Cao, Yafeng, Hua, Wen, Morgans, Garreth L, Feijens, Pim-Bart, Matheeussen, An, Maes, Louis J

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Is Fifty Really the New Thirty? The Stigma of Age as a Form of Strain and its Role in Drug and Alcohol Abuse and Dependence by Women von Black, Pamela, Brown, Alan D.

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The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain von Brown, Alan D., Bagal, Sharan K., Blackwell, Paul, Blakemore, David C., Brown, Bruce, Bungay, Peter J., Corless, Martin, Crawforth, James, Fengas, David, Fenwick, David R., Gray, Victoria, Kemp, Mark, Klute, Wolfgang, Malet Sanz, Laia, Miller, Duncan, Murata, Yoshihisa, Payne, C. Elizabeth, Skerratt, Sarah, Stevens, Edward B., Warmus, Joseph S.

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Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes von Storer, R. Ian, Pike, Andy, Swain, Nigel A., Alexandrou, Aristos J., Bechle, Bruce M., Blakemore, David C., Brown, Alan D., Castle, Neil A., Corbett, Matthew S., Flanagan, Neil J., Fengas, David, Johnson, M. Scott, Jones, Lyn H., Marron, Brian E., Payne, C. Elizabeth, Printzenhoff, David, Rawson, David J., Rose, Colin R., Ryckmans, Thomas, Sun, Jianmin, Theile, Jonathan W., Torella, Rubben, Tseng, Elaine, Warmus, Joseph S.

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Multiparameter Optimization in CNS Drug Discovery: Design of Pyrimido[4,5‑d]azepines as Potent 5‑Hydroxytryptamine 2C (5-HT2C) Receptor Agonists with Exquisite Functional Selectivi... von Storer, R. Ian, Brennan, Paul E, Brown, Alan D, Bungay, Peter J, Conlon, Kelly M, Corbett, Matthew S, DePianta, Robert P, Fish, Paul V, Heifetz, Alexander, Ho, Danny K. H, Jessiman, Alan S, McMurray, Gordon, de Oliveira, Cesar Augusto F, Roberts, Lee R, Root, James A, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Skerten, Melanie, Westbrook, Dominique, Wheeler, Simon, Whitlock, Gavin A, Wright, John

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Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles von Miller, Duncan C., Klute, Wolfgang, Brown, Alan D.

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Inhalation by design: novel ultra-long-acting β(2)-adrenoreceptor agonists for inhaled once-daily treatment of asthma and chronic obstructive pulmonary disease that utilize a sulfo... von Glossop, Paul A, Lane, Charlotte A L, Price, David A, Bunnage, Mark E, Lewthwaite, Russell A, James, Kim, Brown, Alan D, Yeadon, Michael, Perros-Huguet, Christelle, Trevethick, Michael A, Clarke, Nicholas P, Webster, Robert, Jones, Rhys M, Burrows, Jane L, Feeder, Neil, Taylor, Stefan C J, Spence, Fiona J

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Inhalation by Design: Novel Ultra-Long-Acting β2-Adrenoreceptor Agonists for Inhaled Once-Daily Treatment of Asthma and Chronic Obstructive Pulmonary Disease That Utilize a Sulfona... von Glossop, Paul A, Lane, Charlotte A. L, Price, David A, Bunnage, Mark E, Lewthwaite, Russell A, James, Kim, Brown, Alan D, Yeadon, Michael, Perros-Huguet, Christelle, Trevethick, Michael A, Clarke, Nicholas P, Webster, Robert, Jones, Rhys M, Burrows, Jane L, Feeder, Neil, Taylor, Stefan C. J, Spence, Fiona J

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7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization von Fish, Paul V, Brown, Alan D, Evrard, Edel, Roberts, Lee R

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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Dia... von Swain, Nigel A, Batchelor, Dave, Beaudoin, Serge, Bechle, Bruce M, Bradley, Paul A, Brown, Alan D, Brown, Bruce, Butcher, Ken J, Butt, Richard P, Chapman, Mark L, Denton, Stephen, Ellis, David, Galan, Sebastien R G, Gaulier, Steven M, Greener, Ben S, de Groot, Marcel J, Glossop, Mel S, Gurrell, Ian K, Hannam, Jo, Johnson, Matthew S, Lin, Zhixin, Markworth, Christopher J, Marron, Brian E, Millan, David S, Nakagawa, Shoko, Pike, Andy, Printzenhoff, David, Rawson, David J, Ransley, Sarah J, Reister, Steven M, Sasaki, Kosuke, Storer, R Ian, Stupple, Paul A, West, Christopher W

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Optimising metabolic stability in lipophilic chemical space: The identification of a metabolically stable pyrazolopyrimidine CRF-1 receptor antagonist von Miller, Duncan C., Klute, Wolfgang, Calabrese, Andrew, Brown, Alan D.

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Discovery of a Selective Small-Molecule Melanocortin-4 Receptor Agonist with Efficacy in a Pilot Study of Sexual Dysfunction in Humans von Lansdell, Mark I, Hepworth, David, Calabrese, Andrew, Brown, Alan D, Blagg, Julian, Burring, Denise J, Wilson, Peter, Fradet, David, Brown, T. Bruce, Quinton, Faye, Mistry, Neela, Tang, Kim, Mount, Natalie, Stacey, Peter, Edmunds, Nick, Adams, Cathryn, Gaboardi, Samantha, Neal-Morgan, Stevie, Wayman, Chris, Cole, Susan, Phipps, Joanne, Lewis, Mark, Verrier, Hugh, Gillon, Val, Feeder, Neil, Heatherington, Anne, Sultana, Stefan, Haughie, Scott, Martin, Steven W, Sudworth, Maria, Tweedy, Sarah

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Designing drugs for the treatment of female sexual dysfunction von Brown, Alan D., Blagg, Julian, Reynolds, David S.

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Utilization of preoperative urodynamic investigations by gynecologists who frequently operate for female urinary incontinence von Duggan, Paul M., Wilson, P. Don, Norton, Peggy, Brown, Alan D. G., Drutz, Harold P, Herbison, Peter

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