The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin von Wadsworth, John M, Clarke, David J, McMahon, Stephen A, Lowther, Jonathan P, Beattie, Ashley E, Langridge-Smith, Pat R. R, Broughton, Howard B, Dunn, Teresa M, Naismith, James H, Campopiano, Dominic J

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A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen–Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein–Ligand Interactions... von Saltzberg, Daniel J, Broughton, Howard B, Pellarin, Riccardo, Chalmers, Michael J, Espada, Alfonso, Dodge, Jeffrey A, Pascal, Bruce D, Griffin, Patrick R, Humblet, Christine, Sali, Andrej

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The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage von Jin, Najia, Matter, William F, Michael, Laura F, Qian, Yuewei, Gheyi, Tarun, Cano, Leticia, Perez, Carlos, Lafuente, Celia, Broughton, Howard B, Espada, Alfonso

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Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt) von Lugar, Charles W, Clarke, Christian A, Morphy, Richard, Rudyk, Helene, Sapmaz, Selma, Stites, Ryan E, Vaught, Grant M, Furness, Kelly, Broughton, Howard B, Durst, Greg L, Clawson, David K, Stout, Stephanie L, Guo, Sherry Y, Durbin, Jim D, Stayrook, Keith R, Edmondson, Denise D, Kikly, Kristy, New, Nicole E, Bina, Holly A, Chambers, Mark G, Shetler, Pamela, Chang, William Y, Chang, Veavi Ching-Yun, Barr, Rob, Gough, Wendy H, Steele, Jimmy P, Getman, Brian, Patel, Nita, Mathes, Brian M, Richardson, Timothy I

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5-(4-Chlorophenyl)-4-methyl-3-(1-(2- phenylethyl)piperidin-4-yl)isoxazole:  A Potent, Selective Antagonist at Human Cloned Dopamine D4 Receptors von Rowley, Michael, Broughton, Howard B, Collins, Ian, Baker, Raymond, Emms, Frances, Marwood, Rosemarie, Patel, Shil, Patel, Smita, Ragan, C. Ian, Freedman, Stephen B, Leeson, Paul D

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Selection of heterocycles for drug design von Broughton, Howard B., Watson, Ian A.

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Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition von Chambers, Mark S, Atack, John R, Broughton, Howard B, Collinson, Neil, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Marshall, George, Maubach, Karen A, Pillai, Goplan V, Reeve, Austin J, MacLeod, Angus M

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Controlled Modification of Acidity in Cholecystokinin B Receptor Antagonists:  N-(1,4-Benzodiazepin-3-yl)-N ‘-[3-(tetrazol-5-ylamino)phenyl]ureas von Castro, José L, Ball, Richard G, Broughton, Howard B, Russell, Michael G. N, Rathbone, Denise, Watt, Alan P, Baker, Raymond, Chapman, Kerry L, Fletcher, Alan E, Patel, Smita, Smith, Alison J, Marshall, George R, Ryecroft, Wayne, Matassa, Victor G

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N-Arylsulfonylindole Derivatives as Serotonin 5-HT6 Receptor Ligands von Russell, Michael G. N, Baker, Robert J, Barden, Laura, Beer, Margaret S, Bristow, Linda, Broughton, Howard B, Knowles, Michael, McAllister, George, Patel, Smita, Castro, José L

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A method for including protein flexibility in protein-ligand docking: improving tools for database mining and virtual screening von Broughton, Howard B.

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Molecular binding interactions: their estimation and rationalization in QSARs in terms of theoretically derived parameters von Lewis, David F V, Broughton, Howard B

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Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved Pharmacokinetic Profiles von van Niel, Monique B, Collins, Ian, Beer, Margaret S, Broughton, Howard B, Cheng, Susan K. F, Goodacre, Simon C, Heald, Anne, Locker, Karen L, MacLeod, Angus M, Morrison, Denise, Moyes, Christopher R, O'Connor, Desmond, Pike, Andrew, Rowley, Michael, Russell, Michael G. N, Sohal, Balbinder, Stanton, Josephine A, Thomas, Steven, Verrier, Hugh, Watt, Alan P, Castro, José L

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3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine:  An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 Receptor von Kulagowski, Janusz J, Broughton, Howard B, Curtis, Neil R, Mawer, Ian M, Ridgill, Mark P, Baker, Raymond, Emms, Frances, Freedman, Stephen B, Marwood, Rosemarie, Patel, Shil, Patel, Smita, Ragan, C. Ian, Leeson, Paul D

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Chemistry of sulfones: synthesis of a new chiral nucleophilic catalyst von Díez, David, Gil, Maria J., Moro, Rosalina F., Garrido, Narciso M., Marcos, Isidro S., Basabe, Pilar, Sanz, Francisca, Broughton, Howard B., Urones, Julio G.

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Stereocontrolled Synthesis of Cyclopropanol Amino Acids from Allylic Sulfones:  Conformationally Restricted Building Blocks von Díez, David, Garcia, P, Marcos, Isidro S, Garrido, N. M, Basabe, P, Broughton, Howard B, Urones, Julio G

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6,7-Dihydro-2-benzothiophen-4(5H)-ones:  A Novel Class of GABA-A α5 Receptor Inverse Agonists von Chambers, Mark S, Atack, John R, Bromidge, Frances A, Broughton, Howard B, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Maubach, Karen A, Reeve, Austin J, Seabrook, Guy R, Wafford, Keith, MacLeod, Angus M

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Chemistry of Epoxysulfones:  Straightforward Synthesis of Versatile Chiral Building Blocks von Díez, David, Benéitez, M. Templo, Marcos, Isidro S, Garrido, N. M, Basabe, P, Sanz, F, Broughton, Howard B, Urones, Julio G

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New Selective Cytotoxic Diterpenylquinones and Diterpenylhydroquinones von Miguel del Corral, José Ma, Gordaliza, Marina, Castro, Ma Angeles, Mahiques, Ma Mar, Chamorro, Pablo, Molinari, Aurora, García-Grávalos, Ma Dolores, Broughton, Howard B, San Feliciano, Arturo

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Structure and mechanism of inositol monophosphatase von Atack, John R., Broughton, Howard B., Pollack, Scott J.

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4-Heterocyclylpiperidines as Selective High-Affinity Ligands at the Human Dopamine D4 Receptor von Rowley, Michael, Collins, Ian, Broughton, Howard B, Davey, William B, Baker, Raymond, Emms, Frances, Marwood, Rosemarie, Patel, Shil, Patel, Smita, Ragan, C. Ian, Freedman, Stephen B, Ball, Richard, Leeson, Paul D

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