A Residue-Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen–Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein–Ligand Interactions... von Saltzberg, Daniel J, Broughton, Howard B, Pellarin, Riccardo, Chalmers, Michael J, Espada, Alfonso, Dodge, Jeffrey A, Pascal, Bruce D, Griffin, Patrick R, Humblet, Christine, Sali, Andrej

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The Chemical Basis of Serine Palmitoyltransferase Inhibition by Myriocin von Wadsworth, John M, Clarke, David J, McMahon, Stephen A, Lowther, Jonathan P, Beattie, Ashley E, Langridge-Smith, Pat R. R, Broughton, Howard B, Dunn, Teresa M, Naismith, James H, Campopiano, Dominic J

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Benchmarking causal reasoning algorithms for gene expression-based compound mechanism of action analysis von Hosseini-Gerami, Layla, Higgins, Ixavier Alonzo, Collier, David A, Laing, Emma, Evans, David, Broughton, Howard, Bender, Andreas

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MAVEN: compound mechanism of action analysis and visualisation using transcriptomics and compound structure data in R/Shiny von Hosseini-Gerami, Layla, Hernansaiz Ballesteros, Rosa, Liu, Anika, Broughton, Howard, Collier, David Andrew, Bender, Andreas

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The Angiopoietin-Like Protein 3 and 8 Complex Interacts with Lipoprotein Lipase and Induces LPL Cleavage von Jin, Najia, Matter, William F, Michael, Laura F, Qian, Yuewei, Gheyi, Tarun, Cano, Leticia, Perez, Carlos, Lafuente, Celia, Broughton, Howard B, Espada, Alfonso

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Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage von Pandya, Priyanka, Sayers, Robert O, Ting, Joey P, Morshedian, Shaghayegh, Torres, Carina, Cudal, Justine S, Zhang, Kai, Fitchett, Jonathan R, Zhang, Qing, Zhang, Feiyu F, Wang, Jing, Durbin, Jim D, Carrillo, Juan J, Espada, Alfonso, Broughton, Howard, Qian, Yuewei, Afshar, Sepideh

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Defining Target Engagement Required for Efficacy In Vivo at the Retinoic Acid Receptor-Related Orphan Receptor C2 (RORγt) von Lugar, Charles W, Clarke, Christian A, Morphy, Richard, Rudyk, Helene, Sapmaz, Selma, Stites, Ryan E, Vaught, Grant M, Furness, Kelly, Broughton, Howard B, Durst, Greg L, Clawson, David K, Stout, Stephanie L, Guo, Sherry Y, Durbin, Jim D, Stayrook, Keith R, Edmondson, Denise D, Kikly, Kristy, New, Nicole E, Bina, Holly A, Chambers, Mark G, Shetler, Pamela, Chang, William Y, Chang, Veavi Ching-Yun, Barr, Rob, Gough, Wendy H, Steele, Jimmy P, Getman, Brian, Patel, Nita, Mathes, Brian M, Richardson, Timothy I

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Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery von Ting, Joey P, Tung, Frances, Antonysamy, Stephen, Wasserman, Stephen, Jones, Spencer B, Zhang, Feiyu F, Espada, Alfonso, Broughton, Howard, Chalmers, Michael J, Woodman, Michael E, Bina, Holly A, Dodge, Jeffrey A, Benach, Jordi, Zhang, Aiping, Groshong, Christopher, Manglicmot, Danalyn, Russell, Marijane, Afshar, Sepideh

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Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b von Hosseini-Gerami, Layla, Ficulle, Elena, Humphryes-Kirilov, Neil, Airey, David C, Scherschel, James, Kananathan, Sarubini, Eastwood, Brian J, Bose, Suchira, Collier, David A, Laing, Emma, Evans, David, Broughton, Howard, Bender, Andreas

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Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy von Gharbi, Severine Isabelle, Pelletier, Laura A., Espada, Alfonso, Gutiérrez, Jesus, Sanfeliciano, Sonia Maria Gutiérrez, Rauch, Charles T., Ganado, Maria Patricia, Baquero, Carmen, Zapatero, Elisabet, Zhang, Aiping, Benach, Jordi, Russell, Anna-Maria, Cano, Leticia, Gomez, Sandra, Broughton, Howard, Pulliam, Nicholas, Perez, Carmen Maria, Torres, Raquel, Debets, Marjoke F., de Dios, Alfonso, Puig, Oscar, Hilgers, Mark T., Lallena, Maria Jose

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Selection of heterocycles for drug design von Broughton, Howard B., Watson, Ian A.

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Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition von Chambers, Mark S, Atack, John R, Broughton, Howard B, Collinson, Neil, Cook, Susan, Dawson, Gerard R, Hobbs, Sarah C, Marshall, George, Maubach, Karen A, Pillai, Goplan V, Reeve, Austin J, MacLeod, Angus M

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Author Correction: Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacy von Gharbi, Severine Isabelle, Pelletier, Laura A., Espada, Alfonso, Gutiérrez, Jesus, Sanfeliciano, Sonia Maria Gutiérrez, Rauch, Charles T., Ganado, Maria Patricia, Baquero, Carmen, Zapatero, Elisabet, Zhang, Aiping, Benach, Jordi, Russell, Anna-Maria, Cano, Leticia, Gomez, Sandra, Broughton, Howard, Pulliam, Nicholas, Perez, Carmen Maria, Torres, Raquel, Debets, Marjoke F., de Dios, Alfonso, Puig, Oscar, Hilgers, Mark T., Lallena, Maria Jose

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Synthesis of 2-Amino-5-arylthiazoles by Palladium-Catalyzed Arylation at the C5 Position with Aryl Iodides von Priego, Julián, Gutiérrez, Sonia, Ferritto, Rafael, Broughton, Howard B.

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N-Arylsulfonylindole Derivatives as Serotonin 5-HT6 Receptor Ligands von Russell, Michael G. N, Baker, Robert J, Barden, Laura, Beer, Margaret S, Bristow, Linda, Broughton, Howard B, Knowles, Michael, McAllister, George, Patel, Smita, Castro, José L

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Fluorination of 3-(3-(Piperidin-1-yl)propyl)indoles and 3-(3-(Piperazin-1-yl)propyl)indoles Gives Selective Human 5-HT1D Receptor Ligands with Improved Pharmacokinetic Profiles von van Niel, Monique B, Collins, Ian, Beer, Margaret S, Broughton, Howard B, Cheng, Susan K. F, Goodacre, Simon C, Heald, Anne, Locker, Karen L, MacLeod, Angus M, Morrison, Denise, Moyes, Christopher R, O'Connor, Desmond, Pike, Andrew, Rowley, Michael, Russell, Michael G. N, Sohal, Balbinder, Stanton, Josephine A, Thomas, Steven, Verrier, Hugh, Watt, Alan P, Castro, José L

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3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine:  An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 Receptor von Kulagowski, Janusz J, Broughton, Howard B, Curtis, Neil R, Mawer, Ian M, Ridgill, Mark P, Baker, Raymond, Emms, Frances, Freedman, Stephen B, Marwood, Rosemarie, Patel, Shil, Patel, Smita, Ragan, C. Ian, Leeson, Paul D

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5-(4-Chlorophenyl)-4-methyl-3-(1-(2- phenylethyl)piperidin-4-yl)isoxazole:  A Potent, Selective Antagonist at Human Cloned Dopamine D4 Receptors von Rowley, Michael, Broughton, Howard B, Collins, Ian, Baker, Raymond, Emms, Frances, Marwood, Rosemarie, Patel, Shil, Patel, Smita, Ragan, C. Ian, Freedman, Stephen B, Leeson, Paul D

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A method for including protein flexibility in protein-ligand docking: improving tools for database mining and virtual screening von Broughton, Howard B.

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A novel phage display vector for selection of target-specific peptides von Chang, Alex, Ting, Joey P, Espada, Alfonso, Broughton, Howard, Molina-Martin, Manuel, Afshar, Sepideh

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