Inhibiting the NLRP3 Inflammasome von El-Sharkawy, Lina Y., Brough, David, Freeman, Sally

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Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming von Green, Jack P., Yu, Shi, Martín-Sánchez, Fátima, Pelegrin, Pablo, Lopez-Castejon, Gloria, Lawrence, Catherine B., Brough, David

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AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 von Denes, Adam, Coutts, Graham, Lénárt, Nikolett, Cruickshank, Sheena M., Pelegrin, Pablo, Skinner, Joanne, Rothwell, Nancy, Allan, Stuart M., Brough, David

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Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways von Rivers‐Auty, Jack, Brough, David

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Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models von Daniels, Michael J. D., Rivers-Auty, Jack, Schilling, Tom, Spencer, Nicholas G., Watremez, William, Fasolino, Victoria, Booth, Sophie J., White, Claire S., Baldwin, Alex G., Freeman, Sally, Wong, Raymond, Latta, Clare, Yu, Shi, Jackson, Joshua, Fischer, Nicolas, Koziel, Violette, Pillot, Thierry, Bagnall, James, Allan, Stuart M., Paszek, Pawel, Galea, James, Harte, Michael K., Eder, Claudia, Lawrence, Catherine B., Brough, David

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Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro von Gritsenko, Anna, Yu, Shi, Martin-Sanchez, Fatima, Diaz-Del-Olmo, Ines, Nichols, Eva-Maria, Davis, Daniel M, Brough, David, Lopez-Castejon, Gloria

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Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices von Girard, Sylvie, Brough, David, Lopez-Castejon, Gloria, Giles, James, Rothwell, Nancy J., Allan, Stuart M.

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Role of materials data science and informatics in accelerated materials innovation von Kalidindi, Surya R., Brough, David B., Li, Shengyen, Cecen, Ahmet, Blekh, Aleksandr L., Congo, Faical Yannick P., Campbell, Carelyn

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Loss of hepatocyte cell division leads to liver inflammation and fibrosis von Dewhurst, Matthew R., Ow, Jin Rong, Zafer, Gozde, van Hul, Noemi K. M., Wollmann, Heike, Bisteau, Xavier, Brough, David, Choi, Hyungwon, Kaldis, Philipp

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NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury von Savage, Catherine Diane, Lopez-Castejon, Gloria, Denes, Adam, Brough, David

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Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions von Wellens, Rose, Tapia, Victor S., Seoane, Paula I., Bennett, Hayley, Adamson, Antony, Coutts, Graham, Rivers-Auty, Jack, Lowe, Martin, Green, Jack P., Lopez-Castejon, Gloria, Brough, David, Hoyle, Christopher

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Unconventional Pathways of Secretion Contribute to Inflammation von Daniels, Michael J D, Brough, David

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Understanding the mechanism of IL-1β secretion von Lopez-Castejon, Gloria, Brough, David

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Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors von González-Cofrade, Laura, P. Green, Jack, Cuadrado, Irene, Amesty, Ángel, Oramas-Royo, Sandra, David Brough, Estévez-Braun, Ana, Hortelano, Sonsoles, de las Heras, Beatriz

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Pyroptosis leads to loss of centrosomal integrity in macrophages von Bai, Siyi, Martin-Sanchez, Fatima, Brough, David, Lopez-Castejon, Gloria

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Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues von Luheshi, Nadia M, Kovács, Krisztina J, Lopez-Castejon, Gloria, Brough, David, Denes, Adam

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Haematopoietic stem cell gene therapy with IL‐1Ra rescues cognitive loss in mucopolysaccharidosis IIIA von Parker, Helen, Ellison, Stuart M, Holley, Rebecca J, O'Leary, Claire, Liao, Aiyin, Asadi, Jalal, Glover, Emily, Ghosh, Arunabha, Jones, Simon, Wilkinson, Fiona L, Brough, David, Pinteaux, Emmanuel, Boutin, Hervé, Bigger, Brian W

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Regulation of interleukin-1 in acute brain injury von Brough, David, Tyrrell, Pippa J, Allan, Stuart M

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Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis von Diamond, Catherine E., Leong, Keith Weng Kit, Vacca, Maurizio, Rivers-Auty, Jack, Brough, David, Mortellaro, Alessandra

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A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation von Nizami, Sohaib, Millar, Val, Arunasalam, Kanisa, Zarganes-Tzitzikas, Tryfon, Brough, David, Tresadern, Gary, Brennan, Paul E., Davis, John B., Ebner, Daniel, Di Daniel, Elena

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