Bipyridyl- and Biphenyl-DNA: A Recognition Motif Based on Interstrand Aromatic Stacking von Brotschi, Christine, Mathis, Gérald, Leumann, Christian J.

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tethering mechanism for length control in a processive carbohydrate polymerization von May, John F, Splain, Rebecca A, Brotschi, Christine, Kiessling, Laura L

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Pentafluorophenyl-Phenyl Interactions in Biphenyl-DNA von Zahn, Alain, Brotschi, Christine, Leumann, Christian J.

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Structure-Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT-462206: a Potent, Brain-Penetrant Dual Orexin 1/Orexin 2 Receptor A... von Boss, Christoph, Roch-Brisbare, Catherine, Steiner, Michel A., Treiber, Alexander, Dietrich, Hendrik, Jenck, Francois, von Raumer, Markus, Sifferlen, Thierry, Brotschi, Christine, Heidmann, Bibia, Williams, Jodi T., Aissaoui, Hamed, Siegrist, Romain, Gatfield, John

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A Stable DNA Duplex Containing a Non-Hydrogen-Bonding and Non-Shape-Complementary Base Couple: Interstrand Stacking as the Stability Determining Factor von Brotschi, Christine, Häberli, Adrian, Leumann, Christian J.

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Discovery of Nivasorexant (ACT-539313): The First Selective Orexin‑1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials von Williams, Jodi T., Bolli, Martin H., Brotschi, Christine, Sifferlen, Thierry, Steiner, Michel A., Treiber, Alexander, Gatfield, John, Boss, Christoph

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Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases von Lescop, Cyrille, Birker, Magdalena, Brotschi, Christine, Bürki, Cédric, Morrison, Keith, Froidevaux, Sylvie, Delahaye, Stéphane, Nayler, Oliver, Bolli, Martin H.

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Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4‑(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, wi... von Lescop, Cyrille, Brotschi, Christine, Williams, Jodi T., Sager, Christoph P., Birker, Magdalena, Morrison, Keith, Froidevaux, Sylvie, Delahaye, Stéphane, Nayler, Oliver, Bolli, Martin H.

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The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders von Boss, Christoph, Gatfield, John, Brotschi, Christine, Heidmann, Bibia, Sifferlen, Thierry, Raumer, Markus, Schmidt, Gunther, Williams, Jodi T., Treiber, Alexander, Roch, Catherine

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Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in rats von Brotschi, Christine, Bolli, Martin H, Gatfield, John, Roch, Catherine, Sifferlen, Thierry, Treiber, Alexander, Williams, Jodi T, Boss, Christoph

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Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure–Activity Relationships, and Sleep‐Promoting Properties in Rats von Brotschi, Christine, Roch, Catherine, Gatfield, John, Treiber, Alexander, Williams, Jodi T., Sifferlen, Thierry, Heidmann, Bibia, Jenck, Francois, Bolli, Martin H., Boss, Christoph

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From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs von Brotschi, Christine, Bolli, Martin H., Gatfield, John, Heidmann, Bibia, Jenck, Francois, Roch, Catherine, Sifferlen, Thierry, Treiber, Alexander, Williams, Jodi T., Boss, Christoph

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Front Cover: The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders (ChemMedChem 23/2020) von Boss, Christoph, Gatfield, John, Brotschi, Christine, Heidmann, Bibia, Sifferlen, Thierry, Raumer, Markus, Schmidt, Gunther, Williams, Jodi T., Treiber, Alexander, Roch, Catherine

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Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2 von Sifferlen, Thierry, Boller, Amandine, Chardonneau, Audrey, Cottreel, Emmanuelle, Gatfield, John, Treiber, Alexander, Roch, Catherine, Jenck, Francois, Aissaoui, Hamed, Williams, Jodi T, Brotschi, Christine, Heidmann, Bibia, Siegrist, Romain, Boss, Christoph

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A uniquely efficacious type of CFTR corrector with complementary mode of action von Marchesin, Valentina, Monnier, Lucile, Blattmann, Peter, Chevillard, Florent, Kuntz, Christine, Forny, Camille, Kamper, Judith, Studer, Rolf, Bossu, Alexandre, Ertel, Eric A, Nayler, Oliver, Brotschi, Christine, Williams, Jodi T, Gatfield, John

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DNA with Hydrophobic Base Substitutes: A Stable, Zipperlike Recognition Motif Based On Interstrand-Stacking Interactions von Brotschi, Christine, Leumann, Christian J.

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Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach von Heidmann, Bibia, Gatfield, John, Roch, Catherine, Treiber, Alexander, Tortoioli, Simone, Brotschi, Christine, Williams, Jodi T., Bolli, Martin H., Abele, Stefan, Sifferlen, Thierry, Jenck, François, Boss, Christoph

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Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic st... von Sifferlen, Thierry, Boller, Amandine, Chardonneau, Audrey, Cottreel, Emmanuelle, Hoecker, Johannes, Aissaoui, Hamed, Williams, Jodi T, Brotschi, Christine, Heidmann, Bibia, Siegrist, Romain, Gatfield, John, Treiber, Alexander, Brisbare-Roch, Catherine, Jenck, Francois, Boss, Christoph

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Cover Picture: Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold-Hopping Approach (ChemMedChem 19/2016) von Heidmann, Bibia, Gatfield, John, Roch, Catherine, Treiber, Alexander, Tortoioli, Simone, Brotschi, Christine, Williams, Jodi T., Bolli, Martin H., Abele, Stefan, Sifferlen, Thierry, Jenck, François, Boss, Christoph

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Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists von Williams, Jodi T., Gatfield, John, Roch, Catherine, Treiber, Alexander, Jenck, Francois, Bolli, Martin H., Brotschi, Christine, Sifferlen, Thierry, Heidmann, Bibia, Boss, Christoph

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