Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice von Benvenga, Mark J., Chaney, Stephen F., Baez, Melvyn, Britton, Thomas C., Hornback, William J., Monn, James A., Marek, Gerard J.

Volltext

Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor:  Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfony... von Johnson, Michael P, Baez, Melvyn, Jagdmann, G. Erik, Britton, Thomas C, Large, Thomas H, Callagaro, David O, Tizzano, Joseph P, Monn, James A, Schoepp, Darryle D

Volltext

Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s) von Johnson, Michael P, Barda, David, Britton, Thomas C, Emkey, Renee, Hornback, William J, Jagdmann, G Erik, McKinzie, David L, Nisenbaum, Eric S, Tizzano, Joseph P, Schoepp, Darryle D

Volltext

Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies bet... von Caraci, Filippo, Molinaro, Gemma, Battaglia, Giuseppe, Giuffrida, Maria Laura, Riozzi, Barbara, Traficante, Anna, Bruno, Valeria, Cannella, Milena, Merlo, Sara, Wang, Xushan, Heinz, Beverly A, Nisenbaum, Eric S, Britton, Thomas C, Drago, Filippo, Sortino, Maria Angela, Copani, Agata, Nicoletti, Ferdinando

Volltext

Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabo... von Chappell, Mark D, Li, Renhua, Smith, Stephon C, Dressman, Bruce A, Tromiczak, Eric G, Tripp, Allie E, Blanco, Maria-Jesus, Vetman, Tatiana, Quimby, Steven J, Matt, James, Britton, Thomas C, Fivush, Adam M, Schkeryantz, Jeffrey M, Mayhugh, Daniel, Erickson, Jon A, Bures, Mark G, Jaramillo, Carlos, Carpintero, Mercedes, Diego, José Eugenio de, Barberis, Mario, Garcia-Cerrada, Susana, Soriano, José F, Antonysamy, Stephen, Atwell, Shane, MacEwan, Iain, Condon, Bradley, Sougias, Christine, Wang, Jing, Zhang, Aiping, Conners, Kris, Groshong, Chris, Wasserman, Stephen R, Koss, John W, Witkin, Jeffrey M, Li, Xia, Overshiner, Carl, Wafford, Keith A, Seidel, Wesley, Wang, Xu-Shan, Heinz, Beverly A, Swanson, Steven, Catlow, John T, Bedwell, David W, Monn, James A, Mitch, Charles H, Ornstein, Paul L

Volltext

The asymmetric synthesis of .alpha.-amino acids. Electrophilic azidation of chiral imide enolates, a practical approach to the synthesis of (R)- and (S)-.alpha.-azido carboxylic ac... von Evans, David A, Britton, Thomas C, Ellman, Jonathan A, Dorow, Roberta L

Volltext

REM sleep behavior disorder and the risk of developing Parkinson disease or dementia von Britton, Thomas C, Chaudhuri, K Ray

Volltext

Potent and Selective 1,2,3-Trisubstituted Indole NPY Y-1 Antagonists von Hipskind, Philip A, Lobb, Karen L, Nixon, James A, Britton, Thomas C, Bruns, Robert F, Catlow, John, Dieckman-McGinty, Donna K, Gackenheimer, Susan L, Gitter, Bruce D, Iyengar, Smriti, Schober, Douglas A, Simmons, Rosa M. A, Swanson, Steve, Zarrinmayeh, Hamideh, Zimmerman, Dennis M, Gehlert, Donald R

Volltext

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor neg... von Hao, Junliang, Dehlinger, Veronique, Fivush, Adam M., Rudyk, Helene C.E., Britton, Thomas C., Hollinshead, Sean P., Vokits, Benjamin P., Clark, Barry P., Henry, Steven S., Massey, Steven M., Peng, Langu, Dressman, Bruce A., Heinz, Beverly A., Roberts, Edda F., Bracey-Walker, Mallorie R., Swanson, Steven, Catlow, John T., Love, Patrick L., Tepool, Anita D., Peters, Steven C., Simmons, Rosa Maria A., Iyengar, Smriti, McKinzie, David L., Monn, James A.

Volltext

Stereoselective amination of chiral enolates. A new approach to the asymmetric synthesis of .alpha.-hydrazino and .alpha.-amino acid derivatives von Evans, David A, Britton, Thomas C, Dorow, Roberta L, Dellaria, Joseph F

Volltext

Electrophilic azide transfer to chiral enolates. A general approach to the asymmetric synthesis of .alpha.-amino acids von Evans, David A, Britton, Thomas C

Volltext

SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)- N-(3-pyridinylmethyl)ethanesulfonamide von Barda, David A., Wang, Zhao-Qing, Britton, Thomas C., Henry, Steven S., Jagdmann, G.Erik, Coleman, Darrell S., Johnson, Michael P., Andis, Sherri L., Schoepp, Darryle D.

Volltext

Synthesis and Evaluation of a Series of Novel 2-[(4-Chlorophenoxy)methyl]- benzimidazoles as Selective Neuropeptide Y Y1 Receptor Antagonists von Zarrinmayeh, Hamideh, Nunes, Anne M, Ornstein, Paul L, Zimmerman, Dennis M, Arnold, M. Brian, Schober, Douglas A, Gackenheimer, Susan L, Bruns, Robert F, Hipskind, Philip A, Britton, Thomas C, Cantrell, Buddy E, Gehlert, Donald R

Volltext

Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists von Zarrinmayeh, Hamideh, Zimmerman, Dennis M., Cantrell, Buddy E., Schober, Douglas A., Bruns, Robert E., Gackenheimer, Susan L., Ornstein, Paul L., Hipskind, Philip A., Britton, Thomas C., Gehlert, Donald R.

Volltext

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor : Synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl... von JOHNSON, Michael P, BAEZ, Melvyn, JAGDMANN, G. Erik, BRITTON, Thomas C, LARGE, Thomas H, CALLAGARO, David O, TIZZANO, Joseph P, MONN, James A, SCHOEPP, Darryle D

Volltext

Metabotropic Glutamate 2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice von Benvenga, Mark J, Chaney, Stephen F, Baez, Melvyn, Britton, Thomas C, Hornback, William J, Monn, James A, Marek, Gerard J

Volltext

Clinical use of the magnetic stimulator in the investigation of peripheral conduction time von Britton, Thomas C., Meyer, Bernd-Ulrich, Herdmann, Jörg, Benecke, Reiner

Volltext

Structure-activity relationships of a series of benzothiophene-derived NPY Y1 antagonists: Optimization of the C-2 side chain von Britton, Thomas C., Spinazze, Patrick G., Hipskind, Philip A., Zimmerman, Dennis M., Zarrinmayeh, Hamideh, Schober, Douglas A., Gehlert, Donald R., Bruns, Robert F.

Volltext

Intelligent Contingency Management for Urban Air Mobility von Gregory, Irene M., Campbell, Newton H., Neogi, Natasha A., Holbrook, Jon B., Grauer, Jared A., Bacon, Barton J., Murphy, Patrick C., Moerder, Daniel D., Simmons, Benjamin M., Acheson, Michael J., Britton, Thomas C., Cook, Jacob W.

Volltext

Degradation Chemistry of Gemcitabine Hydrochloride, a New Antitumor Agent von Anliker, Sally L., McClure, Michael S., Britton, Thomas C., Stephan, Erwin A., Maple, Steven R., Cooke, Gary G.

Volltext