Crystal Structure of Human Cytochrome P450 2D6 von Rowland, Paul, Blaney, Frank E., Smyth, Martin G., Jones, Jo J., Leydon, Vaughan R., Oxbrow, Amanda K., Lewis, Ceri J., Tennant, Mike G., Modi, Sandeep, Eggleston, Drake S., Chenery, Richard J., Bridges, Angela M.

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A Model of the Membrane-bound Cytochrome b5-Cytochrome P450 Complex from NMR and Mutagenesis Data von Ahuja, Shivani, Jahr, Nicole, Im, Sang-Choul, Vivekanandan, Subramanian, Popovych, Nataliya, Le Clair, Stéphanie V., Huang, Rui, Soong, Ronald, Xu, Jiadi, Yamamoto, Kazutoshi, Nanga, Ravi P., Bridges, Angela, Waskell, Lucy, Ramamoorthy, Ayyalusamy

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Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors von Demont, Emmanuel H., Chung, Chun-wa, Furze, Rebecca C., Grandi, Paola, Michon, Anne-Marie, Wellaway, Chris, Barrett, Nathalie, Bridges, Angela M., Craggs, Peter D., Diallo, Hawa, Dixon, David P., Douault, Clement, Emmons, Amanda J., Jones, Emma J., Karamshi, Bhumika V., Locke, Kelly, Mitchell, Darren J., Mouzon, Bernadette H., Prinjha, Rab K., Roberts, Andy D., Sheppard, Robert J., Watson, Robert J., Bamborough, Paul

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MrgX2 is a promiscuous receptor for basic peptides causing mast cell pseudo‐allergic and anaphylactoid reactions von Grimes, Jak, Desai, Sapna, Charter, Neil W., Lodge, James, Moita Santos, Rita, Isidro‐Llobet, Albert, Mason, Andrew M., Wu, Zining, Wolfe, Lawrence A., Anantharaman, Lakshmi, Green, Andrew, Bridges, Angela M., Dalmas Wilk, Deidre A., Brown, Andrew J.

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A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification von Bamborough, Paul, Chung, Chun-wa, Demont, Emmanuel H, Bridges, Angela M, Craggs, Peter D, Dixon, David P, Francis, Peter, Furze, Rebecca C, Grandi, Paola, Jones, Emma J, Karamshi, Bhumika, Locke, Kelly, Lucas, Simon C. C, Michon, Anne-Marie, Mitchell, Darren J, Pogány, Peter, Prinjha, Rab K, Rau, Christina, Roa, Ana Maria, Roberts, Andrew D, Sheppard, Robert J, Watson, Robert J

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Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients von Lekova, Eleonora, Zelek, Wioleta M., Gower, David, Spitzfaden, Claus, Osuch, Isabelle H., John-Morris, Elen, Stach, Lasse, Gormley, Darren, Sanderson, Andrew, Bridges, Angela, Wear, Elizabeth R., Petit-Frere, Sebastien, Burden, Michael N., Priest, Richard, Wattam, Trevor, Kitchen, Semra J., Feeney, Maria, Davis, Susannah, Morgan, B. Paul, Nichols, Eva-Maria

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Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses von Grimley, Rachel, Polyakova, Oxana, Vamathevan, Jessica, McKenary, Joanne, Hayes, Brian, Patel, Champa, Smith, Janet, Bridges, Angela, Fosberry, Andrew, Bhardwaja, Anshu, Mouzon, Bernadette, Chung, Chun-Wa, Barrett, Nathalie, Richmond, Nicola, Modha, Sundip, Solari, Roberto

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CCR2:  Characterization of the Antagonist Binding Site from a Combined Receptor Modeling/Mutagenesis Approach von Berkhout, Theo A, Blaney, Frank E, Bridges, Angela M, Cooper, David G, Forbes, Ian T, Gribble, Andrew D, Groot, Pieter H. E, Hardy, Adam, Ife, Robert J, Kaur, Rejbinder, Moores, Kitty E, Shillito, Helen, Willetts, Jennifer, Witherington, Jason

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Discovery of GSK2795039, a Novel Small Molecule NADPH Oxidase 2 Inhibitor von Hirano, Kazufumi, Chen, Woei Shin, Chueng, Adeline L W, Dunne, Angela A, Seredenina, Tamara, Filippova, Aleksandra, Ramachandran, Sumitra, Bridges, Angela, Chaudry, Laiq, Pettman, Gary, Allan, Craig, Duncan, Sarah, Lee, Kiew Ching, Lim, Jean, Ma, May Thu, Ong, Agnes B, Ye, Nicole Y, Nasir, Shabina, Mulyanidewi, Sri, Aw, Chiu Cheong, Oon, Pamela P, Liao, Shihua, Li, Dizheng, Johns, Douglas G, Miller, Neil D, Davies, Ceri H, Browne, Edward R, Matsuoka, Yasuji, Chen, Deborah W, Jaquet, Vincent, Rutter, A Richard

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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response von Kruidenier, Laurens, Chung, Chun-wa, Cheng, Zhongjun, Liddle, John, Che, KaHing, Joberty, Gerard, Bantscheff, Marcus, Bountra, Chas, Bridges, Angela, Diallo, Hawa, Eberhard, Dirk, Hutchinson, Sue, Jones, Emma, Katso, Roy, Leveridge, Melanie, Mander, Palwinder K., Mosley, Julie, Ramirez-Molina, Cesar, Rowland, Paul, Schofield, Christopher J., Sheppard, Robert J., Smith, Julia E., Swales, Catherine, Tanner, Robert, Thomas, Pamela, Tumber, Anthony, Drewes, Gerard, Oppermann, Udo, Patel, Dinshaw J., Lee, Kevin, Wilson, David M.

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Probing the binding of interleukin-23 to individual receptor components and the IL-23 heteromeric receptor complex in living cells using NanoBRET von Lay, Charles S., Bridges, Angela, Goulding, Joelle, Briddon, Stephen J., Soloviev, Zoja, Craggs, Peter D., Hill, Stephen J.

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Decorating Self-Assembled Peptide Cages with Proteins von Ross, James F, Bridges, Angela, Fletcher, Jordan M, Shoemark, Deborah, Alibhai, Dominic, Bray, Harriet E. V, Beesley, Joseph L, Dawson, William M, Hodgson, Lorna R, Mantell, Judith, Verkade, Paul, Edge, Colin M, Sessions, Richard B, Tew, David, Woolfson, Derek N

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GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice von Pearce, Andrew C., Bamford, Mark J., Barber, Ruth, Bridges, Angela, Convery, Maire A., Demetriou, Constantinos, Evans, Sian, Gobbetti, Thomas, Hirst, David J., Holmes, Duncan S., Hutchinson, Jonathan P., Jayne, Sandrine, Lezina, Larissa, McCabe, Michael T., Messenger, Cassie, Morley, Joanne, Musso, Melissa C., Scott-Stevens, Paul, Manso, Ana Sousa, Schofield, Jennifer, Slocombe, Tom, Somers, Don, Walker, Ann L., Wyce, Anastasia, Zhang, Xi-Ping, Wagner, Simon D.

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Potential of real-time measurement of GFP-fusion proteins von Jones, Jo J, Bridges, Angela M, Fosberry, Andrew P, Gardner, Sharmila, Lowers, Robert R, Newby, Rachel R, James, Philip J, Hall, Richard M, Jenkins, Owen

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Impact of high throughput technology on recombinant protein production von Jones, Jo J, Bridges, Angela M, Fosberry, Andrew P, Bullock, Jonathan, Hudson, Ian, Hall, Richard M, Jenkins, Owen, Cole, Jeffrey A

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Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures von Monteiro, Olivia, Chen, Changwei, Bingham, Ryan, Argyrou, Argyrides, Buxton, Rachel, Pancevac Jönsson, Christina, Jones, Emma, Bridges, Angela, Gatfield, Kelly, Krauß, Sybille, Lambert, Jeremy, Langston, Rosamund, Schweiger, Susann, Uings, Iain

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Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy von Li, Dianfan, Howe, Nicole, Dukkipati, Abhiram, Shah, Syed T. A, Bax, Benjamin D, Edge, Colin, Bridges, Angela, Hardwicke, Phil, Singh, Onkar M. P, Giblin, Ged, Pautsch, Alexander, Pfau, Roland, Schnapp, Gisela, Wang, Meitian, Olieric, Vincent, Caffrey, Martin

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5-Aryl-4-carboxamide-1,3-oxazoles: Potent and selective GSK-3 inhibitors von Gentile, Gabriella, Merlo, Giancarlo, Pozzan, Alfonso, Bernasconi, Giovanni, Bax, Benjamin, Bamborough, Paul, Bridges, Angela, Carter, Paul, Neu, Margarete, Yao, Gang, Brough, Caroline, Cutler, Geoffrey, Coffin, Aaron, Belyanskaya, Svetlana

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Demonstrating Enhanced Throughput of RapidFire Mass Spectrometry through Multiplexing Using the JmjD2d Demethylase as a Model System von Leveridge, Melanie, Buxton, Rachel, Argyrou, Argyrides, Francis, Peter, Leavens, Bill, West, Andy, Rees, Mike, Hardwicke, Philip, Bridges, Angela, Ratcliffe, Steven, Chung, Chun-wa

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Enabling Lead Discovery for Histone Lysine Demethylases by High-Throughput RapidFire Mass Spectrometry von Hutchinson, Sue E., Leveridge, Melanie V., Heathcote, Michelle L., Francis, Peter, Williams, Laura, Gee, Michelle, Munoz-Muriedas, Jordi, Leavens, Bill, Shillings, Anthony, Jones, Emma, Homes, Paul, Baddeley, Stuart, Chung, Chun-wa, Bridges, Angela, Argyrou, Argyrides

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