The future of myeloma precision medicine: integrating the compendium of known drug resistance mechanisms with emerging tumor profiling technologies von Harding, Taylor, Baughn, Linda, Kumar, Shaji, Van Ness, Brian

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Applications and limitations in translating genomics to clinical practice von Van Ness, Brian

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PIAS1 Promotes Lymphomagenesis through MYC Upregulation von Rabellino, Andrea, Melegari, Margherita, Tompkins, Van S., Chen, Weina, Van Ness, Brian G., Teruya-Feldstein, Julie, Conacci-Sorrell, Maralice, Janz, Siegfried, Scaglioni, Pier Paolo

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The polycomb group protein enhancer of zeste homolog 2 (EZH2) is an oncogene that influences myeloma cell growth and the mutant ras phenotype von Croonquist, Paula A, Van Ness, Brian

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secDrug: a pipeline to discover novel drug combinations to kill drug-resistant multiple myeloma cells using a greedy set cover algorithm and single-cell multi-omics von Kumar, Harish, Mazumder, Suman, Chakravarti, Sayak, Sharma, Neeraj, Mukherjee, Ujjal Kumar, Kumar, Shaji, Baughn, Linda B, Van Ness, Brian G, Mitra, Amit Kumar

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Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells von Thompson, Ravyn M, Dytfeld, Dominik, Reyes, Leticia, Robinson, Reeder M, Smith, Brittany, Manevich, Yefim, Jakubowiak, Andrzej, Komarnicki, Mieczyslaw, Przybylowicz-Chalecka, Anna, Szczepaniak, Tomasz, Mitra, Amit K, Van Ness, Brian G, Luczak, Magdalena, Dolloff, Nathan G

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Returning a Research Participant's Genomic Results to Relatives: Perspectives from Managers of Two Distinct Research Biobanks von Petersen, Gloria M., Ness, Brian Van

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In vitro and ex vivo gene expression profiling reveals differential kinetic response of HSPs and UPR genes is associated with PI resistance in multiple myeloma von Mitra, Amit Kumar, Kumar, Harish, Ramakrishnan, Vijay, Chen, Li, Baughn, Linda, Kumar, Shaji, Rajkumar, S. Vincent, Van Ness, Brian G.

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Antitumor Activity of the Investigational Proteasome Inhibitor MLN9708 in Mouse Models of B-cell and Plasma Cell Malignancies von LEE, Edmund C, FITZGERALD, Michael, PICKARD, Michael, ZHI LI, TAYBER, Olga, PING LI, HALES, Paul, CARSILLO, Mary, NEPPALLI, Vishala T, BERGER, Allison J, KUPPERMAN, Erik, MANFREDI, Mark, BANNERMAN, Bret, BOLEN, Joseph B, NESS, Brian Van, JANZ, Siegfried, DONELAN, Jill, BANO, Kristen, TERKELSEN, Jennifer, BRADLEY, Daniel P, SUBAKAN, Ozlem, SILVA, Matthew D, LIU, Ray

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Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model von Stessman, Holly A F, Baughn, Linda B, Sarver, Aaron, Xia, Tian, Deshpande, Raamesh, Mansoor, Aatif, Walsh, Susan A, Sunderland, John J, Dolloff, Nathan G, Linden, Michael A, Zhan, Fenghuang, Janz, Siegfried, Myers, Chad L, Van Ness, Brian G

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Targeted overexpression of an activated N- ras gene results in B-cell and plasma cell lymphoproliferation and cooperates with c- myc to induce fatal B-cell neoplasia von Linden, Michael A, Kirchhof, Nicole, Carlson, Cathy S, Van Ness, Brian G

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Single-Cell Proteomics and Tumor RNAseq Identify Novel Pathways Associated With Clofazimine Sensitivity in PI- and IMiD- Resistant Myeloma, and Putative Stem-Like Cells von Kumar, Harish, Mazumder, Suman, Sharma, Neeraj, Chakravarti, Sayak, Long, Mark D, Meurice, Nathalie, Petit, Joachim, Liu, Song, Chesi, Marta, Sanyal, Sabyasachi, Stewart, A Keith, Kumar, Shaji, Bergsagel, Leif, Rajkumar, S Vincent, Baughn, Linda B, Van Ness, Brian G, Mitra, Amit Kumar

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A de novo splice site mutation in EHMT 1 resulting in Kleefstra syndrome with pharmacogenomics screening and behavior therapy for regressive behaviors von Mitra, Amit Kumar, Dodge, Jessica, Van Ness, Jody, Sokeye, Israel, Van Ness, Brian

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Understanding Drug Sensitivity and Tackling Resistance in Cancer von Tyner, Jeffrey W, Haderk, Franziska, Kumaraswamy, Anbarasu, Baughn, Linda B, Van Ness, Brian, Liu, Song, Marathe, Himangi, Alumkal, Joshi J, Bivona, Trever G, Chan, Keith Syson, Druker, Brian J, Hutson, Alan D, Nelson, Peter S, Sawyers, Charles L, Willey, Christopher D

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Discovering genetic interactions bridging pathways in genome-wide association studies von Fang, Gang, Wang, Wen, Paunic, Vanja, Heydari, Hamed, Costanzo, Michael, Liu, Xiaoye, Liu, Xiaotong, VanderSluis, Benjamin, Oately, Benjamin, Steinbach, Michael, Van Ness, Brian, Schadt, Eric E., Pankratz, Nathan D., Boone, Charles, Kumar, Vipin, Myers, Chad L.

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Managing incidental findings and research results in genomic research involving biobanks and archived data sets von Wolf, Susan M., Crock, Brittney N., Van Ness, Brian, Lawrenz, Frances, Kahn, Jeffrey P., Beskow, Laura M., Cho, Mildred K., Christman, Michael F., Green, Robert C., Hall, Ralph, Illes, Judy, Keane, Moira, Knoppers, Bartha M., Koenig, Barbara A., Kohane, Isaac S., LeRoy, Bonnie, Maschke, Karen J., McGeveran, William, Ossorio, Pilar, Parker, Lisa S., Petersen, Gloria M., Richardson, Henry S., Scott, Joan A., Terry, Sharon F., Wilfond, Benjamin S., Wolf, Wendy A.

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Molecular signatures of multiple myeloma progression through single cell RNA-Seq von Jang, Jin Sung, Li, Ying, Mitra, Amit Kumar, Bi, Lintao, Abyzov, Alexej, van Wijnen, Andre J., Baughn, Linda B., Van Ness, Brian, Rajkumar, Vincent, Kumar, Shaji, Jen, Jin

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Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival von Van Ness, Brian, Ramos, Christine, Haznadar, Majda, Hoering, Antje, Haessler, Jeff, Crowley, John, Jacobus, Susanna, Oken, Martin, Rajkumar, Vincent, Greipp, Philip, Barlogie, Bart, Durie, Brian, Katz, Michael, Atluri, Gowtham, Fang, Gang, Gupta, Rohit, Steinbach, Michael, Kumar, Vipin, Mushlin, Richard, Johnson, David, Morgan, Gareth

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Genetic Factors Underlying the Risk of Thalidomide-Related Neuropathy in Patients With Multiple Myeloma von JOHNSON, David C, CORTHALS, Sophie L, VAN NESS, Brian, CHILD, J. Anthony, SONNEVELD, Pieter, MORGAN, Gareth J, WALKER, Brian A, ROSS, Fiona M, GREGORY, Walter M, DICKENS, Nicholas J, LOKHORST, Henk M, GOLDSCHMIDT, Hartmut, DAVIES, Faith E, DURIE, Brian G. M

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Managing Incidental Findings in Human Subjects Research: Analysis and Recommendations von Wolf, Susan M., Lawrenz, Frances P., Nelson, Charles A., Kahn, Jeffrey P., Cho, Mildred K., Clayton, Ellen Wright, Fletcher, Joel G., Georgieff, Michael K., Hammerschmidt, Dale, Hudson, Kathy, Illes, Judy, Kapur, Vivek, Keane, Moira A., Koenig, Barbara A., LeRoy, Bonnie S., McFarland, Elizabeth G., Paradise, Jordan, Parker, Lisa S., Terry, Sharon F., Van Ness, Brian, Wilfond, Benjamin S.

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