Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase von Smith, Blake E., Wang, Stephen L., Jaime-Figueroa, Saul, Harbin, Alicia, Wang, Jing, Hamman, Brian D., Crews, Craig M.

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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1 von Crew, Andrew P, Raina, Kanak, Dong, Hanqing, Qian, Yimin, Wang, Jing, Vigil, Dominico, Serebrenik, Yevgeniy V, Hamman, Brian D, Morgan, Alicia, Ferraro, Caterina, Siu, Kam, Neklesa, Taavi K, Winkler, James D, Coleman, Kevin G, Crews, Craig M

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Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers von Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D., Rose, Christopher M., Cheung, Tommy K., Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S., Berlin, Michael, Yauch, Robert L.

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Genetic deletion of Mst1 alters T cell function and protects against autoimmunity von Salojin, Konstantin V, Hamman, Brian D, Chang, Wei Chun, Jhaver, Kanchan G, Al-Shami, Amin, Crisostomo, Jeannette, Wilkins, Carrie, Digeorge-Foushee, Ann Marie, Allen, Jason, Patel, Nita, Gopinathan, Suma, Zhou, Julia, Nouraldeen, Amr, Jessop, Theodore C, Bagdanoff, Jeffrey T, Augeri, David J, Read, Robert, Vogel, Peter, Swaffield, Jonathan, Wilson, Alan, Platt, Kenneth A, Carson, Kenneth G, Main, Alan, Zambrowicz, Brian P, Oravecz, Tamas

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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead von Bondeson, Daniel P., Smith, Blake E., Burslem, George M., Buhimschi, Alexandru D., Hines, John, Jaime-Figueroa, Saul, Wang, Jing, Hamman, Brian D., Ishchenko, Alexey, Crews, Craig M.

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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma von Harrison, Bryce A, Almstead, Zheng Y, Burgoon, Hugh, Gardyan, Michael, Goodwin, Nicole C, Healy, Jason, Liu, Ying, Mabon, Ross, Marinelli, Brett, Samala, Lakshman, Zhang, Yulian, Stouch, Terry R, Whitlock, N. Andrew, Gopinathan, Suma, McKnight, Beth, Wang, Shuli, Patel, Nita, Wilson, Alan G. E, Hamman, Brian D, Rice, Dennis S, Rawlins, David B

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BiP Maintains the Permeability Barrier of the ER Membrane by Sealing the Lumenal End of the Translocon Pore before and Early in Translocation von Hamman, Brian D, Hendershot, Linda M, Johnson, Arthur E

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Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma von Harrison, Bryce A, Whitlock, N. Andrew, Voronkov, Michael V, Almstead, Zheng Y, Gu, Kun-jian, Mabon, Ross, Gardyan, Michael, Hamman, Brian D, Allen, Jason, Gopinathan, Suma, McKnight, Beth, Crist, Mike, Zhang, Yulian, Liu, Ying, Courtney, Lawrence F, Key, Billie, Zhou, Julia, Patel, Nita, Yates, Phil W, Liu, Qingyun, Wilson, Alan G. E, Kimball, S. David, Crosson, Craig E, Rice, Dennis S, Rawlins, David B

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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models von Berlin, Michael, Cantley, Jennifer, Bookbinder, Mark, Bortolon, Elizabeth, Broccatelli, Fabio, Cadelina, Greg, Chan, Emily W., Chen, Huifen, Chen, Xin, Cheng, Yunxing, Cheung, Tommy K., Davenport, Kim, DiNicola, Dean, Gordon, Debbie, Hamman, Brian D., Harbin, Alicia, Haskell, Roy, He, Mingtao, Hole, Alison J., Januario, Thomas, Kerry, Philip S., Koenig, Stefan G., Li, Limei, Merchant, Mark, Pérez-Dorado, Inmaculada, Pizzano, Jennifer, Quinn, Connor, Rose, Christopher M., Rousseau, Emma, Soto, Leofal, Staben, Leanna R., Sun, Hongming, Tian, Qingping, Wang, Jing, Wang, Weifeng, Ye, Crystal S., Ye, Xiaofen, Zhang, Penghong, Zhou, Yuhui, Yauch, Robert, Dragovich, Peter S.

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Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2‑Associated Kinase 1 (AAK1) Inhibitors for the Treatmen... von Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C.M. Vijaya, Brown, Jeffrey M, Bristow, Linda J, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel, Kiefer, Susan E, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Easton, Amy, Lippy, Jonathan S, Surti, Neha, Pattipati, Sreenivasulu N, Dokania, Manoj, Elavazhagan, Saravanan, Dandapani, Kumaran, Hamman, Brian D, Allen, Jason, Kostich, Walter, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D

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A FRET-based assay platform for ultra-high density drug screening of protein kinases and phosphatases von Rodems, Steven M, Hamman, Brian D, Lin, Christina, Zhao, Jane, Shah, Sundeep, Heidary, David, Makings, Lew, Stack, Jeffrey H, Pollok, Brian A

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Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2‑Associated Kinase 1 Inhibitors von Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C. M. Vijaya, Manepalli, Raju K. V. L. P, Sarvasiddhi, Sarat Kumar, Honkhambe, Swarnamba, Patankar, Vidya, Dasgupta, Bireshwar, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel M, Ghosh, Kaushik, Pokross, Matthew, Kiefer, Susan E, Brown, Jeffrey M, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Lippy, Jonathan S, Surti, Neha, Hamman, Brian D, Allen, Jason, Kostich, Walter A, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D

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Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation von Goodwin, Nicole C, Cianchetta, Giovanni, Burgoon, Hugh A, Healy, Jason, Mabon, Ross, Strobel, Eric D, Allen, Jason, Wang, Shuli, Hamman, Brian D, Rawlins, David B

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Profound Obesity Secondary to Hyperphagia in Mice Lacking Kinase Suppressor of Ras 2 von Revelli, Jean‐Pierre, Smith, Deon, Allen, Jason, Jeter‐Jones, Sabrina, Shadoan, Melanie K., Desai, Urvi, Schneider, Matthias, Sligtenhorst, Isaac, Kirkpatrick, Laura, Platt, Kenneth A., Suwanichkul, Adisak, Savelieva, Katerina, Gerhardt, Brenda, Mitchell, Jay, Syrewicz, James, Zambrowicz, Brian, Hamman, Brian D., Vogel, Peter, Powell, David R.

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Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming Toxin Clostridium perfringens Perfringolysin O:  An α-Helical to β-Sheet Transition Identified by F... von Shepard, Laura A, Heuck, Alejandro P, Hamman, Brian D, Rossjohn, Jamie, Parker, Michael W, Ryan, Kathleen R, Johnson, Arthur E, Tweten, Rodney K

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A homogeneous G protein-coupled receptor ligand binding assay based on time-resolved fluorescence resonance energy transfer von Hu, Liaoyuan A, Zhou, Tian, Hamman, Brian D, Liu, Qingyun

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A High-Throughput Screen for Receptor Protein Tyrosine Phosphatase–γ Selective Inhibitors von Appiah, Kingsley K., Kostich, Walter A., Gerritz, Samuel W., Huang, Yanling, Hamman, Brian D., Allen, Jason, Zhang, Wandong, Lanthorn, Thomas H., Albright, Charles F., Westphal, Ryan, Banks, Martyn N., O’Connell, Jonathan C.

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Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain von Kostich, Walter, Hamman, Brian D., Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V., Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K., Gulianello, Michael, Molski, Ted, Brown, Jeffrey M., Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O’Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H., Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E., Lentz, Kimberley A., Santone, Kenneth S., Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K., Nara, Susheel J., Dzierba, Carolyn, Bronson, Joanne, Macor, John E., Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M., Zambrowicz, Brian, Albright, Charles F.

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Tetramethylrhodamine Dimer Formation as a Spectroscopic Probe of the Conformation of Escherichia coli Ribosomal Protein L7/L12 Dimers (∗) von Hamman, Brian D., Oleinikov, Andrew V., Jokhadze, George G., Bochkariov, Dmitry E., Traut, Robert R., Jameson, David M.

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Dimer/Monomer Equilibrium and Domain Separations of Escherichia coli Ribosomal Protein L7/L12 von Hamman, Brian D, Oleinikov, Andrew V, Jokhadze, George G, Traut, Robert R, Jameson, David M

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