A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects von Talukdar, Saswata, Zhou, Yingjiang, Li, Dongmei, Rossulek, Michelle, Dong, Jennifer, Somayaji, Veena, Weng, Yan, Clark, Ronald, Lanba, Adhiraj, Owen, Bryn M., Brenner, Martin B., Trimmer, Jeffrey K., Gropp, Kathryn E., Chabot, Jeffrey R., Erion, Derek M., Rolph, Timothy P., Goodwin, Bryan, Calle, Roberto A.

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FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues von Schlein, Christian, Talukdar, Saswata, Heine, Markus, Fischer, Alexander W., Krott, Lucia M., Nilsson, Stefan K., Brenner, Martin B., Heeren, Joerg, Scheja, Ludger

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Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase von Talukdar, Saswata, Oh, Da Young, Bandyopadhyay, Gautam, Li, Dongmei, Xu, Jianfeng, McNelis, Joanne, Lu, Min, Li, Pingping, Yan, Qingyun, Zhu, Yimin, Ofrecio, Jachelle, Lin, Michael, Brenner, Martin B, Olefsky, Jerrold M

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Pharmacokinetics (PK), pharmacodynamics (PD) and integrated PK/PD modeling of a novel long acting FGF21 clinical candidate PF-05231023 in diet-induced obese and leptin-deficient ob... von Weng, Yan, Chabot, Jeffrey R, Bernardo, Barbara, Yan, Qingyun, Zhu, Yimin, Brenner, Martin B, Vage, Chandra, Logan, Alison, Calle, Roberto, Talukdar, Saswata

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Fibroblast growth factor 21 improves insulin sensitivity and synergizes with insulin in human adipose stem cell-derived (hASC) adipocytes von Lee, Darwin V, Li, Dongmei, Yan, Qingyun, Zhu, Yimin, Goodwin, Bryan, Calle, Roberto, Brenner, Martin B, Talukdar, Saswata

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Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets von Sloop, Kyle W, Willard, Francis S, Brenner, Martin B, Ficorilli, James, Valasek, Kathleen, Showalter, Aaron D, Farb, Thomas B, Cao, Julia X C, Cox, Amy L, Michael, M Dodson, Gutierrez Sanfeliciano, Sonia Maria, Tebbe, Mark J, Coghlan, Michael J

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A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function von Efanov, Alexander M, Barrett, David G, Brenner, Martin B, Briggs, Stephen L, Delaunois, Annie, Durbin, Jim D, Giese, Ulrich, Guo, Haihong, Radloff, Mark, Gil, Gema Sanz, Sewing, Sabine, Wang, Yong, Weichert, Andreas, Zaliani, Andrea, Gromada, Jesper

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Novel pancreatic endocrine maturation pathways identified by genomic profiling and causal reasoning von Gutteridge, Alex, Rukstalis, J Michael, Ziemek, Daniel, Tié, Mark, Ji, Lin, Ramos-Zayas, Rebeca, Nardone, Nancy A, Norquay, Lisa D, Brenner, Martin B, Tang, Kim, McNeish, John D, Rowntree, Rebecca K

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Activation of Liver X Receptors and Retinoid X Receptors Induces Growth Arrest and Apoptosis in Insulin-Secreting Cells von Wente, Wolf, Brenner, Martin B, Zitzer, Heike, Gromada, Jesper, Efanov, Alexander M

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Ectonucleotidase NTPDase3 is abundant in pancreatic β-cells and regulates glucose-induced insulin secretion von Syed, Samreen K, Kauffman, Audra L, Beavers, Lisa S, Alston, James T, Farb, Thomas B, Ficorilli, James, Marcelo, Marialuisa C, Brenner, Martin B, Bokvist, Krister, Barrett, David G, Efanov, Alexander M

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Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors von Sloop, Kyle W, Cao, Julia Xiao-Chun, Siesky, Angela M, Zhang, Hong Yan, Bodenmiller, Diane M, Cox, Amy L, Jacobs, Steven J, Moyers, Julie S, Owens, Rebecca A, Showalter, Aaron D, Brenner, Martin B, Raap, Achim, Gromada, Jesper, Berridge, Brian R, Monteith, David K B, Porksen, Niels, McKay, Robert A, Monia, Brett P, Bhanot, Sanjay, Watts, Lynnetta M, Michael, M Dodson

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Sterol Regulatory Element-Binding Protein 1 Mediates Liver X Receptor-β-Induced Increases in Insulin Secretion and Insulin Messenger Ribonucleic Acid Levels von Zitzer, Heike, Wente, Wolf, Brenner, Martin B, Sewing, Sabine, Buschard, Karsten, Gromada, Jesper, Efanov, Alexander M

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Identification of Tetrahydropyrido[4,3‑d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists von Piotrowski, David W, Futatsugi, Kentaro, Warmus, Joseph S, Orr, Suvi T. M, Freeman-Cook, Kevin D, Londregan, Allyn T, Wei, Liuqing, Jennings, Sandra M, Herr, Michael, Coffey, Steven B, Jiao, Wenhua, Storer, Gregory, Hepworth, David, Wang, Jian, Lavergne, Sophie Y, Chin, Janice E, Hadcock, John R, Brenner, Martin B, Wolford, Angela C, Janssen, Ann M, Roush, Nicole S, Buxton, Joanne, Hinchey, Terri, Kalgutkar, Amit S, Sharma, Raman, Flynn, Declan A

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Optimization of triazole-based TGR5 agonists towards orally available agents von Futatsugi, Kentaro, Bahnck, Kevin B., Brenner, Martin B., Buxton, Joanne, Chin, Janice E., Coffey, Steven B., Dubins, Jeffrey, Flynn, Declan, Gautreau, Denise, Guzman-Perez, Angel, Hadcock, John R., Hepworth, David, Herr, Michael, Hinchey, Terri, Janssen, Ann M., Jennings, Sandra M., Jiao, Wenhua, Lavergne, Sophie Y., Li, Bryan, Li, Mei, Munchhof, Michael J., Orr, Suvi T. M., Piotrowski, David W., Roush, Nicole S., Sammons, Matthew, Stevens, Benjamin D., Storer, Gregory, Wang, Jian, Warmus, Joseph S., Wei, Liuqing, Wolford, Angela C.

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Hepatic and glucagon-like peptide-1–mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors von Sloop, Kyle W., Cao, Julia Xiao-Chun, Siesky, Angela M., Zhang, Hong Yan, Bodenmiller, Diane M., Cox, Amy L., Jacobs, Steven J., Moyers, Julie S., Owens, Rebecca A., Showalter, Aaron D., Brenner, Martin B., Raap, Achim, Gromada, Jesper, Berridge, Brian R., Monteith, David K. B., Porksen, Niels, McKay, Robert A., Monia, Brett P., Bhanot, Sanjay, Watts, Lynnetta M., Michael, M. Dodson

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A buffer temperature controlled perifusion system to study temperature dependence and kinetics of insulin secretion in MIN6 pseudoislets von Brenner, Martin B., Mest, Hans-Juergen

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Pharmacokinetics and Integrated PK/PD Modeling of a Novel Long Acting FGF21 Clinical Candidate PF-05231023 in Diet-Induced Obese and Leptin-Deficient Obese Mice von Weng, Yan, Chabot, Jeffrey R, Bernardo, Barbara, Yan, Qingyun, Zhu, Yimin, Brenner, Martin B, Vage, Chandra, Logan, Alison, Calle, Roberto, Talukdar, Saswata

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Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived von Lee, Darwin V, Li, Dongmei, Yan, Qingyun, Zhu, Yimin, Goodwin, Bryan, Calle, Roberto, Brenner, Martin B, Talukdar, Saswata

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Ectonucleotidase NTPDase3 is abundant in pancreatic [Beta]-cells and regulates glucose-induced insulin secretion von Syed, Samreen K, Kauffman, Audra L, Beavers, Lisa S, Alston, James T, Farb, Thomas B, Ficorilli, James, Marcelo, Marialuisa C, Brenner, Martin B, Bokvist, Krister, Barrett, David G, Efanov, Alexander M

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Neutrophils mediate insulin resistance in high fat diet fed mice via secreted elastase von Talukdar, Saswata, Oh, Da Young, Bandyopadhyay, Gautam, Li, Dongmei, Xu, Jianfeng, McNelis, Joanne, Lu, Min, Li, Pingping, Yan, Qingyun, Zhu, Yimin, Ofrecio, Jachelle, Lin, Michael, Brenner, Martin B, Olefsky, Jerrold M

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