Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane von Frank, Nils, Nugent, Jeremy, Shire, Bethany R., Pickford, Helena D., Rabe, Patrick, Sterling, Alistair J., Zarganes-Tzitzikas, Tryfon, Grimes, Thomas, Thompson, Amber L., Smith, Russell C., Schofield, Christopher J., Brennan, Paul E., Duarte, Fernanda, Anderson, Edward A.

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TargetDB: A target information aggregation tool and tractability predictor von De Cesco, Stephane, Davis, John B., Brennan, Paul E.

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Recent Progress in Histone Demethylase Inhibitors von McAllister, Tom E, England, Katherine S, Hopkinson, Richard J, Brennan, Paul E, Kawamura, Akane, Schofield, Christopher J

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RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain von Picaud, Sarah, Wells, Christopher, Felletar, Ildiko, Brotherton, Deborah, Martin, Sarah, Savitsky, Pavel, Diez-Dacal, Beatriz, Philpott, Martin, Bountra, Chas, Lingard, Hannah, Fedorov, Oleg, Müller, Susanne, Brennan, Paul E., Knapp, Stefan, Filippakopoulos, Panagis

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CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses von Hammitzsch, Ariane, Tallant, Cynthia, Fedorov, Oleg, O’Mahony, Alison, Brennan, Paul E., Hay, Duncan A., Martinez, Fernando O., Al-Mossawi, M. Hussein, de Wit, Jelle, Vecellio, Matteo, Wells, Christopher, Wordsworth, Paul, Müller, Susanne, Knapp, Stefan, Bowness, Paul

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The Chemical Probes Portal - 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research von Sanfelice, Domenico, Antolin, Albert A, Crisp, Alisa, Chen, Yi, Bellenie, Benjamin, Brennan, Paul E, Edwards, Aled, Müller, Susanne, Al-Lazikani, Bissan, Workman, Paul

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The X-linked histone demethylases KDM5C and KDM6A as regulators of T cell-driven autoimmunity in the central nervous system von Fazazi, Mohamed Reda, Ruda, Gian Filippo, Brennan, Paul E., Rangachari, Manu

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A chemical toolbox for the study of bromodomains and epigenetic signaling von Wu, Qin, Heidenreich, David, Zhou, Stanley, Ackloo, Suzanne, Krämer, Andreas, Nakka, Kiran, Lima-Fernandes, Evelyne, Deblois, Genevieve, Duan, Shili, Vellanki, Ravi N., Li, Fengling, Vedadi, Masoud, Dilworth, Jeffrey, Lupien, Mathieu, Brennan, Paul E., Arrowsmith, Cheryl H., Müller, Susanne, Fedorov, Oleg, Filippakopoulos, Panagis, Knapp, Stefan

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Highly selective inhibition of histone demethylases by de novo macrocyclic peptides von Kawamura, Akane, Münzel, Martin, Kojima, Tatsuya, Yapp, Clarence, Bhushan, Bhaskar, Goto, Yuki, Tumber, Anthony, Katoh, Takayuki, King, Oliver N. F., Passioura, Toby, Walport, Louise J., Hatch, Stephanie B., Madden, Sarah, Müller, Susanne, Brennan, Paul E., Chowdhury, Rasheduzzaman, Hopkinson, Richard J., Suga, Hiroaki, Schofield, Christopher J.

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Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains von Hay, Duncan A, Fedorov, Oleg, Martin, Sarah, Singleton, Dean C, Tallant, Cynthia, Wells, Christopher, Picaud, Sarah, Philpott, Martin, Monteiro, Octovia P, Rogers, Catherine M, Conway, Stuart J, Rooney, Timothy P. C, Tumber, Anthony, Yapp, Clarence, Filippakopoulos, Panagis, Bunnage, Mark E, Müller, Susanne, Knapp, Stefan, Schofield, Christopher J, Brennan, Paul E

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Structural analysis of human KDM5B guides histone demethylase inhibitor development von Johansson, Catrine, Velupillai, Srikannathasan, Tumber, Anthony, Szykowska, Aleksandra, Hookway, Edward S, Nowak, Radoslaw P, Strain-Damerell, Claire, Gileadi, Carina, Philpott, Martin, Burgess-Brown, Nicola, Wu, Na, Kopec, Jola, Nuzzi, Andrea, Steuber, Holger, Egner, Ursula, Badock, Volker, Munro, Shonagh, LaThangue, Nicholas B, Westaway, Sue, Brown, Jack, Athanasou, Nick, Prinjha, Rab, Brennan, Paul E, Oppermann, Udo

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The structural basis of fatty acid elongation by the ELOVL elongases von Nie, Laiyin, Pascoa, Tomas C., Pike, Ashley C. W., Bushell, Simon R., Quigley, Andrew, Ruda, Gian Filippo, Chu, Amy, Cole, Victoria, Speedman, David, Moreira, Tiago, Shrestha, Leela, Mukhopadhyay, Shubhashish M. M., Burgess-Brown, Nicola A., Love, James D., Brennan, Paul E., Carpenter, Elisabeth P.

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Imaging articular cartilage in osteoarthritis using targeted peptide radiocontrast agents von Fowkes, Milan M, Das Neves Borges, Patricia, Cacho-Nerin, Fernando, Brennan, Paul E, Vincent, Tonia L, Lim, Ngee H

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Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF von Bennett, James, Fedorov, Oleg, Tallant, Cynthia, Monteiro, Octovia, Meier, Julia, Gamble, Vicky, Savitsky, Pavel, Nunez-Alonso, Graciela A, Haendler, Bernard, Rogers, Catherine, Brennan, Paul E, Müller, Susanne, Knapp, Stefan

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Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions von Hewings, David S, Rooney, Timothy P. C, Jennings, Laura E, Hay, Duncan A, Schofield, Christopher J, Brennan, Paul E, Knapp, Stefan, Conway, Stuart J

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Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells von Tumber, Anthony, Nuzzi, Andrea, Hookway, Edward S., Hatch, Stephanie B., Velupillai, Srikannathasan, Johansson, Catrine, Kawamura, Akane, Savitsky, Pavel, Yapp, Clarence, Szykowska, Aleksandra, Wu, Na, Bountra, Chas, Strain-Damerell, Claire, Burgess-Brown, Nicola A., Ruda, Gian Filippo, Fedorov, Oleg, Munro, Shonagh, England, Katherine S., Nowak, Radoslaw P., Schofield, Christopher J., La Thangue, Nicholas B., Pawlyn, Charlotte, Davies, Faith, Morgan, Gareth, Athanasou, Nick, Müller, Susanne, Oppermann, Udo, Brennan, Paul E.

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LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor von Clark, Peter G. K., Vieira, Lucas C. C., Tallant, Cynthia, Fedorov, Oleg, Singleton, Dean C., Rogers, Catherine M., Monteiro, Octovia P., Bennett, James M., Baronio, Roberta, Müller, Susanne, Daniels, Danette L., Méndez, Jacqui, Knapp, Stefan, Brennan, Paul E., Dixon, Darren J.

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Discovery of an MLLT1/3 YEATS Domain Chemical Probe von Moustakim, Moses, Christott, Thomas, Monteiro, Octovia P., Bennett, James, Giroud, Charline, Ward, Jennifer, Rogers, Catherine M., Smith, Paul, Panagakou, Ioanna, Díaz‐Sáez, Laura, Felce, Suet Ling, Gamble, Vicki, Gileadi, Carina, Halidi, Nadia, Heidenreich, David, Chaikuad, Apirat, Knapp, Stefan, Huber, Kilian V. M., Farnie, Gillian, Heer, Jag, Manevski, Nenad, Poda, Gennady, Al‐awar, Rima, Dixon, Darren J., Brennan, Paul E., Fedorov, Oleg

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Identification of a Chemical Probe for Bromo and Extra C‑Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit von Fish, Paul V, Filippakopoulos, Panagis, Bish, Gerwyn, Brennan, Paul E, Bunnage, Mark E, Cook, Andrew S, Federov, Oleg, Gerstenberger, Brian S, Jones, Hannah, Knapp, Stefan, Marsden, Brian, Nocka, Karl, Owen, Dafydd R, Philpott, Martin, Picaud, Sarah, Primiano, Michael J, Ralph, Michael J, Sciammetta, Nunzio, Trzupek, John D

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Exploring the role of water in molecular recognition: predicting protein ligandability using a combinatorial search of surface hydration sites von Vukovic, Sinisa, Brennan, Paul E, Huggins, David J

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