Riboswitches as Drug Targets for Antibiotics von Panchal, Vipul, Brenk, Ruth

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Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding von Khorsand, Fahimeh, Haug, Bengt Erik, Kursula, Inari, Reuter, Nathalie, Brenk, Ruth

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To Hit or Not to Hit, That Is the Question - Genome-wide Structure-Based Druggability Predictions for Pseudomonas aeruginosa Proteins von Sarkar, Aurijit, Brenk, Ruth

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Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases von Brenk, Ruth, Schipani, Alessandro, James, Daniel, Krasowski, Agata, Gilbert, Ian Hugh, Frearson, Julie, Wyatt, Paul Graham

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Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics [version 2; peer review: 2 approved] von Yadrykhins'ky, Vladyslav, Georgiou, Charis, Brenk, Ruth

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DrugPred: A Structure-Based Approach To Predict Protein Druggability Developed Using an Extensive Nonredundant Data Set von Krasowski, Agata, Muthas, Daniel, Sarkar, Aurijit, Schmitt, Stefan, Brenk, Ruth

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In silico identification and experimental validation of hits active against KPC-2 β-lactamase von Klein, Raphael, Linciano, Pasquale, Celenza, Giuseppe, Bellio, Pierangelo, Papaioannou, Sofia, Blazquez, Jesus, Cendron, Laura, Brenk, Ruth, Tondi, Donatella

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Identification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug design von Irsheid, Lina, Wehler, Thomas, Borek, Christoph, Kiefer, Werner, Brenk, Ruth, Ortiz-Soto, Maria Elena, Seibel, Jürgen, Schirmeister, Tanja

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On the hunt for metalloenzyme inhibitors: Investigating the presence of metal‐coordinating compounds in screening libraries and chemical spaces von Schuck, Bruna, Brenk, Ruth

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One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening von Mpamhanga, Chidochangu P, Spinks, Daniel, Tulloch, Lindsay B, Shanks, Emma J, Robinson, David A, Collie, Iain T, Fairlamb, Alan H, Wyatt, Paul G, Frearson, Julie A, Hunter, William N, Gilbert, Ian H, Brenk, Ruth

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De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments von Urich, Robert, Wishart, Grant, Kiczun, Michael, Richters, André, Tidten-Luksch, Naomi, Rauh, Daniel, Sherborne, Brad, Wyatt, Paul G, Brenk, Ruth

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RNA-binding is an ancient trait of the Annexin family von Patil, Sudarshan S, Panchal, Vipul, Røstbø, Trude, Romanyuk, Sofya, Hollås, Hanne, Brenk, Ruth, Grindheim, Ann Kari, Vedeler, Anni

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Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97 von Bothe, Sebastian, Hänzelmann, Petra, Böhler, Stephan, Kehrein, Josef, Zehe, Markus, Wiedemann, Christoph, Hellmich, Ute A., Brenk, Ruth, Schindelin, Hermann, Sotriffer, Christoph

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DrugPred_RNAA Tool for Structure-Based Druggability Predictions for RNA Binding Sites von Rekand, Illimar Hugo, Brenk, Ruth

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Targeting the Class A Carbapenemase GES-5 via Virtual Screening von Klein, Raphael, Cendron, Laura, Montanari, Martina, Bellio, Pierangelo, Celenza, Giuseppe, Maso, Lorenzo, Tondi, Donatella, Brenk, Ruth

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IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening von Tidten-Luksch, Naomi, Grimaldi, Raffaella, Torrie, Leah S, Frearson, Julie A, Hunter, William N, Brenk, Ruth

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Assessing small molecule conformational sampling methods in molecular docking von Xia, Qiancheng, Fu, Qiuyu, Shen, Cheng, Brenk, Ruth, Huang, Niu

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Introduction to the themed collection on 'Targeting RNA with small molecules' von Brenk, Ruth, Wu, Peng, Duca, Maria

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Ligand design for riboswitches, an emerging target class for novel antibiotics von Rekand, Illimar Hugo, Brenk, Ruth

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How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N‑Myristoyltransferases as a Model System von Kersten, Christian, Fleischer, Edmond, Kehrein, Josef, Borek, Christoph, Jaenicke, Elmar, Sotriffer, Christoph, Brenk, Ruth

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