Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases von Krajnc, Alen, Brem, Jürgen, Hinchliffe, Philip, Calvopiña, Karina, Panduwawala, Tharindi D, Lang, Pauline A, Kamps, Jos J. A. G, Tyrrell, Jonathan M, Widlake, Emma, Saward, Benjamin G, Walsh, Timothy R, Spencer, James, Schofield, Christopher J

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An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography von Butryn, Agata, Simon, Philipp S., Aller, Pierre, Hinchliffe, Philip, Massad, Ramzi N., Leen, Gabriel, Tooke, Catherine L., Bogacz, Isabel, Kim, In-Sik, Bhowmick, Asmit, Brewster, Aaron S., Devenish, Nicholas E., Brem, Jürgen, Kamps, Jos J. A. G., Lang, Pauline A., Rabe, Patrick, Axford, Danny, Beale, John H., Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L. S., Zhou, Tiankun, Owada, Shigeki, Tanaka, Rie, Tono, Kensuke, Evans, Gwyndaf, Owen, Robin L., Houle, Frances A., Sauter, Nicholas K., Schofield, Christopher J., Spencer, James, Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M.

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Will morphing boron-based inhibitors beat the β-lactamases? von Krajnc, Alen, Lang, Pauline A, Panduwawala, Tharindi D, Brem, Jürgen, Schofield, Christopher J

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Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates von Brem, Jürgen, Cain, Ricky, Cahill, Samuel, McDonough, Michael A., Clifton, Ian J., Jiménez-Castellanos, Juan-Carlos, Avison, Matthew B., Spencer, James, Fishwick, Colin W. G., Schofield, Christopher J.

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New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis von Lohans, Christopher T, Brem, Jürgen, Schofield, Christopher J

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In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors von Cain, Ricky, Brem, Jürgen, Zollman, David, McDonough, Michael A, Johnson, Rachel M, Spencer, James, Makena, Anne, Abboud, Martine I, Cahill, Samuel, Lee, Sook Y, McHugh, Peter J, Schofield, Christopher J, Fishwick, Colin W. G

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High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes von Newman, Hector, Krajnc, Alen, Bellini, Dom, Eyermann, Charles J, Boyle, Grant A, Paterson, Neil G, McAuley, Katherine E, Lesniak, Robert, Gangar, Mukesh, von Delft, Frank, Brem, Jürgen, Chibale, Kelly, Schofield, Christopher J, Dowson, Christopher G

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Molecular Basis of Class A β-Lactamase Inhibition by Relebactam von Tooke, Catherine L, Hinchliffe, Philip, Lang, Pauline A, Mulholland, Adrian J, Brem, Jürgen, Schofield, Christopher J, Spencer, James

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Optimized Synthesis of Indole Carboxylate Metallo-β-Lactamase Inhibitor EBL-3183 von Baran, Andrei, Kuzmins, Jevgenijs, Kuznecovs, Jevgenijs, Farley, Alistair J. M., Panduwawala, Tharindi, Parkova, Anete, Donets, Pavel A., Brem, Jürgen, Suna, Edgars, Schofield, Christopher J., Shubin, Kirill

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Mapping the Hydrophobic Substrate Binding Site of Phenylalanine Ammonia-Lyase from Petroselinum crispum von Nagy, Emma Z. A, Tork, Souad D, Lang, Pauline A, Filip, Alina, Irimie, Florin D, Poppe, László, Toşa, Monica I, Schofield, Christopher J, Brem, Jürgen, Paizs, Csaba, Bencze, László C

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Interaction of Avibactam with Class B Metallo-β-Lactamases von Abboud, Martine I, Damblon, Christian, Brem, Jürgen, Smargiasso, Nicolas, Mercuri, Paola, Gilbert, Bernard, Rydzik, Anna M, Claridge, Timothy D W, Schofield, Christopher J, Frère, Jean-Marie

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Assay Platform for Clinically Relevant Metallo-β-lactamases von van Berkel, Sander S, Brem, Jürgen, Rydzik, Anna M, Salimraj, Ramya, Cain, Ricky, Verma, Anil, Owens, Raymond J, Fishwick, Colin W. G, Spencer, James, Schofield, Christopher J

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Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1 von Hinchliffe, Philip, Yang, Qiu E., Portal, Edward, Young, Tom, Li, Hui, Tooke, Catherine L., Carvalho, Maria J., Paterson, Neil G., Brem, Jürgen, Niumsup, Pannika R., Tansawai, Uttapoln, Lei, Lei, Li, Mei, Shen, Zhangqi, Wang, Yang, Schofield, Christopher J., Mulholland, Adrian J, Shen, Jianzhong, Fey, Natalie, Walsh, Timothy R., Spencer, James

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How Clavulanic Acid Inhibits Serine β‐Lactamases von Lang, Pauline A., Munnik, Mariska, Oluwole, Abraham O., Claridge, Timothy D. W., Robinson, Carol V., Brem, Jürgen, Schofield, Christopher J.

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NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors von Li, Guo-Bo, Abboud, Martine I, Brem, Jürgen, Someya, Hidenori, Lohans, Christopher T, Yang, Sheng-Yong, Spencer, James, Wareham, David W, McDonough, Michael A, Schofield, Christopher J

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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors von Brem, Jürgen, Panduwawala, Tharindi, Hansen, Jon Ulf, Hewitt, Joanne, Liepins, Edgars, Donets, Pawel, Espina, Laura, Farley, Alistair J. M., Shubin, Kirill, Campillos, Gonzalo Gomez, Kiuru, Paula, Shishodia, Shifali, Krahn, Daniel, Leśniak, Robert K., Schmidt (Adrian), Juliane, Calvopiña, Karina, Turrientes, María-Carmen, Kavanagh, Madeline E., Lubriks, Dmitrijs, Hinchliffe, Philip, Langley, Gareth W., Aboklaish, Ali F., Eneroth, Anders, Backlund, Maria, Baran, Andrei G., Nielsen, Elisabet I., Speake, Michael, Kuka, Janis, Robinson, John, Grinberga, Solveiga, Robinson, Lindsay, McDonough, Michael A., Rydzik, Anna M., Leissing, Thomas M., Jimenez-Castellanos, Juan Carlos, Avison, Matthew B., Da Silva Pinto, Solange, Pannifer, Andrew D., Martjuga, Marina, Widlake, Emma, Priede, Martins, Hopkins Navratilova, Iva, Gniadkowski, Marek, Belfrage, Anna Karin, Brandt, Peter, Yli-Kauhaluoma, Jari, Bacque, Eric, Page, Malcolm G. P., Björkling, Fredrik, Tyrrell, Jonathan M., Spencer, James, Lang, Pauline A., Baranczewski, Pawel, Cantón, Rafael, McElroy, Stuart P., Jones, Philip S., Baquero, Fernando, Suna, Edgars, Morrison, Angus, Walsh, Timothy R., Schofield, Christopher J.

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Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM‑1 Carbapenemase von González, Mariano M, Kosmopoulou, Magda, Mojica, Maria F, Castillo, Valerie, Hinchliffe, Philip, Pettinati, Ilaria, Brem, Jürgen, Schofield, Christopher J, Mahler, Graciela, Bonomo, Robert A, Llarrull, Leticia I, Spencer, James, Vila, Alejandro J

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In vitro efficacy of imipenem-relebactam and cefepime-AAI101 against a global collection of ESBL-positive and carbapenemase-producing Enterobacteriaceae von Tselepis, Lucas, Langley, Gareth W., Aboklaish, Ali F., Widlake, Emma, Jackson, Dana E., Walsh, Timothy R., Schofield, Chris J., Brem, Jürgen, Tyrrell, Jonathan M.

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Profiling interactions of vaborbactam with metallo-β-lactamases von Langley, Gareth W., Cain, Ricky, Tyrrell, Jonathan M., Hinchliffe, Philip, Calvopiña, Karina, Tooke, Catherine L., Widlake, Emma, Dowson, Christopher G., Spencer, James, Walsh, Timothy R., Schofield, Christopher J., Brem, Jürgen

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Structural Basis of Metallo-β-lactamase Inhibition by N‑Sulfamoylpyrrole-2-carboxylates von Farley, Alistair J. M, Ermolovich, Yuri, Calvopiña, Karina, Rabe, Patrick, Panduwawala, Tharindi, Brem, Jürgen, Björkling, Fredrik, Schofield, Christopher J

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