Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl von Weisberg, Ellen, Manley, Paul W., Breitenstein, Werner, Brüggen, Josef, Cowan-Jacob, Sandra W., Ray, Arghya, Huntly, Brian, Fabbro, Doriano, Fendrich, Gabriele, Hall-Meyers, Elizabeth, Kung, Andrew L., Mestan, Jürgen, Daley, George Q., Callahan, Linda, Catley, Laurie, Cavazza, Cara, Mohammed, Azam, Neuberg, Donna, Wright, Renee D., Gilliland, D. Gary, Griffin, James D.

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Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor von Karpov, Alexei S, Amiri, Payman, Bellamacina, Cornelia, Bellance, Marie-Helene, Breitenstein, Werner, Daniel, Dylan, Denay, Regis, Fabbro, Doriano, Fernandez, Cesar, Galuba, Inga, Guerro-Lagasse, Stephanie, Gutmann, Sascha, Hinh, Linda, Jahnke, Wolfgang, Klopp, Julia, Lai, Albert, Lindvall, Mika K, Ma, Sylvia, Möbitz, Henrik, Pecchi, Sabina, Rummel, Gabriele, Shoemaker, Kevin, Trappe, Joerg, Voliva, Charles, Cowan-Jacob, Sandra W, Marzinzik, Andreas L

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Allosteric targeting resolves limitations of earlier LFA-1 directed modalities von Mancuso, Riccardo V., Schneider, Gisbert, Hürzeler, Marianne, Gut, Martin, Zurflüh, Jonas, Breitenstein, Werner, Bouitbir, Jamal, Reisen, Felix, Atz, Kenneth, Ehrhardt, Claus, Duthaler, Urs, Gygax, Daniel, Schmidt, Albrecht G., Krähenbühl, Stephan, Weitz-Schmidt, Gabriele

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ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans von John, Markus R, Widler, Leo, Gamse, Rainer, Buhl, Thomas, Seuwen, Klaus, Breitenstein, Werner, Bruin, Gerard J.M, Belleli, Rossella, Klickstein, Lloyd B, Kneissel, Michaela

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The Discovery of Novel Potent trans-3,4-Disubstituted Pyrrolidine Inhibitors of the Human Aspartic Protease Renin from in Silico Three-Dimensional (3D) Pharmacophore Searches von Lorthiois, Edwige, Breitenstein, Werner, Cumin, Frederic, Ehrhardt, Claus, Francotte, Eric, Jacoby, Edgar, Ostermann, Nils, Sellner, Holger, Kosaka, Takatoshi, Webb, Randy L, Rigel, Dean F, Hassiepen, Ulrich, Richert, Paul, Wagner, Trixie, Maibaum, Jürgen

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A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P 3 – P 1 Pharmacophore von Ostermann, Nils, Ruedisser, Simon, Ehrhardt, Claus, Breitenstein, Werner, Marzinzik, Andreas, Jacoby, Edgar, Vangrevelinghe, Eric, Ottl, Johannes, Klumpp, Martin, Hartwieg, J. Constanze D., Cumin, Frederic, Hassiepen, Ulrich, Trappe, Jörg, Sedrani, Richard, Geisse, Sabine, Gerhartz, Bernd, Richert, Paul, Francotte, Eric, Wagner, Trixie, Krömer, Markus, Kosaka, Takatoshi, Webb, Randy L., Rigel, Dean F., Maibaum, Jürgen, Baeschlin, Daniel K.

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A Novel Class of Oral Direct Renin Inhibitors: Highly Potent 3,5-Disubstituted Piperidines Bearing a Tricyclic P3 –P1 Pharmacophore von Ostermann, Nils, Ruedisser, Simon, Ehrhardt, Claus, Breitenstein, Werner, Marzinzik, Andreas, Jacoby, Edgar, Vangrevelinghe, Eric, Ottl, Johannes, Klumpp, Martin, Hartwieg, J. Constanze D, Cumin, Frederic, Hassiepen, Ulrich, Trappe, Jörg, Sedrani, Richard, Geisse, Sabine, Gerhartz, Bernd, Richert, Paul, Francotte, Eric, Wagner, Trixie, Krömer, Markus, Kosaka, Takatoshi, Webb, Randy L, Rigel, Dean F, Maibaum, Jürgen, Baeschlin, Daniel K

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New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck von Gommermann, Nina, Buehlmayer, Peter, von Matt, Anette, Breitenstein, Werner, Masuya, Keiichi, Pirard, Bernard, Furet, Pascal, Cowan-Jacob, Sandra W., Weckbecker, Gisbert

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1-Alkyl-4-phenyl-6-alkoxy-1H-quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists von Widler, Leo, Altmann, Eva, Beerli, René, Breitenstein, Werner, Bouhelal, Rochdi, Buhl, Thomas, Gamse, Rainer, Gerspacher, Marc, Halleux, Christine, John, Markus R, Lehmann, Hansjoerg, Kalb, Oskar, Kneissel, Michaela, Missbach, Martin, Müller, Irene R, Reidemeister, Sibylle, Renaud, Johanne, Taillardat, Agnes, Tommasi, Ruben, Weiler, Sven, Wolf, Romain M, Seuwen, Klaus

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Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases von Manley, Paul W., Breitenstein, Werner, Brüggen, Josef, Cowan-Jacob, Sandra W., Furet, Pascal, Mestan, Jürgen, Meyer, Thomas

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Structure-Based Design of Substituted Piperidines as a New Class of Highly Efficacious Oral Direct Renin Inhibitors von Ehara, Takeru, Irie, Osamu, Kosaka, Takatoshi, Kanazawa, Takanori, Breitenstein, Werner, Grosche, Philipp, Ostermann, Nils, Suzuki, Masaki, Kawakami, Shimpei, Konishi, Kazuhide, Hitomi, Yuko, Toyao, Atsushi, Gunji, Hiroki, Cumin, Frederic, Schiering, Nikolaus, Wagner, Trixie, Rigel, Dean F, Webb, Randy L, Maibaum, Jürgen, Yokokawa, Fumiaki

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The use of MPA amide for the assignment of absolute configuration of a sterically hindered cyclic secondary amine by 'mix and shake' NMR method von Gao, Jinhai, Haas, Hansjoerg, Wang, Kate Yaping, Chen, Zhuoliang, Breitenstein, Werner, Rajan, Srinivasan

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1-Alkyl-4-phenyl-6-alkoxy-1 H -quinazolin-2-ones: A Novel Series of Potent Calcium-Sensing Receptor Antagonists von Widler, Leo, Altmann, Eva, Beerli, René, Breitenstein, Werner, Bouhelal, Rochdi, Buhl, Thomas, Gamse, Rainer, Gerspacher, Marc, Halleux, Christine, John, Markus R., Lehmann, Hansjoerg, Kalb, Oskar, Kneissel, Michaela, Missbach, Martin, Müller, Irene R., Reidemeister, Sibylle, Renaud, Johanne, Taillardat, Agnes, Tommasi, Ruben, Weiler, Sven, Wolf, Romain M., Seuwen, Klaus

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Inhibitors of tyrosine kinases von Manley, Paul William, Breitenstein, Werner, Furet, Pascal, Jacob, Sandra

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Inhibitors of tyrosine kinases von Manley, Paul William, Breitenstein, Werner, Furet, Pascal, Jacob, Sandra

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Pseurotin B, C, D, and E. Further New Metabolites of Pseudeurotium ovalis STOLK von Breitenstein, Werner, Chexal, Kuldip K., Mohr, Peter, Tamm, Christoph

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Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl von Weisberg, Ellen, Manley, Paul W., Breitenstein, Werner, Brüggen, Josef, Cowan-Jacob, Sandra W., Ray, Arghya, Huntly, Brian, Fabbro, Doriano, Fendrich, Gabriele, Hall-Meyers, Elizabeth, Kung, Andrew L., Mestan, Jürgen, Daley, George Q., Callahan, Linda, Catley, Laurie, Cavazza, Cara, Azam, Mohammad, Neuberg, Donna, Wright, Renee D., Gilliland, D. Gary, Griffin, James D.

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SMALL MOLECULE LFA-1 INHIBITORS von MANCUSO, Riccardo, WEITZ-SCHMIDT, Gabriele, SCHNEIDER, Gisbert, KELLY, Terence, BREITENSTEIN, Werner, HUERZELER, Marianne

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SMALL MOLECULE LFA-1 INHIBITORS von MANCUSO, Riccardo, WEITZ-SCHMIDT, Gabriele, SCHNEIDER, Gisbert, KELLY, Terence, BREITENSTEIN, Werner, HUERZELER, Marianne

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Small molecule LFA-1 inhibitors von Breitenstein, Werner, Schneider, Gisbert, Weitz-Schmidt, Gabriele, Huerzeler, Marianne, Mancuso, Riccardo, Kelly, Terence

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