Efficient Payload Delivery by a Bispecific Antibody-Drug Conjugate Targeting HER2 and CD63 von de Goeij, Bart E C G, Vink, Tom, Ten Napel, Hendrik, Breij, Esther C W, Satijn, David, Wubbolts, Richard, Miao, David, Parren, Paul W H I

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Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy von Da Roit, Fabio, Engelberts, Patrick J, Taylor, Ronald P, Breij, Esther C W, Gritti, Giuseppe, Rambaldi, Alessandro, Introna, Martino, Parren, Paul W H I, Beurskens, Frank J, Golay, Josée

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DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing von Engelberts, Patrick J., Hiemstra, Ida H., de Jong, Bart, Schuurhuis, Danita H., Meesters, Joyce, Beltran Hernandez, Irati, Oostindie, Simone C., Neijssen, Joost, van den Brink, Edward N., Horbach, G. Jean, Verploegen, Sandra, Labrijn, Aran F., Salcedo, Theodora, Schuurman, Janine, Parren, Paul W.H.I, Breij, Esther C.W.

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Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia von TROMP, Jacqueline M, GEEST, Christian R, BREIJ, Esther C. W, ELIAS, Judith A, LAAR, Jacoline Van, LUIJKS, Dieuwertje M, KATER, Arnon P, BEAUMONT, Tim, OERS, Marinus H. J. Van, ELDERING, Eric

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An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation von Muik, Alexander, Altintas, Isil, Gieseke, Friederike, Schoedel, Kristina B, Burm, Saskia M, Toker, Aras, Salcedo, Theodora W., Verzijl, Dennis, Eisel, David, Grunwitz, Christian, Kranz, Lena M, Vormehr, Mathias, Satijn, David P.E., Diken, Mustafa, Kreiter, Sebastian, Sasser, Kate, Ahmadi, Tahamtan, Türeci, Özlem, Breij, Esther C.W., Jure-Kunkel, Maria, Sahin, Ugur

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Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors von Boshuizen, Julia, Koopman, Louise A, Krijgsman, Oscar, Shahrabi, Aida, van den Heuvel, Elke Gresnigt–, Ligtenberg, Maarten A, Vredevoogd, David W, Kemper, Kristel, Kuilman, Thomas, Song, Ji-Ying, Pencheva, Nora, Mortensen, Jens Thing, Foppen, Marnix Geukes, Rozeman, Elisa A, Blank, Christian U, Janmaat, Maarten L, Satijn, David, Breij, Esther C W, Peeper, Daniel S, Parren, Paul W H I

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An Antibody-Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors von BREIJ, Esther C. W, DE GOEIJ, Bart E. C. G, PARREN, Paul W. H. I, VERPLOEGEN, Sandra, SCHUURHUIS, Danita H, AMIRKHOSRAVI, Ali, FRANCIS, John, MILLER, Vibeke Breinholt, HOUTKAMP, Mischa, BLEEKER, Wim K, SATIJN, David

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Dual Epitope Targeting and Enhanced Hexamerization by DR5 Antibodies as a Novel Approach to Induce Potent Antitumor Activity Through DR5 Agonism von Overdijk, Marije B., Strumane, Kristin, Beurskens, Frank J., Buijsse, Antonio Ortiz, Vermot-Desroches, Claudine, Vuillermoz, Boris S., Kroes, Thessa, de Jong, Bart, Hoevenaars, Naomi, Hibbert, Richard G., Lingnau, Andreas, Forssmann, UIf, Schuurman, Janine, Parren, Paul W. H., de Jong, Rob N., Breij, Esther C. W.

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Homogeneity of active demyelinating lesions in established multiple sclerosis von Breij, Esther C. W., Brink, Bianca P., Veerhuis, Rob, van den Berg, Christa, Vloet, Rianka, Yan, Riqiang, Dijkstra, Christine D., van der Valk, Paul, Bö, Lars

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CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering von Oostindie, Simone C, van der Horst, Hilma J, Lindorfer, Margaret A, Cook, Erika M, Tupitza, Jillian C, Zent, Clive S, Burack, Richard, VanDerMeid, Karl R, Strumane, Kristin, Chamuleau, Martine E D, Mutis, Tuna, de Jong, Rob N, Schuurman, Janine, Breij, Esther C W, Beurskens, Frank J, Parren, Paul W H I, Taylor, Ronald P

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Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment von van der Horst, Hilma J., de Jonge, A. Vera, Hiemstra, Ida H., Gelderloos, Anne T., Berry, Daniella R. A. I., Hijmering, Nathalie J., van Essen, Hendrik F., de Jong, Daphne, Chamuleau, Martine E. D., Zweegman, Sonja, Breij, Esther C. W., Roemer, Margaretha G. M., Mutis, Tuna

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Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells von Engelberts, Patrick J, Voorhorst, Marleen, Schuurman, Janine, van Meerten, Tom, Bakker, Joost M, Vink, Tom, Mackus, Wendy J M, Breij, Esther C W, Derer, Stefanie, Valerius, Thomas, van de Winkel, Jan G J, Parren, Paul W H I, Beurskens, Frank J

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Antibodies as drugs—a Keystone Symposia report von Cable, Jennifer, Saphire, Erica Ollmann, Hayday, Adrian C., Wiltshire, Timothy D., Mousa, Jarrod J., Humphreys, David P., Breij, Esther C. W., Bruhns, Pierre, Broketa, Matteo, Furuya, Genta, Hauser, Blake M., Mahévas, Matthieu, Carfi, Andrea, Cantaert, Tineke, Kwong, Peter D., Tripathi, Prabhanshu, Davis, Jonathan H., Brewis, Neil, Keyt, Bruce A., Fennemann, Felix L., Dussupt, Vincent, Sivasubramanian, Arvind, Kim, Philip M., Rawi, Reda, Richardson, Eve, Leventhal, Daniel, Wolters, Rachael M., Geuijen, Cecile A. W., Sleeman, Matthew A., Pengo, Niccolo, Donnellan, Francesca Rose

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Duobody-CD3xCD30 Demonstrates Potent Anti-Tumor Activity in Preclinical Models of CD30+ Hematologic Malignancies von Oostindie, Simone C., Alemdehy, Mir Farshid, Janmaat, Maarten L., Meerding, Jenny M., Kemper, Kristel, Engelberts, Patrick J., De Goeij, Bart E.C.G., Satijn, David, Sasser, A. Kate, Breij, Esther C.W.

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Preliminary Dose-Escalation Results from a Phase 1/2 Study of GEN3014 (HexaBody®-CD38) in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM) von Spencer, Andrew, Iversen, Katrine Fladeland, Dhakal, Binod, Creignou, Maria, Chen, Jenny, Hiemstra, Ida H, Bosgra, Sieto, Badani, Avani, Breij, Esther C.W., Brady, Lauren K., Sasser, A. Kate, Malmberg, Anders, Gregersen, Henrik, Hansson, Markus, Broijl, Annemiek, Mateos, Maria-Victoria, Plesner, Torben

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DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies von Oostindie, Simone C., van der Horst, Hilma J., Kil, Laurens P., Strumane, Kristin, Overdijk, Marije B., van den Brink, Edward N., van den Brakel, Jeroen H. N., Rademaker, Hendrik J., van Kessel, Berris, van den Noort, Juliette, Chamuleau, Martine E. D., Mutis, Tuna, Lindorfer, Margaret A., Taylor, Ronald P., Schuurman, Janine, Parren, Paul W. H. I., Beurskens, Frank J., Breij, Esther C. W.

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DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity von Muik, Alexander, Adams III, Homer C, Gieseke, Friederike, Altintas, Isil, Schoedel, Kristina B, Blum, Jordan M, Sänger, Bianca, Burm, Saskia M, Stanganello, Eliana, Verzijl, Dennis, Spires, Vanessa M, Vascotto, Fulvia, Toker, Aras, Quinkhardt, Juliane, Fereshteh, Mark, Diken, Mustafa, Satijn, David P E, Kreiter, Sebastian, Ahmadi, Tahamtan, Breij, Esther C W, Türeci, Özlem, Sasser, Kate, Sahin, Ugur, Jure-Kunkel, Maria

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Cytotoxicity of the CD3×CD20 bispecific antibody epcoritamab in CLL is increased by concurrent BTK or BCL-2 targeting von Mhibik, Maissa, Gaglione, Erika M., Eik, David, Herrick, John, Le, Janet, Ahn, Inhye E., Chiu, Christopher, Wielgos-Bonvallet, Monica, Hiemstra, Ida H., Breij, Esther C. W., Chen, Jenny, Reilly, Edward B., Epling-Burnette, Pearlie K., Szafer-Glusman, Edith, Sun, Clare, Wiestner, Adrian

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Response to Comment on "Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells" von Engelberts, Patrick J, Breij, Esther C W, Valerius, T, Schuurman, J, Parren, Paul W H I, Beurskens, F J

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