Effects of Omeprazole on Plasma Levels of Raltegravir von Iwamoto, Marian, Wenning, Larissa A., Nguyen, Bach-Yen, Teppler, Hedy, Moreau, Allison R., Rhodes, Rand R., Hanley, William D., Jin, Bo, Harvey, Charlotte M., Breidinger, Sheila A., Azrolan, Neal, Farmer, H. Frank, Isaacs, Robin D., Chodakewitz, Jeffery A., Stone, Julie A., Wagner, John A.

Volltext

Lack of a Significant Drug Interaction between Raltegravir and Tenofovir von WENNING, Larissa A, FRIEDMAN, Evan J, STONE, Julie A, IWAMOTO, Marian, KOST, James T, BREIDINGER, Sheila A, STEK, Jon E, LASSETER, Kenneth C, GOTTESDIENER, Keith M, CHEN, Joshua, TEPPLER, Hedy, WAGNER, John A

Volltext

Minimal Effects of Ritonavir and Efavirenz on the Pharmacokinetics of Raltegravir von IWAMOTO, Marian, WENNING, Larissa A, HAAZEN, Wouter, STONE, Julie A, GOTTESDIENER, Keith M, WAGNER, John A, PETRY, Amelia S, LAETHEM, Martine, DE SMET, Marina, KOST, James T, BREIDINGER, Sheila A, MANGIN, Eric C, AZROLAN, Neal, GREENBERG, Howard E

Volltext

Lack of a Clinically Important Effect of Moderate Hepatic Insufficiency and Severe Renal Insufficiency on Raltegravir Pharmacokinetics von IWAMOTO, Marian, HANLEY, William D, STONE, Julie A, WAGNER, John A, PETRY, Amelia S, FRIEDMAN, Evan J, KOST, James T, BREIDINGER, Sheila A, LASSETER, Kenneth C, ROBSON, Richard, LUNDE, Norman M, WENNING, Larissa A

Volltext

Effect of Low-, Moderate-, and High-Fat Meals on Raltegravir Pharmacokinetics von Brainard, Diana M., Friedman, Evan J., Jin, Bo, Breidinger, Sheila A., Tillan, Maria D., Wenning, Larissa A., Stone, Julie A., Chodakewitz, Jeffrey A., Wagner, John A., Iwamoto, Marian

Volltext

Extractability-mediated stability bias and hematocrit impact: High extraction recovery is critical to feasibility of volumetric adsorptive microsampling (VAMS) in regulated bioanal... von Xie, Iris, Xu, Yang, Anderson, Melanie, Wang, Ming, Xue, Lingling, Breidinger, Sheila, Goykhman, Dina, Woolf, Eric J., Bateman, Kevin P.

Volltext

Incorporating protein precipitation to resolve hybrid IP-LC-MS assay interference for ultrasensitive quantification of intact therapeutic insulin dimer in human plasma von Sun, Li, Xu, Yang, Dube, Neal, Anderson, Melanie, Breidinger, Sheila, Vaddady, Pavan, Thornton, Bob, Morrow, Linda, Matthews, Randolph P., Stoch, S. Aubrey, Woolf, Eric J.

Volltext

An Investigation of Instability in Dried Blood Spot Samples for Pharmacokinetic Sampling in Phase 3 Trials of Verubecestat von Anderson, Melanie, Dockendorf, Marissa F., McIntosh, Ian, Xie, Iris, Breidinger, Sheila, Meng, Dongfang, Ren, Sumei, Zhong, Wendy, Zhang, Li, Roadcap, Brad, Bateman, Kevin P., Stone, Julie, Woolf, Eric

Volltext

Total Raltegravir Concentrations in Cerebrospinal Fluid Exceed the 50-Percent Inhibitory Concentration for Wild-Type HIV-1 von CROTEAU, David, LETENDRE, Scott, MCCUTCHAN, Allen, MORGELLO, Susan, SIMPSON, David, WAY, Lauren, VAIDA, Florin, UELAND, Susan, CAPPARELLI, Edmund, GRANT, Igor, BEST, Brookie M, ELLIS, Ronald J, BREIDINGER, Sheila, CLIFFORD, David, COLLIER, Ann, GELMAN, Benjamin, MARRA, Christina, MBEO, Gilbert

Volltext

Current status of bioanalytical outsourcing: a pharma perspective

Volltext

A Model-Based Approach to Bridging Plasma and Dried Blood Spot Concentration Data for Phase 3 Verubecestat Trials von Dockendorf, Marissa F., Jaworowicz, David, Humphrey, Rebecca, Anderson, Melanie, Breidinger, Sheila, Ma, Lei, Taylor, Theresa, Dupre, Nicole, Jones, Christopher, Furtek, Christine, Kantesaria, Bhavna, Bateman, Kevin P., Woolf, Eric, Egan, Michael F., Stone, Julie A.

Volltext

Insulin glargine and its two active metabolites: A sensitive (16pM) and robust simultaneous hybrid assay coupling immunoaffinity purification with LC–MS/MS to support biosimilar cl... von Xu, Yang, Sun, Li, Anderson, Melanie, Bélanger, Philippe, Trinh, Vincent, Lavallée, Patricia, Kantesaria, Bhavna, Marcoux, Marie-Josée, Breidinger, Sheila, Bateman, Kevin P., Goykhman, Dina, Woolf, Eric J.

Volltext

Atazanavir Modestly Increases Plasma Levels of Raltegravir in Healthy Subjects von Iwamoto, Marian, Wenning, Larissa A., Mistry, Goutam C., Petry, Amelia S., Liou, Sarah Y., Ghosh, Kaylan, Breidinger, Sheila, Azrolan, Neal, Gutierrez, Maria J., Bridson, William E., Stone, Julie A., Gottesdiener, Keith M., Wagner, John A.

Volltext

Ultrasensitive Liquid Chromatography–Tandem Mass Spectrometric Methodologies for Quantification of Five HIV‑1 Integrase Inhibitors in Plasma for a Microdose Clinical Trial von Sun, Li, Li, Hankun, Willson, Kenneth, Breidinger, Sheila, Rizk, Matthew L, Wenning, Larissa, Woolf, Eric J

Volltext

Strategy for peptide quantification using LC-MS in regulated bioanalysis: case study with a glucose-responsive insulin von Xu, Yang, Goykhman, Dina, Wang, Ming, Jackson, Tonya, Xie, Iris, Willson, Kenneth, Breidinger, Sheila, Schuck, Helengrace, Harrelson, Jane, Woolf, Eric J

Volltext

Toward highly sensitive and reproducible LC-MS/MS analysis of MK-8591 phosphorylated anabolites in human peripheral blood mononuclear cells von Sun, Li, Chavez-Eng, Cynthia, Fillgrove, Kerry L, Lu, Bing, Xie, Iris, Rudd, Deanne Jackson, Breidinger, Sheila, Anderson, Melanie, Yeh, Suzie, Zhang, Rena, Woolf, Eric J

Volltext

Report on the 17th Annual Land O'Lakes Bioanalytical Conference von Burns, Erik C, Moran, Jeff, Breidinger, Sheila, Ho, Stacy, Guthrie, Randy, Amaravardi, Lakshmi

Volltext

Pharmacokinetics and safety of twice-daily atazanavir 300 mg and raltegravir 400 mg in healthy individuals von LI ZHU, BUTTERTON, Joan, PERSSON, Anna, STONIER, Michele, COMISAR, Wendy, PANEBIANCO, Deborah, BREIDINGER, Sheila, ZHANG, Jenny, BERTZ, Richard

Volltext

Quantitative determination of odanacatib in human plasma using liquid–liquid extraction followed by liquid chromatography–tandem mass spectrometry analysis von Sun, Li, Forni, Sabrina, Schwartz, Michael S., Breidinger, Sheila, Woolf, Eric J.

Volltext

Lack of meaningful effect of ridaforolimus on the pharmacokinetics of midazolam in cancer patients: Model prediction and clinical confirmation von Stroh, Mark, Talaty, Jennifer, Sandhu, Punam, McCrea, Jacqueline, Patnaik, Amita, Tolcher, Anthony, Palcza, John, Orford, Keith, Breidinger, Sheila, Narasimhan, Narayana, Panebianco, Deborah, Lush, Richard, Papadopoulos, Kyriakos P., Wagner, John A., Trucksis, Michele, Agrawal, Nancy

Volltext