Clinical correlates of circulating cell-free DNA tumor fraction von Bredno, Joerg, Lipson, Jafi, Venn, Oliver, Aravanis, Alexander M, Jamshidi, Arash

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A DNA methylation atlas of normal human cell types von Loyfer, Netanel, Magenheim, Judith, Peretz, Ayelet, Cann, Gordon, Bredno, Joerg, Klochendler, Agnes, Fox-Fisher, Ilana, Shabi-Porat, Sapir, Hecht, Merav, Pelet, Tsuria, Moss, Joshua, Drawshy, Zeina, Amini, Hamed, Moradi, Patriss, Nagaraju, Sudharani, Bauman, Dvora, Shveiky, David, Porat, Shay, Dior, Uri, Rivkin, Gurion, Or, Omer, Hirshoren, Nir, Carmon, Einat, Pikarsky, Alon, Khalaileh, Abed, Zamir, Gideon, Grinbaum, Ronit, Abu Gazala, Machmud, Mizrahi, Ido, Shussman, Noam, Korach, Amit, Wald, Ori, Izhar, Uzi, Erez, Eldad, Yutkin, Vladimir, Samet, Yaacov, Rotnemer Golinkin, Devorah, Spalding, Kirsty L., Druid, Henrik, Arner, Peter, Shapiro, A. M. James, Grompe, Markus, Aravanis, Alex, Venn, Oliver, Jamshidi, Arash, Shemer, Ruth, Dor, Yuval, Glaser, Benjamin, Kaplan, Tommy

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Circulating Tumor DNA Allele Fraction: A Candidate Biological Signal for Multicancer Early Detection Tests to Assess the Clinical Significance of Cancers von Bredno, Joerg, Venn, Oliver, Chen, Xiaoji, Freese, Peter, Ofman, Joshua J

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Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA von Liu, M.C., Klein, E.A., Swanton, C., Seiden, M.V., Klein, Eric A., Yeatman, Timothy J., Cohn, Allen L., Lapham, Rosanna, Parker, Alexander S., McIntyre, Kristi, Sekeres, Mikkael A., Siegel, Robert, Wang, Xuezhong, Cosgrove, David P., Trent, Jonathan, Thiel, David D., Garbo, Lawrence E., Giguere, Jeffrey K., Michels, Ross M., Harris, Ronald P., Richey, Stephen L., McCarthy, Timothy A., Couch, Fergus J., Wilks, Sharon T., Krie, Amy K., Balaraman, Rama, Rieger-Christ, Kimberly, Sullivan, Travis, Greenwald, Daniel R., Oh, William, Tsao, Che-Kai, Kennecke, Hagen F., Manhas, Atisha P., Ulrich, Brian K., Kovoor, Philip A., Stokoe, Christopher, Courtright, Jay G., Larson, Timothy G., Seiden, Michael V., Cummings, Steven R., Absalan, Farnaz, Alexander, Gregory, Allen, Brian, Aravanis, Alexander M., Beausang, John F., Berman, Jennifer, Bredno, Joerg, Calef, Robert, Cann, Gordon, Carter, Jeremy, Chen, Xiaoji, Chien, Tom C., Davydov, Konstantin, Demas, Vasiliki, Fields, Alexander P., Freese, Peter, Gnerre, Sante, Gross, Samuel, Hall, Megan P., Hartman, Anne-Renee, Hou, Chenlu, Hubbell, Earl, Jiang, Roger, Kim, TaeHyung, Klausner, Richard D., Kurtzman, Kathryn N., Lee, Mark, Lin, Wendy, Lipson, Jafi, Maddala, Tara, Maher, M. Cyrus, Melton, Collin, Mich, Andrea, Newman, Joshua, Nicula, Virgil, Nikolic, Ongjen, Patel, Shilpen, Rava, Richard, Schellenberger, Jan, Scott, Eric, Sehnert, Amy J., Shaknovich, Rita, Shanmugam, Avinash, Shashidhar, K.C., Shenoy, Archana, Shojaee, Seyedmehdi, Tang, Susan, Valouev, Anton, Venn, Oliver, Williams, Richard T., Wu, Tony, Yakym, Christopher, Yang, Xiao, Yecies, Jessica, Yip, Alexander S., Yue, Jeanne, Zhang, Lily, Zhang, Lori (Quan), Curtis, Christina, Berry, Donald A.

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Circulating Tumor DNA Allele Fraction von Bredno, Joerg, Venn, Oliver, Chen, Xiaoji, Freese, Peter, Ofman, Joshua J.

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Intertumoral Heterogeneity of CD3 + and CD8 + T-Cell Densities in the Microenvironment of DNA Mismatch-Repair-Deficient Colon Cancers: Implications for Prognosis von Yoon, Harry H, Shi, Qian, Heying, Erica N, Muranyi, Andrea, Bredno, Joerg, Ough, Faith, Djalilvand, Azita, Clements, June, Bowermaster, Rebecca, Liu, Wen-Wei, Barnes, Michael, Alberts, Steven R, Shanmugam, Kandavel, Sinicrope, Frank A

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Clinical Utility of Tumor-Naïve Presurgical Circulating Tumor DNA Detection in Early-Stage NSCLC von Hong, Tae Hee, Hwang, Soohyun, Dasgupta, Abhijit, Abbosh, Chris, Hung, Tiffany, Bredno, Jörg, Walker, Jill, Shi, Xiaojin, Milenkova, Tsveta, Horn, Leora, Choi, Joon Young, Lee, Ho Yun, Cho, Jong Ho, Choi, Yong Soo, Shim, Young Mog, Chai, Shoujie, Rhodes, Kate, Roychowdhury-Saha, Manami, Hodgson, Darren, Kim, Hong Kwan, Ahn, Myung-Ju

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Reperfusion is a more accurate predictor of follow-up infarct volume than recanalization: a proof of concept using CT in acute ischemic stroke patients von Soares, Bruno P, Tong, Elizabeth, Hom, Jason, Cheng, Su-Chun, Bredno, Joerg, Boussel, Loic, Smith, Wade S, Wintermark, Max

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Abstract 2114: HPV-driven cancers show distinct methylation signatures in cell-free DNA (cfDNA) von Calef, Robert, Venn, Oliver, Maher, M. Cyrus, Beausang, John F., Hubbell, Earl, Patel, Aman, Fields, Alexander P., Bredno, Joerg, Jamshidi, Arash, Aravanis, Alexander M.

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High and Low Molecular Weight Fluorescein Isothiocyanate (FITC)–Dextrans to Assess Blood-Brain Barrier Disruption: Technical Considerations von Hoffmann, Angelika, Bredno, Jörg, Wendland, Michael, Derugin, Nikita, Ohara, Peter, Wintermark, Max

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Abstract C139: The robustness of a targeted methylation-based multi-cancer early detection (MCED) test to population differences in self-reported ethnicity von Venn, Oliver, Bredno, Joerg, Thornton, Alexis, Hubbell, Earl, Kurtzman, Kathryn, Beausang, John, Swanton, Charles

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PP01.92 Analytical performance of a cell-free DNA targeted methylation test for early lung adenocarcinoma (LUAD) recurrence assessment von Roychowdhury-Saha, Manami, Adhikari, Sanjay, Aiello, Anna Carla, L'Hernault, Anne, Pathak, Aparna, Chai, Shoujie, Zhao, Mary, Sharma, Manoj, Shchegrov, Svetlana Rakhmanova, Nguyen, Tracy, Revenkova, Ekaterina, Xiao, Vivian, Bredno, Joerg, Scott, Eric, Hung, Tiffany, Abbosh, Chris, Walker, Jill, Shaknovich, Rita, Jung, Byoungsok, Rhodes, Kate

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Abstract 2308: Classifier performance of a cfDNA-based multi-cancer detection test on uncommon cancer types von Bredno, Joerg, Gross, Samuel, Fields, Alexander P., Kurtzman, Kathryn N., Shaknovich, Rita, Yecies, Jessica, Chen, Xiaoji, Schellenberger, Jan, Scott, Eric, Dong, Zhao, Fung, Eric T., Hartman, Anne-Renee, Hubbell, Earl, Jamshidi, Arash, Aravanis, Alexander M., Venn, Oliver

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Tu1836 TUMOR AREA AND MICROSCOPIC EXTENT OF INVASION DETERMINE CIRCULATING TUMOR CELL-FREE DNA FRACTION IN PLASMA AND DETECTABILITY OF COLORECTAL CANCER von Bredno, Joerg, Lipson, Jafi, Venn, Oliver, Gross, Samuel, Fields, Alexander P., Beausang, John, Liu, Qinwen, Brooks, Jackie, Chen, Xiaoji, Lopatin, Margarita, Liu, Hai, Zhang, Nan, Zhang, Lori, Wu, Tony, Allen, Brian, Hartman, Anne-Renee, Hubbell, Earl, Jamshidi, Arash, Aravanis, Alexander

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Simulation model for contrast agent dynamics in brain perfusion scans von Bredno, Jörg, Olszewski, Mark E., Wintermark, Max

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Abstract P5-01-01: Blood-based cancer detection in plasma cell-free DNA (cfDNA): Evaluating clinical and pathologic tumor characteristics in participants with breast cancer von Liu, Minetta C., Carter, Jodi M., Visscher, Daniel W., Kopp, Karla, Shaknovich, Rita, Chen, Xiaoji, Kurtzman, Kathryn N., Patel, Shilpen, Brooks, Jacqueline D., Cosenza, Carlo R., Lipson, Jafi A., Richards, Donald A., Couch, Fergus J., Dong, Zhao, Liu, Hai, Venn, Oliver, Bredno, Joerg, Fung, Eric T., Hartman, Anne-Renee

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Performance of a blood-based test for the detection of multiple cancer types von Wolpin, Brian M., Richards, Donald A., Cohn, Allen Lee, Chen, Xiaoji, Bredno, Joerg, Kurtzman, Kathryn N., Yecies, Jessica, Shaknovich, Rita, Zhang, Nan, Tummala, Mohan K., Spigel, David R., Cosgrove, David, Wilks, Sharon, Siegel, Robert D., Fung, Eric T., Jamshidi, Arash, Aravanis, Alex, Hartman, Anne-Renee, Liu, Minetta C., Klein, Eric A.

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Tumor area and microscopic extent of invasion to determine circulating tumor DNA fraction in plasma and detectability of colorectal cancer (CRC) von Bredno, Joerg, Lipson, Jafi, Venn, Oliver, Gross, Samuel, Fields, Alexander P., Beausang, John F., Liu, Qinwen, Brooks, Jacqueline D., Chen, Xiaoji, Lopatin, Rita, Liu, Hai, Zhang, Nan, Zhang, Lori, Wu, Tony, Allen, Brian, Hartman, Anne-Renee, Hubbell, Earl, Jamshidi, Arash, Aravanis, Alex

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Inter-tumoral heterogeneity of CD3+ and CD8+ T-cell densities in the microenvironment of DNA mismatch repair-deficient colon cancers: implications for prognosis von Yoon, Harry H., Shi, Qian, Heying, Erica N., Muranyi, Andrea, Bredno, Joerg, Ough, Faith, Djalilvand, Azita, Clements, June, Bowermaster, Rebecca, Liu, Wen-Wei, Barnes, Michael, Alberts, Steven R., Shanmugam, Kandavel, Sinicrope, Frank A.

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Abstract 1600: Expanded multiplexing capability in brightfield immunohistochemistry utilizing multiple chromogen chemistries and detection enzymes von Roberts, Esteban, Day, William, Kelly, Brian D., Polaske, Nathan W., Ashworth-Sharpe, Julia, Johnson, Donald, Lefever, Mark, Kosmeder, Jerry, Zhang, Hongjun, Zhang, Jian, Tsao, Tsu-Shuen, Farrell, Mike, Bredno, Joerg, Ochs, Robert, Morrison, Larry

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