Clinical correlates of circulating cell-free DNA tumor fraction von Bredno, Joerg, Lipson, Jafi, Venn, Oliver, Aravanis, Alexander M., Jamshidi, Arash

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Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA von Liu, M.C., Klein, E.A., Swanton, C., Seiden, M.V., Klein, Eric A., Yeatman, Timothy J., Cohn, Allen L., Lapham, Rosanna, Parker, Alexander S., McIntyre, Kristi, Sekeres, Mikkael A., Siegel, Robert, Wang, Xuezhong, Cosgrove, David P., Trent, Jonathan, Thiel, David D., Garbo, Lawrence E., Giguere, Jeffrey K., Michels, Ross M., Harris, Ronald P., Richey, Stephen L., McCarthy, Timothy A., Couch, Fergus J., Wilks, Sharon T., Krie, Amy K., Balaraman, Rama, Rieger-Christ, Kimberly, Sullivan, Travis, Greenwald, Daniel R., Oh, William, Tsao, Che-Kai, Kennecke, Hagen F., Manhas, Atisha P., Ulrich, Brian K., Kovoor, Philip A., Stokoe, Christopher, Courtright, Jay G., Larson, Timothy G., Seiden, Michael V., Cummings, Steven R., Absalan, Farnaz, Alexander, Gregory, Allen, Brian, Aravanis, Alexander M., Beausang, John F., Berman, Jennifer, Bredno, Joerg, Calef, Robert, Cann, Gordon, Carter, Jeremy, Chen, Xiaoji, Chien, Tom C., Davydov, Konstantin, Demas, Vasiliki, Fields, Alexander P., Freese, Peter, Gnerre, Sante, Gross, Samuel, Hall, Megan P., Hartman, Anne-Renee, Hou, Chenlu, Hubbell, Earl, Jiang, Roger, Kim, TaeHyung, Klausner, Richard D., Kurtzman, Kathryn N., Lee, Mark, Lin, Wendy, Lipson, Jafi, Maddala, Tara, Maher, M. Cyrus, Melton, Collin, Mich, Andrea, Newman, Joshua, Nicula, Virgil, Nikolic, Ongjen, Patel, Shilpen, Rava, Richard, Schellenberger, Jan, Scott, Eric, Sehnert, Amy J., Shaknovich, Rita, Shanmugam, Avinash, Shashidhar, K.C., Shenoy, Archana, Shojaee, Seyedmehdi, Tang, Susan, Valouev, Anton, Venn, Oliver, Williams, Richard T., Wu, Tony, Yakym, Christopher, Yang, Xiao, Yecies, Jessica, Yip, Alexander S., Yue, Jeanne, Zhang, Lily, Zhang, Lori (Quan), Curtis, Christina, Berry, Donald A.

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A DNA methylation atlas of normal human cell types von Loyfer, Netanel, Magenheim, Judith, Peretz, Ayelet, Cann, Gordon, Bredno, Joerg, Klochendler, Agnes, Fox-Fisher, Ilana, Shabi-Porat, Sapir, Hecht, Merav, Pelet, Tsuria, Moss, Joshua, Drawshy, Zeina, Amini, Hamed, Moradi, Patriss, Nagaraju, Sudharani, Bauman, Dvora, Shveiky, David, Porat, Shay, Dior, Uri, Rivkin, Gurion, Or, Omer, Hirshoren, Nir, Carmon, Einat, Pikarsky, Alon, Khalaileh, Abed, Zamir, Gideon, Grinbaum, Ronit, Abu Gazala, Machmud, Mizrahi, Ido, Shussman, Noam, Korach, Amit, Wald, Ori, Izhar, Uzi, Erez, Eldad, Yutkin, Vladimir, Samet, Yaacov, Rotnemer Golinkin, Devorah, Spalding, Kirsty L., Druid, Henrik, Arner, Peter, Shapiro, A. M. James, Grompe, Markus, Aravanis, Alex, Venn, Oliver, Jamshidi, Arash, Shemer, Ruth, Dor, Yuval, Glaser, Benjamin, Kaplan, Tommy

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Intertumoral Heterogeneity of CD3 + and CD8 + T-Cell Densities in the Microenvironment of DNA Mismatch-Repair-Deficient Colon Cancers: Implications for Prognosis von Yoon, Harry H, Shi, Qian, Heying, Erica N, Muranyi, Andrea, Bredno, Joerg, Ough, Faith, Djalilvand, Azita, Clements, June, Bowermaster, Rebecca, Liu, Wen-Wei, Barnes, Michael, Alberts, Steven R, Shanmugam, Kandavel, Sinicrope, Frank A

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Clinical Utility of Tumor-Naïve Presurgical Circulating Tumor DNA Detection in Early-Stage NSCLC von Hong, Tae Hee, Hwang, Soohyun, Dasgupta, Abhijit, Abbosh, Chris, Hung, Tiffany, Bredno, Jörg, Walker, Jill, Shi, Xiaojin, Milenkova, Tsveta, Horn, Leora, Choi, Joon Young, Lee, Ho Yun, Cho, Jong Ho, Choi, Yong Soo, Shim, Young Mog, Chai, Shoujie, Rhodes, Kate, Roychowdhury-Saha, Manami, Hodgson, Darren, Kim, Hong Kwan, Ahn, Myung-Ju

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Reperfusion is a more accurate predictor of follow-up infarct volume than recanalization: a proof of concept using CT in acute ischemic stroke patients von Soares, Bruno P, Tong, Elizabeth, Hom, Jason, Cheng, Su-Chun, Bredno, Joerg, Boussel, Loic, Smith, Wade S, Wintermark, Max

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Abstract C139: The robustness of a targeted methylation-based multi-cancer early detection (MCED) test to population differences in self-reported ethnicity von Venn, Oliver, Bredno, Joerg, Thornton, Alexis, Hubbell, Earl, Kurtzman, Kathryn, Beausang, John, Swanton, Charles

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PP01.92 Analytical performance of a cell-free DNA targeted methylation test for early lung adenocarcinoma (LUAD) recurrence assessment von Roychowdhury-Saha, Manami, Adhikari, Sanjay, Aiello, Anna Carla, L'Hernault, Anne, Pathak, Aparna, Chai, Shoujie, Zhao, Mary, Sharma, Manoj, Shchegrov, Svetlana Rakhmanova, Nguyen, Tracy, Revenkova, Ekaterina, Xiao, Vivian, Bredno, Joerg, Scott, Eric, Hung, Tiffany, Abbosh, Chris, Walker, Jill, Shaknovich, Rita, Jung, Byoungsok, Rhodes, Kate

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Abstract 2308: Classifier performance of a cfDNA-based multi-cancer detection test on uncommon cancer types von Bredno, Joerg, Gross, Samuel, Fields, Alexander P., Kurtzman, Kathryn N., Shaknovich, Rita, Yecies, Jessica, Chen, Xiaoji, Schellenberger, Jan, Scott, Eric, Dong, Zhao, Fung, Eric T., Hartman, Anne-Renee, Hubbell, Earl, Jamshidi, Arash, Aravanis, Alexander M., Venn, Oliver

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Simulation model for contrast agent dynamics in brain perfusion scans von Bredno, Jörg, Olszewski, Mark E., Wintermark, Max

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Tumor area and microscopic extent of invasion to determine circulating tumor DNA fraction in plasma and detectability of colorectal cancer (CRC) von Bredno, Joerg, Lipson, Jafi, Venn, Oliver, Gross, Samuel, Fields, Alexander P., Beausang, John F., Liu, Qinwen, Brooks, Jacqueline D., Chen, Xiaoji, Lopatin, Rita, Liu, Hai, Zhang, Nan, Zhang, Lori, Wu, Tony, Allen, Brian, Hartman, Anne-Renee, Hubbell, Earl, Jamshidi, Arash, Aravanis, Alex

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Performance of a blood-based test for the detection of multiple cancer types von Wolpin, Brian M., Richards, Donald A., Cohn, Allen Lee, Chen, Xiaoji, Bredno, Joerg, Kurtzman, Kathryn N., Yecies, Jessica, Shaknovich, Rita, Zhang, Nan, Tummala, Mohan K., Spigel, David R., Cosgrove, David, Wilks, Sharon, Siegel, Robert D., Fung, Eric T., Jamshidi, Arash, Aravanis, Alex, Hartman, Anne-Renee, Liu, Minetta C., Klein, Eric A.

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Inter-tumoral heterogeneity of CD3+ and CD8+ T-cell densities in the microenvironment of DNA mismatch repair-deficient colon cancers: implications for prognosis von Yoon, Harry H., Shi, Qian, Heying, Erica N., Muranyi, Andrea, Bredno, Joerg, Ough, Faith, Djalilvand, Azita, Clements, June, Bowermaster, Rebecca, Liu, Wen-Wei, Barnes, Michael, Alberts, Steven R., Shanmugam, Kandavel, Sinicrope, Frank A.

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Abstract 1600: Expanded multiplexing capability in brightfield immunohistochemistry utilizing multiple chromogen chemistries and detection enzymes von Roberts, Esteban, Day, William, Kelly, Brian D., Polaske, Nathan W., Ashworth-Sharpe, Julia, Johnson, Donald, Lefever, Mark, Kosmeder, Jerry, Zhang, Hongjun, Zhang, Jian, Tsao, Tsu-Shuen, Farrell, Mike, Bredno, Joerg, Ochs, Robert, Morrison, Larry

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Genome-wide cell-free DNA (cfDNA) methylation signatures and effect on tissue of origin (TOO) performance von Liu, Minetta C., Jamshidi, Arash, Venn, Oliver, Fields, Alexander P., Maher, M. Cyrus, Cann, Gordon, Amini, Hamed, Gross, Samuel, Bredno, Joerg, Miller, Meredith, Schellenberger, Jan, Kurtzman, Kathryn N., Fung, Eric T., Maddala, Tara, Oxnard, Geoffrey R., Klein, Eric A., Spigel, David R., Hartman, Anne-Renee, Aravanis, Alex, Seiden, Michael

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Validation of In Vivo Magnetic Resonance Imaging Blood-Brain Barrier Permeability Measurements by Comparison With Gold Standard Histology von HOFFMANN, Angelika, BREDNO, Jörg, WENDLAND, Michael F, DERUGIN, Nikita, HOM, Jason, SCHUSTER, Tibor, HUA SU, OHARA, Peter T, YOUNG, William L, WINTERMARK, Max

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Effects of tissue plasminogen activator timing on blood–brain barrier permeability and hemorrhagic transformation in rats with transient ischemic stroke von Zhang, Yanrong, Wang, Yi, Zuo, Zhiyi, Wang, Zhongxing, Roy, Jack, Hou, Qinghua, Tong, Elizabeth, Hoffmann, Angelika, Sperberg, Emily, Bredno, Joerg, Berr, Stuart S, Xie, Mingxing, Lee, Kevin, Wintermark, Max

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P2.01-043 Pathologist Agreement Rates of PD-L1 Tumor and Immune Cell Quantitation Using Digital Read, Field-Of-View, and Whole Tumor Image Analysis von Barnes, Michael, Bai, Isaac, Nguyen, Kien, Bredno, Joerg, Vennapusa, Bharathi, Fonstad, Rachel, Agarwal, Suresh, Patil, Suhas, Little, Elizabeth, Koeppen, Hartmut, Guetter, Christoph

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Quantitative image analysis of PD-L1, CD8, CD3, CD68 and FoxP3 protein expression in lung and bladder cancer specimens by fully automated multiplex fluorescence immunohistochemistr... von Zhang, Wenjun, Khojasteh, Mehrnoush, Cummins, Nick, Hubbard, Antony, Hurley, John, Zhang, Liping, Elgabry, Ehab, Bredno, Joerg, Harshman, Dustin, Day, William, Kowanetz, Marcin, Mariathasan, Sanjeev, Smith, Dustin, Williams, J. Andrew, Pestic-Dragovich, Lidija, Morrison, Larry E., Tang, Lei

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Automated versus manual post-processing of perfusion-CT data in patients with acute cerebral ischemia: influence on interobserver variability von Soares, Bruno P., Dankbaar, Jan Willem, Bredno, Joerg, Cheng, SuChun, Bhogal, Sumail, Dillon, William P., Wintermark, Max

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