Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands von Ferri, Elena, Le Thomas, Adrien, Wallweber, Heidi Ackerly, Day, Eric S., Walters, Benjamin T., Kaufman, Susan E., Braun, Marie-Gabrielle, Clark, Kevin R., Beresini, Maureen H., Mortara, Kyle, Chen, Yung-Chia A., Canter, Breanna, Phung, Wilson, Liu, Peter S., Lammens, Alfred, Ashkenazi, Avi, Rudolph, Joachim, Wang, Weiru

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Carbofluorination via a palladium-catalyzed cascade reaction von Braun, Marie-Gabrielle, Katcher, Matthew H, Doyle, Abigail G

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Introduction of Trifluoroethylamine as Amide Isostere by C–H Functionalization of Heteroarenes von Braun, Marie-Gabrielle, Castanedo, Georgette, Qin, Ling, Salvo, Patrick, Zard, Samir Z

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Palladium-Catalyzed Allylic C–H Fluorination von Braun, Marie-Gabrielle, Doyle, Abigail G

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Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase von Pantua, Homer, Skippington, Elizabeth, Braun, Marie-Gabrielle, Noland, Cameron L., Diao, Jingyu, Peng, Yutian, Gloor, Susan L., Yan, Donghong, Kang, Ling, Katakam, Anand Kumar, Reeder, Janina, Castanedo, Georgette M., Garland, Keira, Komuves, Laszlo, Sagolla, Meredith, Austin, Cary D., Murray, Jeremy, Xu, Yiming, Modrusan, Zora, Xu, Min, Hanan, Emily J., Kapadia, Sharookh B.

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A Highly Stereoselective, Modular Route to (E)-Vinylsulfones and to (Z)- and (E)-Alkenes von Braun, Marie-Gabrielle, Quiclet-Sire, Béatrice, Zard, Samir Z

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Tri- and Tetrasubstituted Functionalized Vinyl Sulfides by Radical Allylation von Debien, Laurent, Braun, Marie-Gabrielle, Quiclet-Sire, Béatrice, Zard, Samir Z

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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα von Hanan, Emily J., Braun, Marie-Gabrielle, Heald, Robert A., MacLeod, Calum, Chan, Connie, Clausen, Saundra, Edgar, Kyle A., Eigenbrot, Charles, Elliott, Richard, Endres, Nicholas, Friedman, Lori S., Gogol, Emily, Gu, Xiao-Hui, Thibodeau, Rebecca Hong, Jackson, Philip S., Kiefer, James R., Knight, Jamie D., Nannini, Michelle, Narukulla, Raman, Pace, Amanda, Pang, Jodie, Purkey, Hans E., Salphati, Laurent, Sampath, Deepak, Schmidt, Stephen, Sideris, Steve, Song, Kyung, Sujatha-Bhaskar, Swathi, Ultsch, Mark, Wallweber, Heidi, Xin, Jianfeng, Yeap, SiewKuen, Young, Amy, Zhong, Yu, Staben, Steven T.

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Disruption of IRE1α through its kinase domain attenuates multiple myeloma von Harnoss, Jonathan M., Le Thomas, Adrien, Shemorry, Anna, Marsters, Scot A., Lawrence, David A., Lu, Min, Chen, Yung-Chia Ariel, Qing, Jing, Totpal, Klara, Kan, David, Segal, Ehud, Merchant, Mark, Reichelt, Mike, Wallweber, Heidi Ackerly, Wang, Weiru, Clark, Kevin, Kaufman, Susan, Beresini, Maureen H., Laing, Steven T., Sandoval, Wendy, Lorenzo, Maria, Wu, Jiansheng, Ly, Justin, De Bruyn, Tom, Heidersbach, Amy, Haley, Benjamin, Gogineni, Alvin, Weimer, Robby M., Lee, Dong, Braun, Marie-Gabrielle, Rudolph, Joachim, VanWyngarden, Michael J., Sherbenou, Daniel W., Gomez-Bougie, Patricia, Amiot, Martine, Acosta-Alvear, Diego, Walter, Peter, Ashkenazi, Avi

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Synthesis of Fused Imidazole-Containing Ring Systems via Dual Oxidative Amination of C(sp3)–H Bonds von Castanedo, Georgette, Liu, Yanzhou, Crawford, James J, Braun, Marie-Gabrielle

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Discovery of Potent, Selective, and Orally Available IRE1α Inhibitors Demonstrating Comparable PD Modulation to IRE1 Knockdown in a Multiple Myeloma Model von Braun, Marie-Gabrielle, Ashkenazi, Avi, Beveridge, Ramsay E., Castanedo, Georgette, Wallweber, Heidi Ackerly, Beresini, Maureen H., Clark, Kevin R., De Bruyn, Tom, Fu, Liqiang, Gibbons, Paul, Jiang, Fan, Kaufman, Susan, Kan, David, Kiefer, James R., Leclerc, Jean-Philippe, Lemire, Alexandre, Ly, Cuong, Segal, Ehud, Sims, Jessica, Wang, Weiru, Wei, Wentao, Zhao, Liang, Schwarz, Jacob B., Rudolph, Joachim

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Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation von Dorel, Ruth, Sun, Dawei, Carruthers, Nicholas, Castanedo, Georgette M., Ung, Peter M.-U., Factor, Daniel C., Li, Tianbo, Baumann, Hannah, Janota, Danielle, Pang, Jodie, Salphati, Laurent, Meklemburg, Robert, Korman, Allison J., Harper, Halie E., Stubblefield, Samantha, Payandeh, Jian, McHugh, Daniel, Lang, Bradley T., Tesar, Paul J., Dere, Edward, Masureel, Matthieu, Adams, Drew J., Volgraf, Matthew, Braun, Marie-Gabrielle

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Optimization of globomycin analogs as novel gram-negative antibiotics von Garland, Keira, Pantua, Homer, Braun, Marie-Gabrielle, Burdick, Daniel J., Castanedo, Georgette M., Chen, Yi-Chen, Cheng, Yun-Xing, Cheong, Jonathan, Daniels, Blake, Deshmukh, Gauri, Fu, Yuhong, Gibbons, Paul, Gloor, Susan L., Hua, Rongbao, Labadie, Sharada, Liu, Xiongcai, Pastor, Richard, Stivala, Craig, Xu, Min, Xu, Yiming, Zheng, Hao, Kapadia, Sharookh B., Hanan, Emily J.

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Green Chemistry Articles of Interest to the Pharmaceutical Industry von Braun, Marie-Gabrielle, Diorazio, Louis, Fraunhoffer, Kenneth, Hayler, John, Hickey, Matthew, Latham, Jonathan, Lovelle, Lucie E, McLaws, Mark, Parsons, Andrew T, Richardson, Paul, Roiban, Gheorghe-Doru, Roosen, Philipp C, Steven, Alan, Terrett, Jack A, White, Timothy, Yin, Jingjun

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Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1α Inhibitory Activity von Beveridge, Ramsay E, Wallweber, Heidi Ackerly, Ashkenazi, Avi, Beresini, Maureen, Clark, Kevin R, Gibbons, Paul, Ghiro, Elise, Kaufman, Susan, Larivée, Alexandre, Leblanc, Melissa, Leclerc, Jean-Philippe, Lemire, Alexandre, Ly, Cuong, Rudolph, Joachim, Schwarz, Jacob B, Srivastava, Sanjay, Wang, Weiru, Zhao, Liang, Braun, Marie-Gabrielle

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Green Chemistry Articles of Interest to the Pharmaceutical Industry von Braun, Marie-Gabrielle, Díaz-Rodríguez, Alba, Diorazio, Louis, Fei, Zhongbo, Fraunhoffer, Kenneth, Hayler, John, Hickey, Matthew, McLaws, Mark, Richardson, Paul, Roiban, Gheorghe-Doru, Parsons, Andrew T, Steven, Alan, Terrett, Jack, White, Timothy, Yin, Jingjun

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An Approach to α-Keto Vinyl Carbinols von Braun, Marie-Gabrielle, Zard, Samir Z

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Green Chemistry Articles of Interest to the Pharmaceutical Industry von Braun, Marie-Gabrielle, Díaz-Rodríguez, Alba, Diorazio, Louis, Fei, Zhongbo, Fraunhoffer, Kenneth, Hayler, John, Hickey, Matthew, Hughes, Shaun, McLaws, Mark, Richardson, Paul, Schober, Markus, Smith, Austin G, Steven, Alan, Terrett, Jack, White, Timothy, Yin, Jingjun

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Transfer of Chirality by the Use of an All Carbon Tether von Braun, Marie-Gabrielle, Heng, Rama, Zard, Samir Z

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Preclinical development of the PI3K Alpha selective and PIK3CA Mutant selective inhibitor GDC-0077 and prediction of its human pharmacokinetics von Pang, Jodie, Baumgardner, Matthew, Braun, Marie-Gabrielle, Cheong, Jonathan, Edgar, Kyle, Friedman, Lori, Hanan, Emily, Jaochico, Allan, Ma, Shuguang, Plise, Emile, Schmidt, Stephen, Liu, Ning, Song, Kyung, Staben, Steve, Salphati, Laurent

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