Cloning the Soil Metagenome: a Strategy for Accessing the Genetic and Functional Diversity of Uncultured Microorganisms von RONDON, M. R, AUGUST, P. R, CHOI LAI TIONG, GILMAN, M, OSBURNE, M. S, CLARDY, J, HANDELSMAN, J, GOODMAN, R. M, BETTERMANN, A. D, BRADY, S. F, GROSSMAN, T. H, LILES, M. R, LOIACONO, K. A, LYNCH, B. A, MACNEIL, I. A, MINOR, C

Volltext

The Guanacastepenes:  A Highly Diverse Family of Secondary Metabolites Produced by an Endophytic Fungus von Brady, Sean F, Bondi, Shana M, Clardy, Jon

Volltext

Biological Activity of Guanacastepene, a Novel Diterpenoid Antibiotic Produced by an Unidentified Fungus CR115 von SINGH, M. P., JANSO, J. E., LUCKMAN, S. W., BRADY, S. F., CLARDY, J., GREENSTEIN, M., MAIESE, W. M.

Volltext

Isolation of Antibiotics Turbomycin A and B from a Metagenomic Library of Soil Microbial DNA von GILLESPIE, Doreen E, BRADY, Sean F, BETTERMANN, Alan D, CIANCIOTTO, Nicholas P, LILES, Mark R, RONDON, Michelle R, CLARDY, Jon, GOODMAN, Robert M, HANDELSMAN, Jo

Volltext

Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position von Tucker, Thomas J, Brady, Stephen F, Lumma, William C, Lewis, S. Dale, Gardell, Stephen J, Naylor-Olsen, Adel M, Yan, Youwei, Sisko, Jack T, Stauffer, Kenneth J, Lucas, Bobby J, Lynch, Joseph J, Cook, Jacquelynn J, Stranieri, Maria T, Holahan, Marie A, Lyle, Elizabeth A, Baskin, Elizabeth P, Chen, I-Wu, Dancheck, Kimberly B, Krueger, Julie A, Cooper, Carolyn M, Vacca, Joseph P

Volltext

Design of Novel, Potent, Noncovalent Inhibitors of Thrombin with Nonbasic P-1 Substructures:  Rapid Structure−Activity Studies by Solid-Phase Synthesis von Lumma, William C, Witherup, Keith M, Tucker, Thomas J, Brady, Steven F, Sisko, John T, Naylor-Olsen, Adel M, Lewis, S. Dale, Lucas, Bobby J, Vacca, Joseph P

Volltext

New Natural Product Families from an Environmental DNA (eDNA) Gene Cluster von Brady, Sean F, Chao, Carol J, Clardy, Jon

Volltext

Cloning and Heterologous Expression of a Natural Product Biosynthetic Gene Cluster from eDNA von Brady, Sean F, Chao, Carol J, Handelsman, Jo, Clardy, Jon

Volltext

Long-Chain N-Acyl Amino Acid Antibiotics Isolated from Heterologously Expressed Environmental DNA von Brady, Sean F, Clardy, Jon

Volltext

Pantocin B, an Antibiotic from Erwinia herbicola Discovered by Heterologous Expression of Cloned Genes von Brady, Sean F, Wright, Sandra A, Lee, Julie C, Sutton, Amanda E, Zumoff, Cathy H, Wodzinski, Richard S, Beer, Steven V, Clardy, Jon

Volltext

Palmitoylputrescine, an Antibiotic Isolated from the Heterologous Expression of DNA Extracted from Bromeliad Tank Water von Brady, Sean F, Clardy, Jon

Volltext

Discovery and Development of the Novel Potent Orally Active Thrombin Inhibitor N-(9-Hydroxy-9-fluorenecarboxy)prolyl trans-4-Aminocyclohexylmethyl Amide (L-372,460):  Coapplication... von Brady, Stephen F, Stauffer, Kenneth J, Lumma, William C, Smith, Graham M, Ramjit, Harri G, Lewis, S. Dale, Lucas, Bobby J, Gardell, Steven J, Lyle, Elizabeth A, Appleby, Sandra D, Cook, Jacquelynn J, Holahan, Marie A, Stranieri, Maria T, Lynch, Joseph J, Lin, Jiunn H, Chen, I.-Wu, Vastag, Kari, Naylor-Olsen, Adel M, Vacca, Joseph P

Volltext

The Cytosporones, New Octaketide Antibiotics Isolated from an Endophytic Fungus von Brady, Sean F, Wagenaar, Melissa M, Singh, Maya P, Janso, Jeff E, Clardy, Jon

Volltext

HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins von Darke, Paul L., Nutt, Ruth F., Brady, Stephen F., Garsky, Victor M., Ciccarone, Terrence M., Leu, Chih-Tai, Lumma, Patricia K., Freidinger, Roger M., Veber, Daniel F., Sigal, Irving S.

Volltext

Amino Acid Sequence of Homologous Rat Atrial Peptides: Natriuretic Activity of Native and Synthetic Forms von Seidah, N. G., Lazure, C., Chrétien, M., Thibault, G., Garcia, R., Cantin, M., Genest, J., Nutt, R. F., Brady, S. F., Lyle, T. A., Paleveda, W. J., Colton, C. D., Ciccarone, T. M., Veber, D. F.

Volltext

Chemical Synthesis and Enzymatic Activity of a 99-Residue Peptide with a Sequence Proposed for the Human Immunodeficiency Virus Protease von Nutt, Ruth F., Brady, Stephen F., Darke, Paul L., Ciccarone, Terrence M., Colton, C. Dylion, Nutt, Elka M., Rodkey, John A., Bennett, Carl D., Waxman, Lloyd H., Sigal, Irving S., Anderson, Paul S., Veber, Daniel F.

Volltext

Cytoskyrins A and B, New BIA Active Bisanthraquinones Isolated from an Endophytic Fungus von Brady, Sean F, Singh, Maya P, Janso, Jeff E, Clardy, Jon

Volltext

A super active cyclic hexapeptide analog of somatostatin von Veber, Daniel F., Saperstein, Richard, Nutt, Ruth F., Freidinger, Roger M., Brady, Stephen F., Curley, Paul, Perlow, Debra S., Paleveda, William J., Colton, C.Dylion, Zacchei, Anthony G., Tocco, Dominick J., Hoff, Dale R., Vandlen, Richard L., Gerich, John E., Hall, Larry, Mandarino, Lawrence, Cordes, Eugene H., Anderson, Paul S., Hirschmann, Ralph

Volltext

The solution conformation Ac-Pen-Arg-Gly-Asp-Cys-OH, a potent fibrinogen receptor antagonist von Bogusky, Michael J., Naylor, Adel M., Mertzman, Michael E., Pitzenberger, Steven M., Nutt, Ruth F., Brady, Stephen F., Colton, Christiane D., Veber, Daniel F.

Volltext

NMR and molecular modeling characterization of RGD containing peptides von BOGUSKY, M.J., NAYLOR, A.M., PITZENBERGER, S.M., NUTT, R.F., BRADY, S.F., COLTON, C.D., SISKO, J.T., ANDERSON, P.S., VEBER, D.F.

Volltext