Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas von Chung, Chan, Sweha, Stefan R., Pratt, Drew, Tamrazi, Benita, Panwalkar, Pooja, Banda, Adam, Bayliss, Jill, Hawes, Debra, Yang, Fusheng, Lee, Ho-Joon, Shan, Mengrou, Cieslik, Marcin, Qin, Tingting, Werner, Christian K., Wahl, Daniel R., Lyssiotis, Costas A., Bian, Zhiguo, Shotwell, J. Brad, Yadav, Viveka Nand, Koschmann, Carl, Chinnaiyan, Arul M., Blüml, Stefan, Judkins, Alexander R., Venneti, Sriram

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Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315 von Jakob, Clarissa G, Upadhyay, Anup K, Donner, Pamela L, Nicholl, Emily, Addo, Sadiya N, Qiu, Wei, Ling, Christopher, Gopalakrishnan, Sujatha M, Torrent, Maricel, Cepa, Steven P, Shanley, Jason, Shoemaker, Alexander R, Sun, Chaohong C, Vasudevan, Anil, Woller, Kevin R, Shotwell, J. Brad, Shaw, Bailin, Bian, Zhiguo, Hutti, Jessica E

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Design of N‑Benzoxaborole Benzofuran GSK8175Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor von Chong, Pek Y, Shotwell, J. Brad, Miller, John, Price, Daniel J, Maynard, Andy, Voitenleitner, Christian, Mathis, Amanda, Williams, Shawn, Pouliot, Jeffrey J, Creech, Katrina, Wang, Feng, Fang, Jing, Zhang, Huichang, Tai, Vincent W.-F, Turner, Elizabeth, Kahler, Kirsten M, Crosby, Renae, Peat, Andrew J

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The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors von Wood, Edgar R., Bledsoe, Randy, Chai, Jing, Daka, Philias, Deng, Hongfeng, Ding, Yun, Harris-Gurley, Sarah, Kryn, Luz Helena, Nartey, Eldridge, Nichols, James, Nolte, Robert T., Prabhu, Ninad, Rise, Cecil, Sheahan, Timothy, Shotwell, J. Brad, Smith, Danielle, Tai, Vince, Taylor, J. David, Tomberlin, Ginger, Wang, Liping, Wisely, Bruce, You, Shihyun, Xia, Bing, Dickson, Hamilton

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Discovery of Selective Small Molecule Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα) Inhibitors as Anti Hepatitis C (HCV) Agents von Leivers, Anna L., Tallant, Matthew, Shotwell, J. Brad, Dickerson, Scott, Leivers, Martin R., McDonald, Octerloney B., Gobel, Jeff, Creech, Katrina L., Strum, Susan L., Mathis, Amanda, Rogers, Sabrinia, Moore, Chris B., Botyanszki, Janos

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GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers von Sabbatini, Peter, Korenchuk, Susan, Rowand, Jason L, Groy, Arthur, Liu, Qi, Leperi, Dominic, Atkins, Charity, Dumble, Melissa, Yang, Jingsong, Anderson, Kelly, Kruger, Ryan G, Gontarek, Richard R, Maksimchuk, Kenneth R, Suravajjala, Sapna, Lapierre, Russell R, Shotwell, J Brad, Wilson, Joseph W, Chamberlain, Stanley D, Rabindran, Sridhar K, Kumar, Rakesh

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In Vitro Characterization of GSK2485852, a Novel Hepatitis C Virus Polymerase Inhibitor von VOITENLEITNER, Christian, CROSBY, Renae, HORTON, Joseph, CREECH, Katrina, SHOTWELL, J. Brad, ZHI HONG, HAMATAKE, Robert, WALKER, Jill, REMLINGER, Katja, VAMATHEVAN, Jessica, WANG, Amy, SHIHYUN YOU, JOHNSON, John, WOLDU, Ermias, VAN HORN, Stephanie

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Synthesis of the C11−C29 Fragment of Amphidinolide F von Shotwell, J. Brad, Roush, William R

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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity von Chamberlain, Stanley D, Redman, Anikó M, Wilson, Joseph W, Deanda, Felix, Shotwell, J Brad, Gerding, Roseanne, Lei, Huangshu, Yang, Bin, Stevens, Kirk L, Hassell, Anne M, Shewchuk, Lisa M, Leesnitzer, M Anthony, Smith, Jeffery L, Sabbatini, Peter, Atkins, Charity, Groy, Arthur, Rowand, Jason L, Kumar, Rakesh, Mook, Jr, Robert A, Moorthy, Ganesh, Patnaik, Samarjit

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Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway von CHAMBERLAIN, Stanley D, REDMAN, Aniko M, STEVENS, Kirk L, WILSON, Joseph W, BRAD SHOTWELL, J, PATNAIK, Samarjit, BRICKHOUSE, Keith, CHEW, Yen-Chiat, DEANDA, Felix, GERDING, Roseanne, HUANGSHU LEI, MOORTHY, Ganesh, PATRICK, Mark

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Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis von Todorović, Viktor, Su, Zhi, Putman, C. Brent, Kakavas, Stevan J., Salte, Katherine M., McDonald, Heath A., Wetter, Joseph B., Paulsboe, Stephanie E., Sun, Qi, Gerstein, Clare E., Medina, Limary, Sielaff, Bernhard, Sadhukhan, Ramkrishna, Stockmann, Henning, Richardson, Paul L., Qiu, Wei, Argiriadi, Maria A., Henry, Rodger F., Herold, J. Martin, Shotwell, J. Brad, McGaraughty, Steve P., Honore, Prisca, Gopalakrishnan, Sujatha M., Sun, Chaohong C., Scott, Victoria E.

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The HPK1 Inhibitor A‑745 Verifies the Potential of Modulating T Cell Kinase Signaling for Immunotherapy von Malchow, Sven, Korepanova, Alla, Panchal, Sanjay C, McClure, Ryan A, Longenecker, Kenton L, Qiu, Wei, Zhao, Hongyu, Cheng, Min, Guo, Jun, Klinge, Kelly L, Trusk, Patricia, Pratt, Steven D, Li, Tao, Kurnick, Matthew D, Duan, Lishu, Shoemaker, Alex R, Gopalakrishnan, Sujatha M, Warder, Scott E, Shotwell, J. Brad, Lai, Albert, Sun, Chaohong, Osuma, Augustine T, Pappano, William N

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Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase von CHAMBERLAIN, Stanley D, WILSON, Joseph W, ATKINS, Charity, GERDING, Roseanne, HASSELL, Anne M, HUANGSHU LEI, MOCK, Robert A, MOORTHY, Ganesh, ROWAND, Jason L, STEVENS, Kirk L, KUMAR, Rakesh, BRAD SHOTWELL, J, DEANDA, Felix, PATNAIK, Samarjit, REDMAN, Aniko M, BIN YANG, SHEWCHUK, Lisa, SABBATINI, Peter, LEESNITZER, M. Anthony, GROY, Arthur

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Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines von Chamberlain, Stanley D, Gerding, Roseanne M, Lei, Huangshu, Moorthy, Ganesh, Patnaik, Samarjit, Redman, Anikó M, Stevens, Kirk L, Wilson, Joseph W, Yang, Bin, Shotwell, J. Brad

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Structure and Energetics of the Samarium Diiodide−HMPA Complex in Tetrahydrofuran von Shotwell, J. Brad, Sealy, Jennifer M, Flowers, Robert A

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Stereoselective Syntheses of the C(1)−C(9) Fragment of Amphidinolide C von Bates, Robert H, Shotwell, J. Brad, Roush, William R

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Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase von Maynard, Andrew, Crosby, Renae M., Ellis, Byron, Hamatake, Robert, Hong, Zhi, Johns, Brian A., Kahler, Kirsten M., Koble, Cecilia, Leivers, Anna, Leivers, Martin R., Mathis, Amanda, Peat, Andrew J., Pouliot, Jeffrey J., Roberts, Christopher D., Samano, Vicente, Schmidt, Rachel M., Smith, Gary K., Spaltenstein, Andrew, Stewart, Eugene L., Thommes, Pia, Turner, Elizabeth M., Voitenleitner, Christian, Walker, Jill T., Waitt, Greg, Weatherhead, Jason, Weaver, Kurt, Williams, Shawn, Wright, Lois, Xiong, Zhiping Z., Haigh, David, Shotwell, J. Brad

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Hepatitis C Replication Inhibitors That Target the Viral NS4B Protein von Miller, John F., Chong, Pek Y., Shotwell, J. Brad, Catalano, John G., Tai, Vincent W.-F., Fang, Jing, Banka, Anna L., Roberts, Christopher D., Youngman, Michael, Zhang, Huichang, Xiong, Zhiping, Mathis, Amanda, Pouliot, Jeffery J., Hamatake, Robert K., Price, Daniel J., Seal, John W., Stroup, Lisa L., Creech, Katrina L., Carballo, Luz H., Todd, Dan, Spaltenstein, Andrew, Furst, Sylvia, Hong, Zhi, Peat, Andrew J.

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Efficient Construction of the Securine A Carbon Skeleton von Korakas, Peter, Chaffee, Stuart, Shotwell, J. Brad, Duque, Pamela, Wood, John L., Nicolaou, Kyriacos C.

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Georgia marble at the Minnesota State Capitol The Effects of Mineralogy and Climate on Durability von Whitenack, Paul, Shotwell, L. Brad, Scheffler, Michael J.

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