Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer von O’Connell, James, Porter, John, Kroeplien, Boris, Norman, Tim, Rapecki, Stephen, Davis, Rachel, McMillan, David, Arakaki, Tracy, Burgin, Alex, Fox III, David, Ceska, Tom, Lecomte, Fabien, Maloney, Alison, Vugler, Alex, Carrington, Bruce, Cossins, Benjamin P, Bourne, Tim, Lawson, Alastair

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Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF von McMillan, David, Martinez-Fleites, Carlos, Porter, John, Fox, David, Davis, Rachel, Mori, Prashant, Ceska, Tom, Carrington, Bruce, Lawson, Alastair, Bourne, Tim, O’Connell, James

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A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF von Lightwood, Daniel J., Munro, Rebecca J., Porter, John, McMillan, David, Carrington, Bruce, Turner, Alison, Scott-Tucker, Anthony, Hickford, Elizabeth S., Schmidt, Antje, Fox, David, Maloney, Alison, Ceska, Tom, Bourne, Tim, O’Connell, James, Lawson, Alastair D. G.

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Efficacy of an Inhaled IL-13 Antibody Fragment in a Model of Chronic Asthma von Lightwood, Daniel, Tservistas, Markus, Zehentleitner, Monique, Sarkar, Kaushik, Turner, Alison, Bracher, Marguerite, Smith, Bryan, Lamour, Sabrina, Bourne, Tim, Shaw, Stevan, Gozzard, Neil, Palframan, Roger T

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Transitioning EPMA applications in a large multisite teaching hospital von Silva, Geeth, Hall, Graeme, Vogel, Aaron, Bourne, Tim, Xu, Gang

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An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis von Vugler, Alexander, O'Connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Ying, Xiaoyou, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicholas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Zhu, Zhaoning, Brookings, Daniel, Horsley, Helen, Heer, Jag, Schio, Laurent, Herrmann, Matthias, Rao, Srinivas, Kohlmann, Markus, Florian, Peter

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Corrigendum: An orally available small molecule that targets soluble TNF to deliver anti-TNF biologic-like efficacy in rheumatoid arthritis von Vugler, Alexander, O'connell, James, Nguyen, Mai Anh, Weitz, Dietmar, Leeuw, Thomas, Hickford, Elizabeth, Verbitsky, Alexander, Ying, Xiaoyou, Rehberg, Markus, Carrington, Bruce, Merriman, Mark, Moss, Andrew, Nicolas, Jean-Marie, Stanley, Phil, Wright, Sara, Bourne, Tim, Foricher, Yann, Zhu, Zhaoning, Brookings, Daniel, Horsley, Helen, Heer, Jag, Schio, Laurent, Herrmann, Matthias, Rao, Srinivas, Kohlmann, Markus, Florian, Peter

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Codeveloping an effective EMPA to maturity in an acute NHS Trust: an implementer report von Silva, Geeth, Bourne, Tim, Hall, Graeme, Patel, Shriyam, Rauf, Mohammed Qasim, Vogel, Aaron, Carruthers, Andrew, Xu, Gang

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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function von Sugiura, Ayaka, Andrejeva, Gabriela, Voss, Kelsey, Heintzman, Darren R., Xu, Xincheng, Madden, Matthew Z., Ye, Xiang, Beier, Katherine L., Chowdhury, Nowrin U., Wolf, Melissa M., Young, Arissa C., Greenwood, Dalton L., Sewell, Allison E., Shahi, Shailesh K., Freedman, Samantha N., Cameron, Alanna M., Foerch, Patrik, Bourne, Tim, Garcia-Canaveras, Juan C., Karijolich, John, Newcomb, Dawn C., Mangalam, Ashutosh K., Rabinowitz, Joshua D., Rathmell, Jeffrey C.

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Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti‐tumor necrosis factor α agents von Nesbitt, Andrew, Fossati, Gianluca, Bergin, Marianne, Stephens, Paul, Stephens, Sue, Foulkes, Roly, Brown, Derek, Robinson, Martyn, Bourne, Tim

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Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti-tumor necrosis factor a agents von Nesbitt, Andrew, Fossati, Gianluca, Bergin, Marianne, Stephens, Paul, Stephens, Sue, Foulkes, Roly, Brown, Derek, Robinson, Martyn, Bourne, Tim

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Essential role for CD103 in the T cell-mediated regulation of experimental colitis von Annacker, Oliver, Coombes, Janine L, Malmstrom, Vivianne, Uhlig, Holm H, Bourne, Tim, Johansson-Lindbom, Bengt, Agace, William W, Parker, Christina M, Powrie, Fiona

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The Use of Surrogate Antibodies to Evaluate the Developmental and Reproductive Toxicity Potential of an Anti-TNFα PEGylated Fab′ Monoclonal Antibody von Wakefield, Ian, Stephens, Sue, Foulkes, Roly, Nesbitt, Andrew, Bourne, Tim

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Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling von Shaw, Stevan, Bourne, Tim, Meier, Chris, Carrington, Bruce, Gelinas, Rich, Henry, Alistair, Popplewell, Andrew, Adams, Ralph, Baker, Terry, Rapecki, Steve, Marshall, Diane, Moore, Adrian, Neale, Helen, Lawson, Alastair

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A PEGylated Fab’ Fragment against Tumor Necrosis Factor for the Treatment of Crohn Disease: Exploring a New Mechanism of Action von Bourne, Tim, Fossati, Gianluca, Nesbitt, Andrew

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Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation von Minet, Norbert, Boschat, Anne-Claire, Lane, Rebecca, Laughton, David, Beer, Philip, Asnagli, Hélène, Soudais, Claire, Bourne, Tim, Fischer, Alain, Martin, Emmanuel, Latour, Sylvain

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Target occupancy biomarker assay development using a conformation-selective antibody against small-molecule-bound TNF von Hickford, Elizabeth S, O'Connell, James, Maloney, Alison, Florian, Peter, Johnston, Geoffrey I, Rospo, Chiara Carla, Herrmann, Matthias, Wright, Sara, Bourne, Tim

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Impaired lymphocyte function and differentiation in CTPS1-deficient patients result from a hypomorphic homozygous mutation von Martin, Emmanuel, Minet, Norbert, Boschat, Anne-Claire, Sanquer, Sylvia, Sobrino, Steicy, Lenoir, Christelle, de Villartay, Jean Pierre, Leite-de-Moraes, Maria, Picard, Capucine, Soudais, Claire, Bourne, Tim, Hambleton, Sophie, Hughes, Stephen M, Wynn, Robert F, Briggs, Tracy A, Patel, Smita, Lawrence, Monica G, Fischer, Alain, Arkwright, Peter D, Latour, Sylvain

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The Discovery, Engineering and Characterisation of a Highly Potent Anti-Human IL-13 Fab Fragment Designed for Administration by Inhalation von Lightwood, Daniel, O'Dowd, Victoria, Carrington, Bruce, Veverka, Vaclav, Carr, Mark D., Tservistas, Markus, Henry, Alistair J., Smith, Bryan, Tyson, Kerry, Lamour, Sabrina, Sarkar, Kaushik, Turner, Alison, Lawson, Alastair D., Bourne, Tim, Gozzard, Neil, Palframan, Roger

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Collagen II antibody-induced arthritis in Tg1278TNFko mice: optimization of a novel model to assess treatments targeting human TNFα in rheumatoid arthritis von Moore, Adrian Richard, Allden, Sarah, Bourne, Tim, Denis, Maria C, Kranidioti, Ksanthi, Okoye, Remi, Sotsios, Yannis, Stencel, Zofia, Vugler, Alexander, Watt, Gillian, Shaw, Stevan

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