Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease von Bourbeau, Matthew P, Bartberger, Michael D

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Discovery of Clinical Candidate 1‑(4-(3-(4-(1H‑Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor o... von Hu, Essa, Chen, Ning, Bourbeau, Matthew P, Harrington, Paul E, Biswas, Kaustav, Kunz, Roxanne K, Andrews, Kristin L, Chmait, Samer, Zhao, Xiaoning, Davis, Carl, Ma, Ji, Shi, Jianxia, Lester-Zeiner, Dianna, Danao, Jean, Able, Jessica, Cueva, Madelyn, Talreja, Santosh, Kornecook, Thomas, Chen, Hang, Porter, Amy, Hungate, Randall, Treanor, James, Allen, Jennifer R

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Synthesis of Enantioenriched Propargylic Alcohols Related to Polyketide Natural Products. A Comparison of Methodologies von Marshall, James A, Bourbeau, Matthew P

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Nonracemic Synthesis of GK–GKRP Disruptor AMG-3969 von Bourbeau, Matthew P, Ashton, Kate S, Yan, Jie, St. Jean, David J

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The optimization of aminooxadiazoles as orally active inhibitors of Cdc7 von Harrington, Paul E., Bourbeau, Matthew P., Fotsch, Christopher, Frohn, Michael, Pickrell, Alexander J., Reichelt, Andreas, Sham, Kelvin, Siegmund, Aaron C., Bailis, Julie M., Bush, Tammy, Escobar, Sonia, Hickman, Dean, Heller, Scott, Hsieh, Faye, Orf, Jessica N., Rong, Minqing, San Miguel, Tisha, Tan, Helming, Zalameda, Leeanne, Allen, John G.

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Discovery of AM-6494: A Potent and Orally Efficacious β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2 von Pettus, Liping H, Bourbeau, Matthew P, Bradley, Jodi, Bartberger, Michael D, Chen, Kui, Hickman, Dean, Johnson, Michael, Liu, Qingyian, Manning, James R, Nanez, Adrian, Siegmund, Aaron C, Wen, Paul H, Whittington, Douglas A, Allen, Jennifer R, Wood, Stephen

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Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe von Tamayo, Nuria A, Bourbeau, Matthew P, Allen, Jennifer R, Ashton, Kate S, Chen, Jian Jeffrey, Kaller, Matthew R, Nguyen, Thomas T, Nishimura, Nobuko, Pettus, Liping H, Walton, Mary, Belmontes, Brian, Moriguchi, Jodi, Chen, Kui, McCarter, John D, Hanestad, Kelly, Chung, Grace, Ninniri, Maria Stefania S, Sun, Jan, Poppe, Leszek, Spahr, Chris, Hui, John, Jia, Lei, Wu, Tian, Dahal, Upendra P, Edson, Katheryne Z, Payton, Marc

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2-Aminothiadiazole inhibitors of AKT1 as potential cancer therapeutics von Zeng, Qingping, Bourbeau, Matthew P., Wohlhieter, G. Erich, Yao, Guomin, Monenschein, Holger, Rider, James T., Lee, Matthew R., Zhang, Shiwen, Lofgren, Julie, Freeman, Daniel, Li, Chun, Tominey, Elizabeth, Huang, Xin, Hoffman, Douglas, Yamane, Harvey, Tasker, Andrew S., Dominguez, Celia, Viswanadhan, Vellarkad N., Hungate, Randall, Zhang, Xiaoling

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The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement von Frohn, Michael, Liu, Longbin, Siegmund, Aaron C., Qian, Wenyuan, Amegadzie, Albert, Chen, Ning, Tan, Helming, Hickman, Dean, Wood, Stephen, Wen, Paul H., Bartberger, Michael D., Whittington, Douglas A., Allen, Jennifer R., Bourbeau, Matthew P.

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Azole-based inhibitors of AKT/PKB for the treatment of cancer von Zeng, Qingping, Allen, John G., Bourbeau, Matthew P., Wang, Xianghong, Yao, Guomin, Tadesse, Seifu, Rider, James T., Yuan, Chester C., Hong, Fang-Tsao, Lee, Matthew R., Zhang, Shiwen, Lofgren, Julie A., Freeman, Daniel J., Yang, Suijin, Li, Chun, Tominey, Elizabeth, Huang, Xin, Hoffman, Douglas, Yamane, Harvey K., Fotsch, Christopher, Dominguez, Celia, Hungate, Randall, Zhang, Xiaoling

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Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2−Tumor Protein 53 Protein−Protein Interaction von Allen, John G, Bourbeau, Matthew P, Wohlhieter, G. Erich, Bartberger, Michael D, Michelsen, Klaus, Hungate, Randall, Gadwood, Robert C, Gaston, Rick D, Evans, Bruce, Mann, Larry W, Matison, Michael E, Schneider, Stephen, Huang, Xin, Yu, Dongyin, Andrews, Paul S, Reichelt, Andreas, Long, Alexander M, Yakowec, Peter, Yang, Evelyn Y, Lee, Tani Ann, Oliner, Jonathan D

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Recent Advances in the Development of Acetyl-CoA Carboxylase (ACC) Inhibitors for the Treatment of Metabolic Disease: Miniperspective von Bourbeau, Matthew P, Bartberger, Michael D

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Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ... von Pennington, Lewis D, Bartberger, Michael D, Croghan, Michael D, Andrews, Kristin L, Ashton, Kate S, Bourbeau, Matthew P, Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Hong, Fang-Tsao, Hungate, Randall W, Jordan, Steven R, Kong, Ke, Liu, Longbin, Michelsen, Klaus, Moyer, Carolyn, Nishimura, Nobuko, Norman, Mark H, Reichelt, Andreas, Siegmund, Aaron C, Sivits, Glenn, Tadesse, Seifu, Tegley, Christopher M, Van, Gwyneth, Yang, Kevin C, Yao, Guomin, Zhang, Jiandong, Lloyd, David J, Hale, Clarence, St. Jean, David J

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A Convenient Synthesis of 4-Alkyl-5-aminoisoxazoles von Bourbeau, Matthew P, Rider, James T

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Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers von Payton, Marc, Belmontes, Brian, Hanestad, Kelly, Moriguchi, Jodi, Chen, Kui, McCarter, John D, Chung, Grace, Ninniri, Maria Stefania, Sun, Jan, Manoukian, Raffi, Chambers, Stuart, Ho, Seok-Man, Kurzeja, Robert J M, Edson, Katheryne Z, Dahal, Upendra P, Wu, Tian, Wannberg, Sharon, Beltran, Pedro J, Canon, Jude, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Minocherhomji, Sheroy, Bourbeau, Matthew P, Allen, Jennifer R, Coxon, Angela, Tamayo, Nuria A, Hughes, Paul E

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Piperazine Oxadiazole Inhibitors of Acetyl-CoA Carboxylase von Bourbeau, Matthew P, Siegmund, Aaron, Allen, John G, Shu, Hong, Fotsch, Christopher, Bartberger, Michael D, Kim, Ki-Won, Komorowski, Renee, Graham, Melissa, Busby, James, Wang, Minghan, Meyer, James, Xu, Yang, Salyers, Kevin, Fielden, Mark, Véniant, Murielle M, Gu, Wei

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Directed Pd(0)-catalyzed hydrostannations of internal alkynes von Marshall, James A, Bourbeau, Matthew P

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Total Synthesis of (−)-Callystatin A von Marshall, James A, Bourbeau, Matthew P

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Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes G... von Subramanian, Raju, Lee, Matthew R, Allen, John G, Bourbeau, Matthew P, Fotsch, Christopher, Hong, Fang-Tsao, Tadesse, Seifu, Yao, Guomin, Yuan, Chester C, Surapaneni, Sekhar, Skiles, Gary L, Wang, Xianghong, Wohlhieter, G. Erich, Zeng, Qingping, Zhou, Yihong, Zhu, Xiaochun, Li, Chun

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Second-Generation Synthesis of the Polypropionate Subunit of Callystatin A Based on Regioselective Internal Alkyne Hydrostannation von Marshall, James A, Bourbeau, Matthew P

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