Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of... von Da-silva, Franck, Boulenc, Xavier, Vermet, Hélène, Compigne, Pauline, Gerbal-Chaloin, Sabine, Daujat-Chavanieu, Martine, Klieber, Sylvie, Poulin, Patrick

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Pharmacokinetic assessment of a five‐probe cocktail for CYPs 1A2, 2C9, 2C19, 2D6 and 3A von Turpault, Sandrine, Brian, William, Van Horn, Robert, Santoni, Alix, Poitiers, Franck, Donazzolo, Yves, Boulenc, Xavier

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Effects of omeprazole and genetic polymorphism of CYP2C19 on the clopidogrel active metabolite von Boulenc, Xavier, Djebli, Nassim, Shi, Juan, Perrin, Laurent, Brian, William, Van Horn, Robert, Hurbin, Fabrice

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Use of PBPK modeling for drug–drug interactions prediction of rifapentine on other drugs by induction of CYP3A4/5 and CYP2B6 von Nicolas, Olivier, Vermet, Helene, Demers, Brigitte, Boulenc, Xavier, Sultan, Eric, Donat, François, Farenc, Christine

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Clopidogrel Pharmacodynamics and Pharmacokinetics in the Fed and Fasted State: A Randomized Crossover Study of Healthy Men von Hurbin, Fabrice, Boulenc, Xavier, Daskalakis, Nikki, Farenc, Christine, Taylor, Theresa, Bonneau, Damien, LaCreta, Frank, Cheng, Sue, Sultan, Eric

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Physiologically Based Pharmacokinetic Modeling for Sequential Metabolism: Effect of CYP2C19 Genetic Polymorphism on Clopidogrel and Clopidogrel Active Metabolite Pharmacokinetics von Djebli, Nassim, Fabre, David, Boulenc, Xavier, Fabre, Gérard, Sultan, Eric, Hurbin, Fabrice

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Optimization of the Antibacterial Spectrum and the Developability Profile of the Novel-Class Natural Product Corramycin von Renard, Stephane, Versluys, Stéphanie, Taillier, Thomas, Dubarry, Nelly, Leroi-Geissler, Corinne, Rey, Astrid, Cornaire, Emilie, Sordello, Sylvie, Carry, Jean-Christophe B., Angouillant-Boniface, Odile, Gouyon, Thierry, Thompson, Fabienne, Lebourg, Gilles, Certal, Victor, Balazs, Laszlo, Arranz, Esther, Doerflinger, Gilles, Bretin, Francois, Gervat, Vincent, Brohan, Eric, Kraft, Volker, Boulenc, Xavier, Ducelier, Cécile, Bacqué, Eric, Couturier, Cédric

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Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells von Vermet, Hélène, Raoust, Nathalie, Ngo, Robert, Esserméant, Luc, Klieber, Sylvie, Fabre, Gérard, Boulenc, Xavier

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Investigations with a humanised CYP3A4/3A7 mouse model von Doyle, Eddie, Coutant, Anne-Laure, Kapelyukh, Yury, Boulenc, Xavier

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IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds von Margolskee, Alison, Darwich, Adam S., Pepin, Xavier, Pathak, Shriram M., Bolger, Michael B., Aarons, Leon, Rostami-Hodjegan, Amin, Angstenberger, Jonas, Graf, Franziska, Laplanche, Loic, Müller, Thomas, Carlert, Sara, Daga, Pankaj, Murphy, Dónal, Tannergren, Christer, Yasin, Mohammed, Greschat-Schade, Susanne, Mück, Wolfgang, Muenster, Uwe, van der Mey, Dorina, Frank, Kerstin Julia, Lloyd, Richard, Adriaenssen, Lieve, Bevernage, Jan, De Zwart, Loeckie, Swerts, Dominique, Tistaert, Christophe, Van Den Bergh, An, Van Peer, Achiel, Beato, Stefania, Nguyen-Trung, Anh-Thu, Bennett, Joanne, McAllister, Mark, Wong, Mei, Zane, Patricia, Ollier, Céline, Vicat, Pascale, Kolhmann, Markus, Marker, Alexander, Brun, Priscilla, Mazuir, Florent, Beilles, Stéphane, Venczel, Marta, Boulenc, Xavier, Loos, Petra, Lennernäs, Hans, Abrahamsson, Bertil

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CYP3A4-based drug–drug interaction: CYP3A4 substrates’ pharmacokinetic properties and ketoconazole dose regimen effect von Boulenc, Xavier, Nicolas, Olivier, Hermabessière, Stéphanie, Zobouyan, Isabelle, Martin, Valérie, Donazzolo, Yves, Ollier, Céline

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PBPK modeling of irbesartan: incorporation of hepatic uptake von Chapy, Helene, Klieber, Sylvie, Brun, Priscilla, Gerbal-Chaloin, Sabine, Boulenc, Xavier, Nicolas, Olivier

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Importance of the paracellular pathway for the transport of a new bisphosphonate using the human CACO-2 monolayers model von Boulenc, Xavier, Marti, Eric, Joyeux, Henri, Roques, Claude, Berger, Yves, Fabre, Gérard

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Correlation between oral drug absorption in humans, and apparent drug permeability in TC-7 cells, a human epithelial intestinal cell line : Comparison with the parental Caco-2 cell... von GRES, M.-C, JULIAN, B, BOURRIE, M, MEUNIER, V, ROQUES, C, BERGER, M, BOULENC, X, BERGER, Y, FABRE, G

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Bisphosphonates increase tight junction permeability in the human intestinal epithelial (Caco-2) model von Boulenc, Xavier, Roques, Claude, Joyeux, Henri, Berger, Yves, Fabre, Gérard

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IMI – oral biopharmaceutics tools project – evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds von Margolskee, Alison, Darwich, Adam, Pepin, Xavier, Pathak, Shriram M, Bolger et al, Michael B, Aarons, Leon, Rostami-Hochaghan, Amin, Angstenberger, Jonas, Graf, Franziska, Laplanche, Loic, Muller, Thomas, Carlert, Sara, Daga, Pankaj, Murphy, Donal, Tannergren, Christer, Yasin, Mohammed, Greschat-Schade, Susanne, Muck, Wolfgang, Muenster, Uwe, van der Mey, Dorina, Frank, Kerstin, Lloyd, Richard, Adriaenssen, Lieve, Bevernage, Jan, De Zwart, Loeckie, Swerts, Dominique, Tistaert, Christophe, Van Den Bergh, An, Van Peer, Achiel, Beato, Stefania, Nguyen-Trung, Anh-Thu, Bennett, Joanne, McAllister, Mark, Wong, Mei, Zane, Patricia, Ollier, Celine, Vicat, Pascale, Kolhmann, Markus, Marker, Alexander, Brun, Priscilla, Mazuir, Florent, Beilles, Stephane, Venczel, Marta, Boulenc, Xavier, Loos, Petra, Lennernas, Hans, Abrahamsson, Bertil

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Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes von DALET‐BELUCHE, Isabelle, BOULENC, Xavier, FABRE, Gérard, MAUREL, Patrick, BONFILS, Claude

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Characterisation of a newly isolated Caco-2 clone (TC-7), as a model of transport processes and biotransformation of drugs von Caro, Isabelle, Boulenc, Xavier, Rousset, Monique, Meunier, Viviane, Bourrié, Martine, Julian, Bernand, Joyeux, Henri, Roques, Claude, Berger, Yves, Zweibaum, Alain, Fabre, Gérard

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Sodium lauryl sulphate increases tiludronate paracellular transport using human epithelial caco-2 monolayers von Boulenc, Xavier, Breul, Thierry, Gautier, Jean-Claude, Saudemon, Philippe, Joyeux, Henri, Roques, Claude, Berger, Yves, Fabre, Gérard

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Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes : cross reactivity with human forms von DALET-BELUCHE, I, BOULENC, X, FABRE, G, MAUREL, P, BONFILS, C

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