Acute systemic toxicity—prospects for tiered testing strategies von Botham, P.A

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Considerations for the development of guidance on dose level selection for developmental and reproductive toxicity studies von Lewis, R.W., Andrus, A.K., Arroyo, J., Brescia, S., Botham, P.A., Corvaro, M., Daston, G.P., Hofmann, T., Rodriguez, C., Sewell, F., van Ravenzwaay, B., Wiench, K., Marty, S.

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A prevalidation study on in vitro tests for acute skin irritation: results and evaluation by the Management Team von Fentem, J.H, Briggs, D, Chesné, C, Elliott, G.R, Harbell, J.W, Heylings, J.R, Portes, P, Roguet, R, van de Sandt, J.J.M, Botham, P.A

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The EC/HO international validation study on alternatives to the draize eye irritation test von Balls, M., Botham, P.A., Bruner, L.H., Spielmann, H.

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The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 2. Results and Evaluation by the Management Team von Fentem, J.H., Archer, G.E.B., Balls, M., Botham, P.A., Curren, R.D., Earl, L.K., Esdaile, D.J., Holzhütter, H.-G., Liebsch, M.

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Induction of respiratory hypersensitivity to diphenylmethane-4,4′-diisocyanate (MDI) in guinea pigs. Influence of route of exposure von Rattray, N.J., Botham, P.A., Hext, P.M., Woodcock, D.R., Fielding, I., Dearman, R.J., Kimber, I.

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On the skin sensitisation potential of rosin and oxidised rosin von Botham, P.A., Lees, D., Illing, H.P.A., Malmfors, Torbjorn

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Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node assays von Basketter, D.A., Selbie, E., Scholes, E.W., Lees, D., Kimber, I., Botham, P.A.

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Skin sensitization—A critical review of predictive test methods in animals and man von Botham, P.A., Basketter, D.A., Maurer, T., Mueller, D., Potokar, M., Bontinck, W.J.

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Allergy to laboratory animals: a follow up study of its incidence and of the influence of atopy and pre-existing sensitisation on its development von Botham, P A, Lamb, C T, Teasdale, E L, Bonner, S M, Tomenson, J A

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The murine local lymph node assay: results of an inter-laboratory trial von Kimber, I., Hilton, J., Botham, P.A., Basketter, D.A., Scholes, E.W., Miller, K., Robbins, M.C., Harrison, P.T.C., Gray, T.J.B., Waite, S.J.

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Identification of contact allergens using the murine local lymph node assay: Comparisons with the buehler occluded patch test in guinea pigs von Kimber, I., Hilton, J., Botham, P. A.

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The induction of respiratory allergy in guinea-pigs following intradermal injection of trimellitic anhydride: a comparison with the response to 2,4-dinitrochlorobenzene von Botham, P.A., Rattray, N.J., Woodcock, D.R., Walsh, S.T., Hext, P.M.

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A two-centre study for the evaluation and validation of an animal model for the assessment of the potential of small molecular weight chemicals to cause respiratory allergy von Blaikie, L., Morrow, T., Wilson, A.P., Hext, P., Hartop, P.J., Rattray, N.J., Woodcock, D., Botham, P.A.

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The discrimination between nickel-sensitive and non-nickel-sensitive subjects by an in vitro lymphocyte transformation test von EVERNESS, K.M., GAWKRODGER, D.J., BOTHAM, P.A., HUNTER, J.A.A.

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Eye irritation: Reference chemicals data bank von Bagley, D.M., Botham, P.A., Gardner, J.R., Holland, G., Kreiling, R., Lewis, R.W., Stringer, D.A., Walker, A.P.

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Allergy to laboratory animals: a prospective study of its incidence and of the influence of atopy on its development von Botham, P A, Davies, G E, Teasdale, E L

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Rodent thyroid toxicity and potential child neurodevelopmental impairment von Hannas, B.R., Asiimwe, A., A. Botham, P., Charlton, A., Guignard, D., Hallmark, N., Jacobi, S., Marty, S., Melching-Kollmuss, S., Sauer, U.G., Schneider, S., Strauss, V., van Ravenzwaay, B.

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Classification of chemicals as sensitisers based on new test methods von Botham, P.A.

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Validation—Lessons learned from practical experience von Fentem, J.H., Prinsen, M.K., Spielmann, H., Walum, E., Botham, P.A.

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