Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers von Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D., Rose, Christopher M., Cheung, Tommy K., Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S., Berlin, Michael, Yauch, Robert L.

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Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models von CHANG, Yong S, ADNANE, Jalila, WILKIE, Dean, CARTER, Christopher A, TAYLOR, Ian C. A, LYNCH, Mark, WILHELM, Scott, TRAIL, Pamela A, LEVY, Joan, HENDERSON, Arris, DAHAI XUE, BORTOLON, Elizabeth, ICHETOVKIN, Marina, CHEN, Charles, MCNABOLA, Angela

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Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs von Kou, Ponien, Levy, Elizabeth S, Nguyen, An D, Zhang, Donglu, Chen, Shu, Cui, Yusi, Zhang, Xing, Broccatelli, Fabio, Pizzano, Jennifer, Cantley, Jennifer, Bortolon, Elizabeth, Rousseau, Emma, Berlin, Michael, Dragovich, Peter, Sethuraman, Vijay

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Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs von Zhang, Donglu, Ma, Bin, Dragovich, Peter S., Ma, Li, Chen, Shu, Chen, Eugene C., Ye, Xiaofen, Liu, Joyce, Pizzano, Jennifer, Bortolon, Elizabeth, Chan, Emily, Zhang, Xing, Chen, Yi-Chen, Levy, Elizabeth S., Yauch, Robert L., Khojasteh, S. Cyrus, Hop, Cornelis E. C. A.

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Abstract 3075: Enhanced efficacy of ARV-471, a novel PROTAC® estrogen receptor degrader, in combination with targeted agents in estrogen receptor-positive (ER+) breast cancer model... von Teh, Jessica, Bortolon, Elizabeth, Pizzano, Jennifer, Pannone, Melissa, Landrette, Sean, Gedrich, Richard, Taylor, Ian

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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models von Berlin, Michael, Cantley, Jennifer, Bookbinder, Mark, Bortolon, Elizabeth, Broccatelli, Fabio, Cadelina, Greg, Chan, Emily W., Chen, Huifen, Chen, Xin, Cheng, Yunxing, Cheung, Tommy K., Davenport, Kim, DiNicola, Dean, Gordon, Debbie, Hamman, Brian D., Harbin, Alicia, Haskell, Roy, He, Mingtao, Hole, Alison J., Januario, Thomas, Kerry, Philip S., Koenig, Stefan G., Li, Limei, Merchant, Mark, Pérez-Dorado, Inmaculada, Pizzano, Jennifer, Quinn, Connor, Rose, Christopher M., Rousseau, Emma, Soto, Leofal, Staben, Leanna R., Sun, Hongming, Tian, Qingping, Wang, Jing, Wang, Weifeng, Ye, Crystal S., Ye, Xiaofen, Zhang, Penghong, Zhou, Yuhui, Yauch, Robert, Dragovich, Peter S.

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Abstract 432: Mechanisms of acquired resistance to ARV-471, a novel PROTAC® estrogen receptor degrader von Teh, Jessica, Bessonett, Shannon, Wu, Wendy, Kuhlberg, Christopher, Wynne, Alissa, Landrette, Sean, Andreoli, Monica, Bortolon, Elizabeth, Pizzano, Jennifer, Gedrich, Richard, Taylor, Ian

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Abstract PR09: KRAS-targeted PROTAC degraders are broadly efficacious against KRAS-dependent tumor models von Smith, Kathryn, Lopez-Arroyo, Andrea, Berk, Jason, Hegan, Peter, Nower, Peter, Tice, Samantha, Moutran, Aurelie, Pizzano, Jennifer, Dowtin, Amanda, Bookbinder, Mark, Bortolon, Elizabeth, Cadelina, Greg, Karim, Fazlul, Digianantonio, Katie, Bekes, Miklos, Medina, Jesus

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Synthesis and pharmacological characterization of a potent, orally active p38 kinase inhibitor von Dumas, Jacques, Hatoum-Mokdad, Holia, Sibley, Robert N, Smith, Roger A, Scott, William J, Khire, Uday, Lee, Wendy, Wood, Jill, Wolanin, Donald, Cooley, Jeffrey, Bankston, Donald, Redman, Aniko M, Schoenleber, Robert, Caringal, Yolanda, Gunn, David, Romero, Romulo, Osterhout, Martin, Paulsen, Holger, Housley, Timothy J, Wilhelm, Scott M, Pirro, John, Chien, Du-Shieng, Ranges, Gerald E, Shrikhande, Alka, Muzsi, Andrew, Bortolon, Elizabeth, Wakefield, Jean, Gianpaolo Ostravage, Cynthia, Bhargava, Ajay, Chau, Thuy

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