Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity:  Design, Synthesis, and X-ray Cocrystal Structure von Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek

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Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase von Tikhe, Jayashree G, Webber, Stephen E, Hostomsky, Zdenek, Maegley, Karen A, Ekkers, Anne, Li, Jianke, Yu, Xiao-Hong, Almassy, Robert J, Kumpf, Robert A, Boritzki, Theodore J, Zhang, Cathy, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R

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Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: The critical role of polyglutamylation von FAESSEL, H. M, SLOCUM, H. K, JACKSON, R. C, BORITZKI, T. J, RUSTUM, Y. M, NAIR, M. G, GRECO, W. R

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DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard von Gourdie, Trudi A, Valu, Kisione K, Gravatt, G. Lance, Boritzki, Theodore J, Baguley, Bruce C, Wakelin, Laurence P. G, Wilson, William R, Woodgate, Paul D, Denny, William A

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Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies von CALABRESE, Christopher R, BATEY, Michael A, MAEGLEY, Karen, CALVERT, Alan H, HOSTOMSKY, Zdenek, NEWELL, David R, CURTIN, Nicola J, THOMAS, Huw D, DURKACZ, Barbara W, WANG, Lan-Zhen, KYLE, Suzanne, SKALITZKY, Donald, LI, Janke, ZHANG, Catherine, BORITZKI, Theodore

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Inhibition of type II topoisomerase by fostriecin von Boritzki, Theodore J., Wolfard, Tammy S., Besserer, Judith A., Jackson, Robert C., Fry, David W.

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Identification of the major lesion from the reaction of an acridine targeted aniline mustard with DNA as an adenine N1 adduct von Boritzki, Theodore J, Palmer, Brian D, Coddington, Jan M, Denny, William A

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DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain von Valu, Kisione K, Gourdie, Trudi A, Boritzki, Theodore J, Gravatt, G. Lance, Baguley, Bruce C, Wilson, William R, Wakelin, Laurence P. G, Woodgate, Paul D, Denny, William A

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Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats von Jackson, R C, Lui, M S, Boritzki, T J, Morris, H P, Weber, G

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AG337, a novel lipophilic thymidylate synthase inhibitor : in vitro and in vivo preclinical studies von WEBBER, S, BARTLETT, C. A, BORITZKI, T. J, HILLIARD, J. A, HOWLAND, E. F, JOHNSTON, A. L, KOSA, M, MARGOSIAK, S. A, MORSE, C. A, SHETTY, B. V

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AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase von Boritzki, T J, Barlett, C A, Zhang, C, Howland, E F

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An inhibitor of glycinamide ribonucleotide formyltransferase is selectively cytotoxic to cells that lack a functional G1 checkpoint von Zhang, Cathy C., Boritzki, Theodore J., Jackson, Robert C.

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Design, Synthesis, and Evaluation of 3,4-Dihydro-2 H -[1,4]diazepino[6,7,1- hi ]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase von Tikhe, Jayashree G., Webber, Stephen E., Hostomsky, Zdenek, Maegley, Karen A., Ekkers, Anne, Li, Jianke, Yu, Xiao-Hong, Almassy, Robert J., Kumpf, Robert A., Boritzki, Theodore J., Zhang, Cathy, Calabrese, Chris R., Curtin, Nicola J., Kyle, Suzanne, Thomas, Huw D., Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T., Griffin, Roger J., Newell, David R.

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Identification of Potent Nontoxic Poly(ADP-Ribose) Polymerase-1 Inhibitors von Christopher R. Calabrese, Michael A. Batey, Huw D. Thomas, Barbara W. Durkacz, Lan-Zhen Wang, Suzanne Kyle, Donald Skalitzky, Janke Li, Catherine Zhang, Theodore Boritzki, Karen Maegley, Alan H. Calvert, Zdenek Hostomsky, David R. Newell, Nicola J. Curtin

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Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines:  Potent Inhibitors of Glycinamide Ribonucleotide Transformylase wit... von Varney, Michael D, Palmer, Cindy L, Romines, William H, Boritzki, Theodore, Margosiak, Stephen A, Almassy, Robert, Janson, Cheryl A, Bartlett, Charlotte, Howland, Eleanor J, Ferre, Rosanne

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In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9- cd]pyrazol-6(2 H)-ones (anthrapyrazo... von Fry, David W., Boritzki, Theodore J., Besserer, Judith A., Jackson, Robert C.

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Transport of the antitumor antibiotic CI-920 into L1210 leukemia cells by the reduced folate carrier system von FRY, D. W, BESSERER, J. A, BORITZKI, T. J

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Biochemical and antitumor activity of tiazofurin and its selenium analog (2-β- D-ribofuranosyl-4-selenazolecarboxamide) von Boritzki, Theodore J., Berry, David A., Besserer, Judith A., Dan Cook, P., Fry, David W., Leopold, Wilbur R., Jackson, Robert C.

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Biochemical pharmacology of the lipophilic antifolate, trimetrexate von Jackson, Robert C., Fry, David W., Boritzki, Theodore J., Besserer, Judith A., Leopold, Wilbur R., Sloan, Bernard J., Elslager, Edward F.

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Studies on the biochemical mechanism of the novel antitumor agent, CI-920 von FRY, D. W, BORITZKI, T. J, JACKSON, R. C

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