A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction von Kaptein, Suzanne J. F., Goethals, Olivia, Kiemel, Dominik, Marchand, Arnaud, Kesteleyn, Bart, Bonfanti, Jean-François, Bardiot, Dorothée, Stoops, Bart, Jonckers, Tim H. M., Dallmeier, Kai, Geluykens, Peggy, Thys, Kim, Crabbe, Marjolein, Chatel-Chaix, Laurent, Münster, Max, Querat, Gilles, Touret, Franck, de Lamballerie, Xavier, Raboisson, Pierre, Simmen, Kenny, Chaltin, Patrick, Bartenschlager, Ralf, Van Loock, Marnix, Neyts, Johan

Volltext

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor von Kesteleyn, Bart, Bonfanti, Jean-François, Bardiot, Dorothée, De Boeck, Benoît, Goethals, Olivia, Kaptein, Suzanne J. F., Stoops, Bart, Coesemans, Erwin, Fortin, Jérôme, Muller, Philippe, Doublet, Frédéric, Carlens, Gunter, Koukni, Mohamed, Smets, Wim, Raboisson, Pierre, Chaltin, Patrick, Simmen, Kenny, Loock, Marnix Van, Neyts, Johan, Marchand, Arnaud, Jonckers, Tim H. M.

Volltext

A novel pyrimidine forming cyclization von Leenders, Ruben, van de Sande, Marc, Bonfanti, Jean-François

Volltext

1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors von NYANGUILE, Origene, PAUWELS, Frederik, DEHERTOGH, Pascale, CUMMINGS, Maxwell D, BONFANTI, Jean-Francois, SIMMEN, Kenneth A, RABOISSON, Pierre, VAN DEN BROECK, Walter, BOUTTON, Carlo W, QUIRYNEN, Ludo, IVENS, Tania, VAN DER HELM, Liesbet, VANDERCRUYSSEN, Geneviève, MOSTMANS, Wendy, DELOUVROY, Frédéric

Volltext

Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors von Kesteleyn, Bart, Bardiot, Dorothée, Bonfanti, Jean-François, De Boeck, Benoît, Goethals, Olivia, Kaptein, Suzanne J. F., Stoops, Bart, Coesemans, Erwin, Fortin, Jérôme, Muller, Philippe, Doublet, Frédéric, Carlens, Gunter, Koukni, Mohamed, Smets, Wim, Raboisson, Pierre, Chaltin, Patrick, Simmen, Kenny, Van Loock, Marnix, Neyts, Johan, Marchand, Arnaud, Jonckers, Tim H. M.

Volltext

Palladium Catalyzed One-Pot Sequential Suzuki Cross-Coupling–Direct C–H Functionalization of Imidazo[1,2‑a]pyrazines von Gembus, Vincent, Bonfanti, Jean-François, Querolle, Olivier, Jubault, Philippe, Levacher, Vincent, Hoarau, Christophe

Volltext

Practical Synthesis of Ethyl 3‑Fluoro-1-pyrrole-2-carboxylate: A Key Fragment of a Potent Drug Candidate against Hepatitis B Virus von René, Adeline, Quilan, Maxime, Deng, Yicheng, Cheng, Yang, Teleha, Christopher A, Raboisson, Pierre, Bonfanti, Jean-François, Fortin, Jérôme, Charette, André. B, Pannecoucke, Xavier, Poisson, Thomas, Jubault, Philippe

Volltext

Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation von Kiemel, Dominik, Kroell, Ann-Sophie Helene, Denolly, Solène, Haselmann, Uta, Bonfanti, Jean-François, Andres, Jose Ignacio, Ghosh, Brahma, Geluykens, Peggy, Kaptein, Suzanne J. F., Wilken, Lucas, Scaturro, Pietro, Neyts, Johan, Van Loock, Marnix, Goethals, Olivia, Bartenschlager, Ralf

Volltext

Toward the Synthesis of Fluorinated Analogues of HCV NS3/4A Serine Protease Inhibitors Using Methyl α‑Amino-β-fluoro-β-vinylcyclopropanecarboxylate as Key Intermediate von Milanole, Gaëlle, Andriessen, Floris, Lemonnier, Gérald, Sebban, Muriel, Coadou, Gaël, Couve-Bonnaire, Samuel, Bonfanti, Jean-François, Jubault, Philippe, Pannecoucke, Xavier

Volltext

Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model von Ispas, Gabriela, Koul, Anil, Verbeeck, Johan, Sheehan, Jennifer, Sanders-Beer, Brigitte, Roymans, Dirk, Andries, Koen, Rouan, Marie-Claude, De Jonghe, Sandra, Bonfanti, Jean-François, Vanstockem, Marc, Simmen, Kenneth, Verloes, Rene

Volltext

Synthesis of Fluorinated Cyclopropyl Amino Acid Analogues: Toward the Synthesis of Original Fluorinated Peptidomimetics von Milanole, Gaëlle, Couve-Bonnaire, Samuel, Bonfanti, Jean-François, Jubault, Philippe, Pannecoucke, Xavier

Volltext

From Oxetane to Thietane: Extending the Antiviral Spectrum of 2′-Spirocyclic Uridines by Substituting Oxygen with Sulfur von Grosse, Sandrine, Tahri, Abdellah, Raboisson, Pierre, Houpis, Yannis, Stoops, Bart, Jacoby, Edgar, Neefs, Jean-Marc, Van Loock, Marnix, Goethals, Olivia, Geluykens, Peggy, Bonfanti, Jean-François, Jonckers, Tim H. M.

Volltext

Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein von Roymans, Dirk, De Bondt, Hendrik L, Arnoult, Eric, Geluykens, Peggy, Gevers, Tom, Van Ginderen, Marcia, Verheyen, Nick, Kim, Hidong, Willebrords, Rudy, Bonfanti, Jean-François, Bruinzeel, Wouter, Cummings, Maxwell D, van Vlijmen, Herman, Andries, Koen

Volltext

Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate. 2. Discovery of a Morpholinopropylaminobenzimidazole Derivative (TMC353121) von Bonfanti, Jean-François, Meyer, Christophe, Doublet, Frédéric, Fortin, Jérôme, Muller, Philippe, Queguiner, Laurence, Gevers, Tom, Janssens, Peggy, Szel, Heidi, Willebrords, Rudy, Timmerman, Philip, Wuyts, Koen, van Remoortere, Pieter, Janssens, Frans, Wigerinck, Piet, Andries, Koen

Volltext

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase von McGowan, David, Nyanguile, Origène, Cummings, Maxwell D., Vendeville, Sandrine, Vandyck, Koen, Van den Broeck, Walter, Boutton, Carlo W., De Bondt, Hendrik, Quirynen, Ludo, Amssoms, Katie, Bonfanti, Jean-François, Last, Stefaan, Rombauts, Klara, Tahri, Abdellah, Hu, Lili, Delouvroy, Frédéric, Vermeiren, Katrien, Vandercruyssen, Geneviève, Van der Helm, Liesbet, Cleiren, Erna, Mostmans, Wendy, Lory, Pedro, Pille, Geert, Van Emelen, Kristof, Fanning, Gregory, Pauwels, Frederik, Lin, Tse-I, Simmen, Kenneth, Raboisson, Pierre

Volltext

Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate, Part 1:  Improving the Pharmacokinetic Profile Using the Structure−Property Relationship von Bonfanti, Jean-François, Doublet, Frédéric, Fortin, Jérôme, Lacrampe, Jean, Guillemont, Jérôme, Muller, Philippe, Queguiner, Laurence, Arnoult, Eric, Gevers, Tom, Janssens, Peggy, Szel, Heidi, Willebrords, Rudy, Timmerman, Philip, Wuyts, Koen, Janssens, Frans, Sommen, Cois, Wigerinck, Piet, Andries, Koen

Volltext

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates von Goethals, Olivia, Kaptein, Suzanne J. F., Kesteleyn, Bart, Bonfanti, Jean-François, Van Wesenbeeck, Liesbeth, Bardiot, Dorothée, Verschoor, Ernst J., Verstrepen, Babs E., Fagrouch, Zahra, Putnak, J. Robert, Kiemel, Dominik, Ackaert, Oliver, Straetemans, Roel, Lachau-Durand, Sophie, Geluykens, Peggy, Crabbe, Marjolein, Thys, Kim, Stoops, Bart, Lenz, Oliver, Tambuyzer, Lotke, De Meyer, Sandra, Dallmeier, Kai, McCracken, Michael K., Gromowski, Gregory D., Rutvisuttinunt, Wiriya, Jarman, Richard G., Karasavvas, Nicos, Touret, Franck, Querat, Gilles, de Lamballerie, Xavier, Chatel-Chaix, Laurent, Milligan, Gregg N., Beasley, David W. C., Bourne, Nigel, Barrett, Alan D. T., Marchand, Arnaud, Jonckers, Tim H. M., Raboisson, Pierre, Simmen, Kenny, Chaltin, Patrick, Bartenschlager, Ralf, Bogers, Willy M., Neyts, Johan, Van Loock, Marnix

Volltext

Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation von Kiemel, Dominik, Kroell, Ann-Sophie Helene, Denolly, Solene, Haselmann, Uta, Bonfanti, Jean-Francois, Andres, Jose Ignacio, Ghosh, Brahma, Geluykens, Peggy, Kaptein, Suzanne J.F, Wilken, Lucas, Scaturro, Pietro, Neyts, Johan, Van Loock, Marnix, Goethals, Olivia, Bartenschlager, Ralf

Volltext

Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor von Kesteleyn, Bart, Bonfanti, Jean-Francois, Bardiot, Dorothee, De Boeck, Benoit, Goethals, Olivia, Kaptein, Suzanne J.F, Stoops, Bart, Coesemans, Erwin, Fortin, Jerome, Muller, Philippe, Doublet, Frederic, Carlens, Gunter, Koukni, Mohamed, Smets, Wim, Raboisson, Pierre, Chaltin, Patrick, Simmen, Kenny, Van Loock, Marnix, Neyts, Johan, Marchand, Arnaud, Jonckers, Tim H.M

Volltext

Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors von Kesteleyn, Bart, Bardiot, Dorotheie, Bonfanti, Jean-Francois, De Boeck, Benoit, Goethals, Olivia, Kaptein, Suzanne J.F, Stoops, Bart, Coesemans, Erwin, Fortin, Jeirome, Muller, Philippe, Doublet, Freideiric, Carlens, Gunter, Koukni, Mohamed, Smets, Wim, Raboisson, Pierre, Chaltin, Patrick, Simmen, Kenny, Van Loock, Marnix, Neyts, Johan, Marchand, Arnaud, Jonckers, Tim H.M

Volltext