Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C von Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D, Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F, Cotesta, Simona, Brachmann, Saskia M

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors von Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim S., Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel A., Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaëlle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac’h, Marie-Anne, Mura, Christophe, Sorge, Mickaël, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Hans, Zecri, Frederic J., Sedrani, Richard C., Ostermann, Nils, Brachmann, Saskia M., Cotesta, Simona

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS G12C for the Treatment of Solid Tumors von Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim S, Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel A, Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaëlle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac'h, Marie-Anne, Mura, Christophe, Sorge, Mickaël, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Hans, Zecri, Frederic J, Sedrani, Richard C, Ostermann, Nils, Brachmann, Saskia M, Cotesta, Simona

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PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN von BRACHMANN, Saskia Maria, WILCKEN, Rainer, BOMIO-CONFAGLIA, Claudio, GERSPACHER, Marc, WARIN, Nicolas, ZECRI, Frédéric, LORTHIOIS, Edwige Liliane Jeanne, VAUPEL, Andrea, RIGOLLIER, Pascal, MACHAUER, Rainer, RACINE, Sophie, COTESTA, Simona, LIMA, Fabio, MAH, Robert, STUTZ, Stefan, LEBLANC, Catherine

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PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN von BRACHMANN, Saskia Maria, WILCKEN, Rainer, BOMIO-CONFAGLIA, Claudio, GERSPACHER, Marc, WARIN, Nicolas, ZECRI, Frédéric, LORTHIOIS, Edwige Liliane Jeanne, VAUPEL, Andrea, RIGOLLIER, Pascal, MACHAUER, Rainer, RACINE, Sophie, COTESTA, Simona, LIMA, Fabio, MAH, Robert, STUTZ, Stefan, LEBLANC, Catherine

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PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN von BRACHMANN, Saskia Maria, WILCKEN, Rainer, BOMIO-CONFAGLIA, Claudio, GERSPACHER, Marc, WARIN, Nicolas, ZECRI, Frédéric, LORTHIOIS, Edwige Liliane Jeanne, VAUPEL, Andrea, RIGOLLIER, Pascal, MACHAUER, Rainer, RACINE, Sophie, COTESTA, Simona, LIMA, Fabio, MAH, Robert, STUTZ, Stefan, LEBLANC, Catherine

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PYRAZOLYL DERIVATIVES AS INHIBITORS OF THE KRAS MUTANT PROTEIN von MAH, ROBERT, RIGOLLIER, PASCAL, BRACHMANN, SASKIA MARIA, WILCKEN, RAINER, ZECRI, FREDERIC, LEBLANC, CATHERINE, BOMIO-CONFAGLIA, CLAUDIO, VAUPEL, ANDREA, COTESTA, SIMONA, GERSPACHER, MARC, LIMA, FABIO, RACINE, SOPHIE, WARIN, NICOLAS, MACHAUER, RAINER, STUTZ, STEFAN, LORTHIOIS, EDWIGE LILIANE JEANNE

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KRAS 돌연변이 단백질의 억제제로서의 피라졸릴 유도체 von WILCKEN RAINER, ZECRI FREDERIC, LORTHIOIS EDWIGE LILIANE JEANNE, VAUPEL ANDREA, BRACHMANN SASKIA MARIA, COTESTA SIMONA, RIGOLLIER PASCAL, STUTZ STEFAN, LEBLANC CATHERINE, LIMA FABIO, MACHAUER RAINER, MAH ROBERT, WARIN NICOLAS, BOMIO CONFAGLIA CLAUDIO, RACINE SOPHIE, GERSPACHER MARC

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Pyrazolyl derivatives as inhibitors of the KRAS mutant protein von MAH, ROBERT, RIGOLLIER, PASCAL, BRACHMANN, SASKIA MARIA, WILCKEN, RAINER, ZECRI, FREDERIC, LEBLANC, CATHERINE, BOMIO-CONFAGLIA, CLAUDIO, VAUPEL, ANDREA, COTESTA, SIMONA, GERSPACHER, MARC, LIMA, FABIO, RACINE, SOPHIE, WARIN, NICOLAS, MACHAUER, RAINER, STUTZ, STEFAN, LORTHIOIS, EDWIGE LILIANE JEANNE

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