Tyrosine kinase inhibitors: From rational design to clinical trials von Traxler, Peter, Bold, Guido, Buchdunger, Elisabeth, Caravatti, Giorgio, Furet, Pascal, Manley, Paul, O'Reilly, Terence, Wood, Jeanette, Zimmermann, Juerg

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Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis von Manley, Paul William, Bold, Guido, Brüggen, Josef, Fendrich, Gabrielle, Furet, Pascal, Mestan, Jürgen, Schnell, Christian, Stolz, Barbara, Meyer, Thomas, Meyhack, Bernd, Stark, Wilhelm, Strauss, Andre, Wood, Jeanette

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New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis von Bold, Guido, Altmann, Karl-Heinz, Frei, Jörg, Lang, Marc, Manley, Paul W, Traxler, Peter, Wietfeld, Bernhard, Brüggen, Josef, Buchdunger, Elisabeth, Cozens, Robert, Ferrari, Stefano, Furet, Pascal, Hofmann, Francesco, Martiny-Baron, Georg, Mestan, Jürgen, Rösel, Johannes, Sills, Matthew, Stover, David, Acemoglu, Figan, Boss, Eugen, Emmenegger, René, Lässer, Laurent, Masso, Elvira, Roth, Rosemarie, Schlachter, Christian, Vetterli, Werner, Wyss, Dominique, Wood, Jeanette M

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Anthranilic Acid Amides:  A Novel Class of Antiangiogenic VEGF Receptor Kinase Inhibitors von Manley, Paul W, Furet, Pascal, Bold, Guido, Brüggen, Josef, Mestan, Jürgen, Meyer, Thomas, Schnell, Christian R, Wood, Jeanette, Haberey, Martin, Huth, Andreas, Krüger, Martin, Menrad, Andreas, Ottow, Eckhard, Seidelmann, Dieter, Siemeister, Gerhard, Thierauch, Karl-Heinz

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Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors:  4-(Phenylamino)pyrazolo[3,4-d]pyrimidines von Traxler, Peter, Bold, Guido, Frei, Joerg, Lang, Marc, Lydon, Nicholas, Mett, Helmut, Buchdunger, Elisabeth, Meyer, Thomas, Mueller, Marcel, Furet, Pascal

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Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching von Furet, Pascal, Bold, Guido, Hofmann, Francesco, Manley, Paul, Meyer, Thomas, Altmann, Karl-Heinz

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The Total Synthesis and Biological Assessment of trans-Epothilone A von Altmann, Karl-Heinz, Bold, Guido, Caravatti, Giorgio, Denni, Donatienne, Flörsheimer, Andreas, Schmidt, Alfred, Rihs, Grety, Wartmann, Markus

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Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing von Pissot Soldermann, Carole, Simic, Oliver, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Wartmann, Markus, Bigaud, Marc, Weiss, Andreas, McSheehy, Paul, Endres, Ralf, Santos, Paulo, Blank, Jutta, Schuffenhauer, Ansgar, Bold, Guido, Buschmann, Nicole, Zoller, Thomas, Altmann, Eva, Manley, Paul W, Dix, Ina, Buchdunger, Elisabeth, Scesa, Julien, Quancard, Jean, Schlapbach, Achim, Bornancin, Frédéric, Radimerski, Thomas, Régnier, Catherine H

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The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition von Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric

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A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis von Bold, Guido, Schnell, Christian, Furet, Pascal, McSheehy, Paul, Brüggen, Josef, Mestan, Jürgen, Manley, Paul W, Drückes, Peter, Burglin, Marion, Dürler, Ursula, Loretan, Jacqueline, Reuter, Robert, Wartmann, Markus, Theuer, Andreas, Bauer-Probst, Beatrice, Martiny-Baron, Georg, Allegrini, Peter, Goepfert, Arnaud, Wood, Jeanette, Littlewood-Evans, Amanda

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Inhibition of Chronic and Acute Skin Inflammation by Treatment with a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor von Halin, Cornelia, Fahrngruber, Hermann, Meingassner, Josef G, Bold, Guido, Littlewood-Evans, Amanda, Stuetz, Anton, Detmar, Michael

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Tetra-substituted imidazoles as a new class of inhibitors of the p53–MDM2 interaction von Vaupel, Andrea, Bold, Guido, De Pover, Alain, Stachyra-Valat, Thérèse, Hergovich Lisztwan, Joanna, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal

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PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tum... von WOOD, J. M, BOLD, G, PERSOHN, E, RÖSEL, J, SCHNELL, C, STOVER, D, THEUER, A, TOWBIN, H, WENGER, F, WOODS-COOK, K, MENRAD, A, SIEMEISTER, G, BUCHDUNGER, E, SCHIRNER, M, THIERAUCH, K.-H, SCHNEIDER, M. R, DREVS, J, MARTINY-BARON, G, TOTZKE, F, MARME, D, COZENS, R, FERRARI, S, FREI, J, HOFMANN, F, MESTAN, J, METT, H, O'REILLY, T

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A General Strategy for Targeting Drugs to Bone von Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean-Michel

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Corrigendum to “Tetra-substituted imidazoles as a new class of inhibitors of the p53–MDM2 interaction” [Bioorg. Med. Chem. Lett. 24 (9) (2014) 2110–2114] von Vaupel, Andrea, Bold, Guido, De Pover, Alain, Stachyra-Valat, Thérèse, Hergovich Lisztwan, Joanna, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal

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Epothilones and Their Analogs – Potential New Weapons in the Fight Against Cancer von Altmann, Karl-Heinz, Bold, Guido, Caravatti, Giorgio, End, Nicole, Flörsheimer, Andreas, Guagnano, Vito, O'Reilly, Terence, Wartmann, Markus

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Aromatic Interactions with Phenylalanine 691 and Cysteine 828:  A Concept for FMS-like Tyrosine Kinase-3 Inhibition. Application to the Discovery of a New Class of Potential Antile... von Furet, Pascal, Bold, Guido, Meyer, Thomas, Roesel, Johannes, Guagnano, Vito

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The T‐cell fingerprint of MALT 1 paracaspase revealed by selective inhibition von Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric

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Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding von Marzinzik, Andreas L., Amstutz, René, Bold, Guido, Bourgier, Emmanuelle, Cotesta, Simona, Glickman, J. Fraser, Götte, Marjo, Henry, Christelle, Lehmann, Sylvie, Hartwieg, J. Constanze D., Ofner, Silvio, Pellé, Xavier, Roddy, Thomas P., Rondeau, Jean-Michel, Stauffer, Frédéric, Stout, Steven J., Widmer, Armin, Zimmermann, Johann, Zoller, Thomas, Jahnke, Wolfgang

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The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®) von GAUMANN, ANDREAS K.A, DREXLER, HANNES C.A, LANG, SVEN A, STOELTZING, OLIVER, DIERMEIER-DAUCHER, SIMONE, BUCHDUNGER, ELISABETH, WOOD, JEANETTE, BOLD, GUIDO, BREIER, GEORG

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