Regulation of Inflammation- and Infection-Driven Hematopoiesis von Boettcher, Steffen, Manz, Markus G

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Demand-adapted regulation of early hematopoiesis in infection and inflammation von Takizawa, Hitoshi, Boettcher, Steffen, Manz, Markus G.

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IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice von Kovtonyuk, Larisa V., Caiado, Francisco, Garcia-Martin, Santiago, Manz, Eva-Maria, Helbling, Patrick, Takizawa, Hitoshi, Boettcher, Steffen, Al-Shahrour, Fatima, Nombela-Arrieta, Cesar, Slack, Emma, Manz, Markus G.

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A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies von Boettcher, Steffen, Miller, Peter G, Sharma, Rohan, McConkey, Marie, Leventhal, Matthew, Krivtsov, Andrei V, Giacomelli, Andrew O, Wong, Waihay, Kim, Jesi, Chao, Sherry, Kurppa, Kari J, Yang, Xiaoping, Milenkowic, Kirsten, Piccioni, Federica, Root, David E, Rücker, Frank G, Flamand, Yael, Neuberg, Donna, Lindsley, R Coleman, Jänne, Pasi A, Hahn, William C, Jacks, Tyler, Döhner, Hartmut, Armstrong, Scott A, Ebert, Benjamin L

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Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway von Kurppa, Kari J., Liu, Yao, To, Ciric, Zhang, Tinghu, Fan, Mengyang, Vajdi, Amir, Knelson, Erik H., Xie, Yingtian, Lim, Klothilda, Cejas, Paloma, Portell, Andrew, Lizotte, Patrick H., Ficarro, Scott B., Li, Shuai, Chen, Ting, Haikala, Heidi M., Wang, Haiyun, Bahcall, Magda, Gao, Yang, Shalhout, Sophia, Boettcher, Steffen, Shin, Bo Hee, Thai, Tran, Wilkens, Margaret K., Tillgren, Michelle L., Mushajiang, Mierzhati, Xu, Man, Choi, Jihyun, Bertram, Arrien A., Ebert, Benjamin L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Awad, Mark M., Gokhale, Prafulla C., Kirschmeier, Paul T., Marto, Jarrod A., Camargo, Fernando D., Haq, Rizwan, Paweletz, Cloud P., Wong, Kwok-Kin, Barbie, David A., Long, Henry W., Gray, Nathanael S., Jänne, Pasi A.

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TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype von Sallman, David A., McLemore, Amy F., Aldrich, Amy L., Komrokji, Rami S., McGraw, Kathy L., Dhawan, Abhishek, Geyer, Susan, Hou, Hsin-An, Eksioglu, Erika A., Sullivan, Amy, Warren, Sarah, MacBeth, Kyle J., Meggendorfer, Manja, Haferlach, Torsten, Boettcher, Steffen, Ebert, Benjamin L., Al Ali, Najla H., Lancet, Jeffrey E., Cleveland, John L., Padron, Eric, List, Alan F.

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Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c) von Fiskus, Warren, Boettcher, Steffen, Daver, Naval, Mill, Christopher P., Sasaki, Koji, Birdwell, Christine E., Davis, John A., Takahashi, Koichi, Kadia, Tapan M., DiNardo, Courtney D., Jin, Qi, Qi, Yuan, Su, Xiaoping, McGeehan, Gerard M., Khoury, Joseph D., Ebert, Benjamin L., Bhalla, Kapil N.

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Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome von Kennedy, Alyssa L., Myers, Kasiani C., Bowman, James, Gibson, Christopher J., Camarda, Nicholas D., Furutani, Elissa, Muscato, Gwen M., Klein, Robert H., Ballotti, Kaitlyn, Liu, Shanshan, Harris, Chad E., Galvin, Ashley, Malsch, Maggie, Dale, David, Gansner, John M., Nakano, Taizo A., Bertuch, Alison, Vlachos, Adrianna, Lipton, Jeffrey M., Castillo, Paul, Connelly, James, Churpek, Jane, Edwards, John R., Hijiya, Nobuko, Ho, Richard H., Hofmann, Inga, Huang, James N., Keel, Siobán, Lamble, Adam, Lau, Bonnie W., Norkin, Maxim, Stieglitz, Elliot, Stock, Wendy, Walkovich, Kelly, Boettcher, Steffen, Brendel, Christian, Fleming, Mark D., Davies, Stella M., Weller, Edie A., Bahl, Christopher, Carter, Scott L., Shimamura, Akiko, Lindsley, R. Coleman

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Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation von Helbling, Patrick M., Piñeiro-Yáñez, Elena, Gerosa, Rahel, Boettcher, Steffen, Al-Shahrour, Fátima, Manz, Markus G., Nombela-Arrieta, César

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Clonal hematopoiesis in donors and long-term survivors of related allogeneic hematopoietic stem cell transplantation von Boettcher, Steffen, Wilk, C. Matthias, Singer, Jochen, Beier, Fabian, Burcklen, Elodie, Beisel, Christian, Ventura Ferreira, Monica S., Gourri, Elise, Gassner, Christoph, Frey, Beat M., Schanz, Urs, Skoda, Radek C., Ebert, Benjamin L., Brummendorf, Tim H., Beerenwinkel, Niko, Manz, Markus G.

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Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway von Wolf, Monika Julia, Hoos, Alexandra, Bauer, Judith, Boettcher, Steffen, Knust, Markus, Weber, Achim, Simonavicius, Nicole, Schneider, Christoph, Lang, Matthias, Stürzl, Michael, Croner, Roland S., Konrad, Andreas, Manz, Markus G., Moch, Holger, Aguzzi, Adriano, van Loo, Geert, Pasparakis, Manolis, Prinz, Marco, Borsig, Lubor, Heikenwalder, Mathias

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Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells von Boettcher, Steffen, Ziegler, Patrick, Schmid, Michael A, Takizawa, Hitoshi, van Rooijen, Nico, Kopf, Manfred, Heikenwalder, Mathias, Manz, Markus G

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Wnt to the rescue! A new role in granulopoiesis von Boettcher, Steffen

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Degradation of GSPT1 causes TP53-independent cell death in leukemia while sparing normal hematopoietic stem cells von Sellar, Rob S, Sperling, Adam S, Słabicki, Mikołaj, Gasser, Jessica A, McConkey, Marie E, Donovan, Katherine A, Mageed, Nada, Adams, Dylan N, Zou, Charles, Miller, Peter G, Dutta, Ravi K, Boettcher, Steffen, Lin, Amy E, Sandoval, Brittany, Quevedo Barrios, Vanessa A, Kovalcik, Veronica, Koeppel, Jonas, Henderson, Elizabeth K, Fink, Emma C, Yang, Lu, Chan, Anthony, Pokharel, Sheela Pangeni, Bergstrom, Erik J, Burt, Rajan, Udeshi, Namrata D, Carr, Steven A, Fischer, Eric S, Chen, Chun-Wei, Ebert, Benjamin L

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Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells von Mueller, Jan, Schimmer, Roman R, Koch, Christian, Schneiter, Florin, Fullin, Jonas, Lysenko, Veronika, Pellegrino, Christian, Klemm, Nancy, Russkamp, Norman, Myburgh, Renier, Volta, Laura, Theocharides, Alexandre PA, Kurppa, Kari J, Ebert, Benjamin L, Schroeder, Timm, Manz, Markus G, Boettcher, Steffen

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Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1 von Fiskus, Warren, Mill, Christopher P., Birdwell, Christine, Davis, John A., Das, Kaberi, Boettcher, Steffen, Kadia, Tapan M., DiNardo, Courtney D., Takahashi, Koichi, Loghavi, Sanam, Soth, Michael J., Heffernan, Tim, McGeehan, Gerard M., Ruan, Xinjia, Su, Xiaoping, Vakoc, Christopher R., Daver, Naval, Bhalla, Kapil N.

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LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance von Ziegler, Patrick, Boettcher, Steffen, Takizawa, Hitoshi, Manz, Markus G., Brümmendorf, Tim H.

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Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics von Carter, Bing Z., Mak, Po Yee, Tao, Wenjing, Ayoub, Edward, Ostermann, Lauren B., Huang, Xuelin, Loghavi, Sanam, Boettcher, Steffen, Nishida, Yuki, Ruvolo, Vivian, Hughes, Paul E., Morrow, Phuong K., Haferlach, Torsten, Kornblau, Steven, Muftuoglu, Muharrem, Andreeff, Michael

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DEPDC1/LET-99 participates in an evolutionarily conserved pathway for anti-tubulin drug-induced apoptosis von Sendoel, Ataman, Maida, Simona, Zheng, Xue, Teo, Youjin, Stergiou, Lilli, Rossi, Carlo-Alberto, Subasic, Deni, Pinto, Sergio M., Kinchen, Jason M., Shi, Moyin, Boettcher, Steffen, Meyer, Joel N., Manz, Markus G., Bano, Daniele, Hengartner, Michael O.

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Emergency granulopoiesis von Manz, Markus G., Boettcher, Steffen

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