Mechanisms of isoniazid-induced idiosyncratic liver injury: Emerging role of mitochondrial stress von Boelsterli, Urs A, Lee, Kang Kwang

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Acetaminophen overdose‐induced liver injury in mice is mediated by peroxynitrite independently of the cyclophilin D‐regulated permeability transition von LoGuidice, Amanda, Boelsterli, Urs A.

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Understanding and modulating mammalian-microbial communication for improved human health von Mani, Sridhar, Boelsterli, Urs A, Redinbo, Matthew R

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Bypassing the compromised mitochondrial electron transport with methylene blue alleviates efavirenz/isoniazid-induced oxidant stress and mitochondria-mediated cell death in mouse h... von Lee, Kang Kwang, Boelsterli, Urs A

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Isoniazid-induced cell death is precipitated by underlying mitochondrial complex I dysfunction in mouse hepatocytes von Lee, Kang Kwang, Fujimoto, Kazunori, Zhang, Carmen, Schwall, Christine T, Alder, Nathan N, Pinkert, Carl A, Krueger, Winfried, Rasmussen, Theodore, Boelsterli, Urs A

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Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I von Imaizumi, Naoki, Kwang Lee, Kang, Zhang, Carmen, Boelsterli, Urs A

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Protection from diclofenac-induced small intestinal injury by the JNK inhibitor SP600125 in a mouse model of NSAID-associated enteropathy von Ramirez-Alcantara, Veronica, LoGuidice, Amanda, Boelsterli, Urs A

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Integrative Toxicoproteomics Implicates Impaired Mitochondrial Glutathione Import as an Off-Target Effect of Troglitazone von Lee, Yie Hou, Goh, Wilson Wen Bin, Ng, Choon Keow, Raida, Manfred, Wong, Limsoon, Lin, Qingsong, Boelsterli, Urs A, Chung, Maxey C. M

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Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity von Kashimshetty, Rohini, Desai, Varsha G., Kale, Vijay M., Lee, Taewon, Moland, Carrie L., Branham, William S., New, Lee S., Chan, Eric C.Y., Younis, Husam, Boelsterli, Urs A.

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Pharmacologic Targeting or Genetic Deletion of Mitochondrial Cyclophilin D Protects from NSAID-Induced Small Intestinal Ulceration in Mice von LoGuidice, Amanda, Ramirez-Alcantara, Veronica, Proli, Anthony, Gavillet, Bruno, Boelsterli, Urs A.

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The Mitochondrial Superoxide/Thioredoxin-2/Ask1 Signaling Pathway is Critically Involved in Troglitazone-Induced Cell Injury to Human Hepatocytes von Lim, Priscilla L. K., Liu, Jianchao, Go, Mei L., Boelsterli, Urs A.

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Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice von LoGuidice, Amanda, Wallace, Bret D, Bendel, Lauren, Redinbo, Matthew R, Boelsterli, Urs A

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ANIMAL MODELS OF HUMAN DISEASE IN DRUG SAFETY ASSESSMENT von Boelsterli, Urs A.

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Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes von Latchoumycandane, Calivarathan, Seah, Quee Ming, Tan, Rachel C.H., Sattabongkot, Jetsumon, Beerheide, Walter, Boelsterli, Urs A.

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Proteomics profiling of hepatic mitochondria in heterozygous Sod2+/− mice, an animal model of discreet mitochondrial oxidative stress von Lee, Yie Hou, Boelsterli, Urs A., Lin, Qingsong, Chung, Maxey C. M.

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Troglitazone-Induced Hepatic Necrosis in an Animal Model of Silent Genetic Mitochondrial Abnormalities von Ong, Michie M.K., Latchoumycandane, Calivarathan, Boelsterli, Urs A.

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Healthy animals and animal models of human disease(s) in safety assessment of human pharmaceuticals, including therapeutic antibodies von Dixit, Rakesh, Boelsterli, Urs A.

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Selective Protein Adduct Formation of Diclofenac Glucuronide Is Critically Dependent on the Rat Canalicular Conjugate Export Pump (Mrp2) von Seitz, Sven, Kretz-Rommel, Anke, Oude Elferink, Ronald P. J, Boelsterli, Urs A

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Mechanisms of NSAID-induced hepatotoxicity: Focus on nimesulide von BOELSTERLI, Urs A

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Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction von Hsiao, Chin-Ju J., Younis, Husam, Boelsterli, Urs A.

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