Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction von Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmanna, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin

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Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer von Lücking, Ulrich, Kosemund, Dirk, Böhnke, Niels, Lienau, Philip, Siemeister, Gerhard, Denner, Karsten, Bohlmann, Rolf, Briem, Hans, Terebesi, Ildiko, Bömer, Ulf, Schäfer, Martina, Ince, Stuart, Mumberg, Dominik, Scholz, Arne, Izumi, Raquel, Hwang, Stuart, von Nussbaum, Franz

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Mono- and multimeric PSMA-targeting small molecule-thorium-227 conjugates for optimized efficacy and biodistribution in preclinical models von Böhnke, Niels, Indrevoll, Bård, Hammer, Stefanie, Papple, Alex, Kristian, Alexander, Briem, Hans, Celik, Arif, Mumberg, Dominik, Cuthbertson, Alan, Zitzmann-Kolbe, Sabine

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A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy von Böhnke, Niels, Berger, Markus, Griebenow, Nils, Rottmann, Antje, Erkelenz, Michael, Hammer, Stefanie, Berndt, Sandra, Günther, Judith, Wengner, Antje M., Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Jörißen, Hannah, Barak, Naomi, Bömer, Ulf, Hillig, Roman C., Eberspaecher, Uwe, Weiske, Jörg, Giese, Anja, Mumberg, Dominik, Nising, Carl Friedrich, Weinmann, Hilmar, Sommer, Anette

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Abstract 677: Effective depletion of M2 macrophages by CD206-NAMPT-ADCs von Berndt, Sandra, Filarsky, Katharina, Smith, Patrick, Boehnke, Niels, Berger, Markus, Eser, Fionnuala McAleese, Lerchen, Hans-Georg, Ellinger, Phillip, Gehrmann, Mathias, Wu, Jim, Hildebrand, Dominic, Kreft, Bertolt, Gritzan, Uwe

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Radiofluorinated Derivatives of 2‑(Phosphonomethyl)pentanedioic Acid as Inhibitors of Prostate Specific Membrane Antigen (PSMA) for the Imaging of Prostate Cancer von Graham, Keith, Lesche, Ralf, Gromov, Alexey V, Böhnke, Niels, Schäfer, Martina, Hassfeld, Jorma, Dinkelborg, Ludger, Kettschau, Georg

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Abstract 5440: Development of a novel PSMA-targeting small molecule-Thorium-227 conjugate for the treatment of prostate cancer von Boehnke, Niels, Indrevoll, Bård, Hammer, Stefanie, Papple, Alex, Kristian, Alexander, Cuthbertson, Alan, Zitzmann-Kolbe, Sabine

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Abstract 1807: Anti-tumor activity of a novel structural class of NAMPT inhibitor-based ADCs in models of hematologic and solid tumor indications von Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Boehnke, Niels, Berger, Markus, Griebenow, Nils, Steffen, Andreas, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Giese, Anja, Quanz, Maria, Bao, Zhengzheng, Wu, Xiuli, Weinmann, Hilmar, Linden, Lars, Kreft, Bertolt, Mumberg, Dominik

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Preclinical evaluation of BAY 1075553, a novel 18F-labelled inhibitor of prostate-specific membrane antigen for PET imaging of prostate cancer von Lesche, Ralf, Kettschau, Georg, Gromov, Alexey V., Böhnke, Niels, Borkowski, Sandra, Mönning, Ursula, Hegele-Hartung, Christa, Döhr, Olaf, Dinkelborg, Ludger M., Graham, Keith

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Three-Component Domino Knoevenagel/Hetero-Diels-Alder Reaction for the Synthesis of the Amino Sugars 2-Acetoxyforosamine and 2-Acetoxyossamine - Experimental and Theoretical Result... von Tietze, Lutz F., Dietz, Simone, Böhnke, Niels, Düfert, M. Alexander, Objartel, Ina, Stalke, Dietmar

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Discovery of Rigidified α,β-Unsaturated Imines as New Resistance-breaking Insecticides for Malaria Vector Control von Arlt, Alexander, Böhnke, Niels, Horstmann, Sebastian, Vermeer, Arnoldus W P, Werner, Stefan, Velten, Robert

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Synthesis of Novel Spinosyn A Analogues by Pd-Mediated Transformations von Tietze, Lutz F., Brasche, Gordon, Grube, Alexander, Böhnke, Niels, Stadler, Christian

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Synthesis of Enantiomerically Pure Cyclopentene Building Blocks von Tietze, Lutz F., Stadler, Christian, Böhnke, Niels, Brasche, Gordon, Grube, Alexander

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Multiple Palladium-Catalyzed Reactions for the Synthesis of Analogues of the Highly Potent Insecticide Spinosyn A von Tietze, Lutz F., Brasche, Gordon, Stadler, Christian, Grube, Alexander, Böhnke, Niels

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Preparation of (2R)-2-acetoxy-D-forosamine for the total synthesis of spinosyns von Tietze, Lutz F., Böhnke, Niels, Brasche, Gordon

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HETEROCYCLIC COMPOUNDS AS PESTICIDES von HORN, Karin, ILG, Kerstin, VERMEER, Arnoldus, GOERGENS, Ulrich, VELTEN, Robert, PORTZ, Daniela, ARLT, Alexander, TURBERG, Andreas, HORSTMANN, Sebastian, BOEHNKE, Niels

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Heterocyclic compounds as pesticides von Goergens, Ulrich, Portz, Daniela, Turberg, Andreas, Horn, Karin, Horstmann, Sebastian, Ilg, Kerstin, Boehnke, Niels, Velten, Robert, Arlt, Alexander, Vermeer, Arnoldus

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Heterocyclic amino acids for prostate cancer imaging von BOEHNKE, NIELS

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2-{[2-(PHENYLOXYMETHYL)PYRIDIN-5-YL]OXY}-ETHANAMIN-DERIVATIVES AND RELATED COMPOUNDS AS PESTICIDES E.G. FOR CROP PROTECTION von HORN, Karin, ILG, Kerstin, VERMEER, Arnoldus, GOERGENS, Ulrich, VELTEN, Robert, PORTZ, Daniela, ARLT, Alexander, TURBERG, Andreas, HORSTMANN, Sebastian, BOEHNKE, Niels

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NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES von HORN, Karin, ILG, Kerstin, VERMEER, Arnoldus, GOERGENS, Ulrich, VELTEN, Robert, PORTZ, Daniela, ARLT, Alexander, TURBERG, Andreas, HORSTMANN, Sebastian, BOEHNKE, Niels

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