Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor von Martin, Laetitia J, Koegl, Manfred, Bader, Gerd, Cockcroft, Xiao-Ling, Fedorov, Oleg, Fiegen, Dennis, Gerstberger, Thomas, Hofmann, Marco H, Hohmann, Anja F, Kessler, Dirk, Knapp, Stefan, Knesl, Petr, Kornigg, Stefan, Müller, Susanne, Nar, Herbert, Rogers, Catherine, Rumpel, Klaus, Schaaf, Otmar, Steurer, Steffen, Tallant, Cynthia, Vakoc, Christopher R, Zeeb, Markus, Zoephel, Andreas, Pearson, Mark, Boehmelt, Guido, McConnell, Darryl

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Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction von Gollner, Andreas, Rudolph, Dorothea, Arnhof, Heribert, Bauer, Markus, Blake, Sophia M, Boehmelt, Guido, Cockroft, Xiao-Ling, Dahmann, Georg, Ettmayer, Peter, Gerstberger, Thomas, Karolyi-Oezguer, Jale, Kessler, Dirk, Kofink, Christiane, Ramharter, Juergen, Rinnenthal, Jörg, Savchenko, Alexander, Schnitzer, Renate, Weinstabl, Harald, Weyer-Czernilofsky, Ulrike, Wunberg, Tobias, McConnell, Darryl B

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Expansion of DUB functionality generated by alternative isoforms - USP35, a case study von Leznicki, Pawel, Natarajan, Jayaprakash, Bader, Gerd, Spevak, Walter, Schlattl, Andreas, Abdul Rehman, Syed Arif, Pathak, Deepika, Weidlich, Simone, Zoephel, Andreas, Bordone, Marie C, Barbosa-Morais, Nuno L, Boehmelt, Guido, Kulathu, Yogesh

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Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria von Junk, Lukas, Schmiedel, Volker M., Guha, Somraj, Fischel, Katharina, Greb, Peter, Vill, Kristin, Krisilia, Violetta, van Geelen, Lasse, Rumpel, Klaus, Kaur, Parvinder, Krishnamurthy, Ramya V., Narayanan, Shridhar, Shandil, Radha Krishan, Singh, Mayas, Kofink, Christiane, Mantoulidis, Andreas, Biber, Philipp, Gmaschitz, Gerhard, Kazmaier, Uli, Meinhart, Anton, Leodolter, Julia, Hoi, David, Junker, Sabryna, Morreale, Francesca Ester, Clausen, Tim, Kalscheuer, Rainer, Weinstabl, Harald, Boehmelt, Guido

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Tumor cell‐specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase von Peter, Stefanie, Bultinck, Jennyfer, Myant, Kevin, Jaenicke, Laura A, Walz, Susanne, Müller, Judith, Gmachl, Michael, Treu, Matthias, Boehmelt, Guido, Ade, Carsten P, Schmitz, Werner, Wiegering, Armin, Otto, Christoph, Popov, Nikita, Sansom, Owen, Kraut, Norbert, Eilers, Martin

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Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1 von Blagoveshchenskaya, Anastasia, Cheong, Fei Ying, Rohde, Holger M, Glover, Greta, Knödler, Andreas, Nicolson, Teresa, Boehmelt, Guido, Mayinger, Peter

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The Human Phosphatidylinositol Phosphatase SAC1 Interacts with the Coatomer I Complex von Rohde, Holger M., Cheong, Fei Ying, Konrad, Gerlinde, Paiha, Karin, Mayinger, Peter, Boehmelt, Guido

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BacPROTACs mediate targeted protein degradation in bacteria von Morreale, Francesca E., Kleine, Stefan, Leodolter, Julia, Junker, Sabryna, Hoi, David M., Ovchinnikov, Stepan, Okun, Anastasia, Kley, Juliane, Kurzbauer, Robert, Junk, Lukas, Guha, Somraj, Podlesainski, David, Kazmaier, Uli, Boehmelt, Guido, Weinstabl, Harald, Rumpel, Klaus, Schmiedel, Volker M., Hartl, Markus, Haselbach, David, Meinhart, Anton, Kaiser, Markus, Clausen, Tim

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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design von Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio

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Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers von Schick, Sandra, Rendeiro, André F., Runggatscher, Kathrin, Ringler, Anna, Boidol, Bernd, Hinkel, Melanie, Májek, Peter, Vulliard, Loan, Penz, Thomas, Parapatics, Katja, Schmidl, Christian, Menche, Jörg, Boehmelt, Guido, Petronczki, Mark, Müller, André C., Bock, Christoph, Kubicek, Stefan

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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival von Hoi, David M., Junker, Sabryna, Junk, Lukas, Schwechel, Kristin, Fischel, Katharina, Podlesainski, David, Hawkins, Paige M.E., van Geelen, Lasse, Kaschani, Farnusch, Leodolter, Julia, Morreale, Francesca Ester, Kleine, Stefan, Guha, Somraj, Rumpel, Klaus, Schmiedel, Volker M., Weinstabl, Harald, Meinhart, Anton, Payne, Richard J., Kaiser, Markus, Hartl, Markus, Boehmelt, Guido, Kazmaier, Uli, Kalscheuer, Rainer, Clausen, Tim

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Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3 von Böttcher, Jark, Dilworth, David, Reiser, Ulrich, Neumüller, Ralph A., Schleicher, Michael, Petronczki, Mark, Zeeb, Markus, Mischerikow, Nikolai, Allali-Hassani, Abdellah, Szewczyk, Magdalena M., Li, Fengling, Kennedy, Steven, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Brown, Peter J., Huber, Kilian V. M., Rogers, Catherine M., Wells, Carrow I., Fedorov, Oleg, Rumpel, Klaus, Zoephel, Andreas, Mayer, Moriz, Wunberg, Tobias, Böse, Dietrich, Zahn, Stephan, Arnhof, Heribert, Berger, Helmut, Reiser, Christoph, Hörmann, Alexandra, Krammer, Teresa, Corcokovic, Maja, Sharps, Bernadette, Winkler, Sandra, Häring, Daniela, Cockcroft, Xiao-Ling, Fuchs, Julian E., Müllauer, Barbara, Weiss-Puxbaum, Alexander, Gerstberger, Thomas, Boehmelt, Guido, Vakoc, Christopher R., Arrowsmith, Cheryl H., Pearson, Mark, McConnell, Darryl B.

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Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage von Jackson, Mark, Ahmari, Niousha, Wu, Jianqiang, Rizvi, Tilat A., Fugate, Elizabeth, Kim, Mi-OK, Dombi, Eva, Arnhof, Heribert, Boehmelt, Guido, Düchs, Matthias J., Long, Clive J., Maier, Udo, Trapani, Francesca, Hofmann, Marco H., Ratner, Nancy

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Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15 von Teyra, Joan, Singer, Alex U., Schmitges, Frank W., Jaynes, Patrick, Kit Leng Lui, Sarah, Polyak, Maria J., Fodil, Nassima, Krieger, Jonathan R., Tong, Jiefei, Schwerdtfeger, Carsten, Brasher, Bradley B., Ceccarelli, Derek F.J., Moffat, Jason, Sicheri, Frank, Moran, Michael F., Gros, Philippe, Eichhorn, Pieter J.A., Lenter, Martin, Boehmelt, Guido, Sidhu, Sachdev S.

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Systematic characterization of BAF mutations provides insights into intra-complex synthetic lethalities in human cancers von Schick, Sandra, Rendeiro, André F., Runggatscher, Kathrin, Ringler, Anna, Boidol, Bernd, Hinkel, Melanie, Májek, Peter, Vulliard, Loan, Penz, Thomas, Parapatics, Katja, Schmidl, Christian, Menche, Jörg, Boehmelt, Guido, Petronczki, Mark, Mueller, André C., Bock, Christoph, Kubicek, Stefan

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Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases von Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K, Baumann, Christoph, Rudolph, Dorothea, Baumgartinger, Rosa, Strauss, Eva, Haslinger, Christian, Tontsch-Grunt, Ulrike, Waizenegger, Irene C, Solca, Flavio, Bader, Gerd, Zoephel, Andreas, Treu, Matthias, Reiser, Ulrich, Garin-Chesa, Pilar, Boehmelt, Guido, Kraut, Norbert, Quant, Jens, Adolf, Günther R

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Expansion of DUB functionality generated by alternative isoforms - USP35, a case study von Leznicki, Pawel, Natarajan, Jayaprakash, Bader, Gerd, Spevak, Walter, Schlattl, Andreas, Rehman, Syed Arif Abdul, Pathak, Deepika, Weidlich, Simone, Zoephel, Andreas, Bordone, Marie C, Barbosa-Morais, Nuno L, Boehmelt, Guido, Kulathu, Yogesh

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Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design von Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio

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Abstract 1919: Pharmacological characterization of BI 847325, a dual inhibitor of MEK and Aurora kinases von Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K., Boehmelt, Guido, Garin-Chesa, Pilar, Kraut, Nobert, Rudolph, Dorothea, Solca, Flavio, Tontsch-Grunt, Ulrike, Waizenegger, Irene C., Adolf, Günther R.

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Tumor cell‐specific inhibition of MYC function using small molecule inhibitors of the HUWE 1 ubiquitin ligase von Peter, Stefanie, Bultinck, Jennyfer, Myant, Kevin, Jaenicke, Laura A, Walz, Susanne, Müller, Judith, Gmachl, Michael, Treu, Matthias, Boehmelt, Guido, Ade, Carsten P, Schmitz, Werner, Wiegering, Armin, Otto, Christoph, Popov, Nikita, Sansom, Owen, Kraut, Norbert, Eilers, Martin

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