Therapeutic and diagnostic implications of Hsp90 activation von Kamal, Adeela, Boehm, Marcus F, Burrows, Francis J

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BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90 von Lundgren, Karen, Zhang, Hong, Brekken, John, Huser, Nanni, Powell, Rachel E, Timple, Noel, Busch, David J, Neely, Laura, Sensintaffar, John L, Yang, Yong-ching, McKenzie, Andres, Friedman, Jessica, Scannevin, Robert, Kamal, Adeela, Hong, Kevin, Kasibhatla, Srinivas R, Boehm, Marcus F, Burrows, Francis J

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EC144 Is a Potent Inhibitor of the Heat Shock Protein 90 von Shi, Jiandong, Van de Water, Ryan, Hong, Kevin, Lamer, Ryan B, Weichert, Kenneth W, Sandoval, Cristina M, Kasibhatla, Srinivas R, Boehm, Marcus F, Chao, Jianhua, Lundgren, Karen, Timple, Noelito, Lough, Rachel, Ibanez, Gerardo, Boykin, Christina, Burrows, Francis J, Kehry, Marilyn R, Yun, Theodore J, Harning, Erin K, Ambrose, Christine, Thompson, Jeffrey, Bixler, Sarah A, Dunah, Anthone, Snodgrass-Belt, Pamela, Arndt, Joseph, Enyedy, Istvan J, Li, Ping, Hong, Victor S, McKenzie, Andres, Biamonte, Marco A

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7‘-Substituted Benzothiazolothio- and Pyridinothiazolothio-Purines as Potent Heat Shock Protein 90 Inhibitors von Zhang, Lin, Fan, Junhua, Vu, Khang, Hong, Kevin, Le Brazidec, Jean-Yves, Shi, Jiandong, Biamonte, Marco, Busch, David J, Lough, Rachel E, Grecko, Roy, Ran, Yingqing, Sensintaffar, John L, Kamal, Adeela, Lundgren, Karen, Burrows, Francis J, Mansfield, Robert, Timony, Gregg A, Ulm, Edgar H, Kasibhatla, Srinivas R, Boehm, Marcus F

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Inhibition of mast cell degranulation by novel small molecule MRGPRX2 antagonists von Wollam, Joshua, Solomon, Michelle, Villescaz, Christiane, Lanier, Marion, Evans, Samantha, Bacon, Corinne, Freeman, David, Vasquez, Alexis, Vest, Alan, Napora, Jim, Charlot, Brittney, Cavarlez, Christine, Kim, Andrew, Dvorak, Lisa, Selfridge, Brandon, Huang, Liming, Nevarez, Andres, Dedman, Harry, Brooks, Jennifer, Frischbutter, Stefan, Metz, Martin, Serhan, Nadine, Gaudenzio, Nicolas, Timony, Gregg, Martinborough, Esther, Boehm, Marcus F., Viswanath, Veena

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Results From the First‐in‐Human Study With Ozanimod, a Novel, Selective Sphingosine‐1‐Phosphate Receptor Modulator von Tran, Jonathan Q., Hartung, Jeffrey P., Peach, Robert J., Boehm, Marcus F., Rosen, Hugh, Smith, Heather, Brooks, Jennifer L., Timony, Gregg A., Olson, Allan D., Gujrathi, Sheila, Frohna, Paul A.

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Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists von Mukherjee, Ranjan, Davies, Peter J. A, Crombie, Diane L, Bischoff, Eric D, Cesario, Rosemary M, Jow, Lily, Hamann, Lawrence G, Boehm, Marcus F, Mondon, Carl E, Nadzan, Alex M, Paterniti, James R, Heyman, Richard A

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors von Burrows, Francis J, Kamal, Adeela, Thao, Lia, Sensintaffar, John, Zhang, Lin, Boehm, Marcus F, Fritz, Lawrence C

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Synthesis and Structure-Activity Relationships of Novel Retinoid X Receptor-Selective Retinoids von Boehm, Marcus F, Zhang, Lin, Badea, Beth Ann, White, Steven K, Mais, Dale E, Berger, Elaine, Suto, Carla M, Goldman, Mark E, Heyman, Richard A

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Cardiac Safety of Ozanimod, a Novel Sphingosine‐1‐Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study von Tran, Jonathan Q., Hartung, Jeffrey P., Olson, Allan D., Mendzelevski, Boaz, Timony, Gregg A., Boehm, Marcus F., Peach, Robert J., Gujrathi, Sheila, Frohna, Paul A.

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Rationally Designed High-Affinity 2-Amino-6-halopurine Heat Shock Protein 90 Inhibitors That Exhibit Potent Antitumor Activity von Kasibhatla, Srinivas R, Hong, Kevin, Biamonte, Marco A, Busch, David J, Karjian, Patricia L, Sensintaffar, John L, Kamal, Adeela, Lough, Rachel E, Brekken, John, Lundgren, Karen, Grecko, Roy, Timony, Gregg A, Ran, Yingqing, Mansfield, Robert, Fritz, Lawrence C, Ulm, Edgar, Burrows, Francis J, Boehm, Marcus F

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Design, Synthesis, and Structure−Activity Relationship Studies of Novel 6,7-Locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic Acids von Michellys, Pierre-Yves, Ardecky, Robert J, Chen, Jyun-Hung, D'Arrigo, Jennifer, Grese, Timothy A, Karanewsky, Donald S, Leibowitz, Mark D, Liu, Sha, Mais, Dale A, Mapes, Christopher M, Montrose-Rafizadeh, Chahrzad, Ogilvie, Katheen M, Reifel-Miller, Anne, Rungta, Deepa, Thompson, Anthony W, Tyhonas, John S, Boehm, Marcus F

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Design, synthesis and structure–activity relationship of novel RXR-selective modulators von Michellys, Pierre-Yves, D'Arrigo, Jennifer, Grese, Timothy A., Karanewsky, Donald S., Leibowitz, Mark D., Mais, Dale A., Mapes, Christopher M., Reifel-Miller, Anne, Rungta, Deepa, Boehm, Marcus F.

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Cloning and expression of goldfish opsin sequences von Johnson, Randy L, Grant, Kathryn B, Zankel, Todd C, Boehm, Marcus F, Merbs, Shannath L, Nathans, Jeremy, Nakanishi, Koji

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Orally Active Purine-Based Inhibitors of the Heat Shock Protein 90 von Biamonte, Marco A, Shi, Jiandong, Hong, Kevin, Hurst, David C, Zhang, Lin, Fan, Junhua, Busch, David J, Karjian, Patricia L, Maldonado, Angelica A, Sensintaffar, John L, Yang, Yong-Ching, Kamal, Adeela, Lough, Rachel E, Lundgren, Karen, Burrows, Francis J, Timony, Gregg A, Boehm, Marcus F, Kasibhatla, Srinivas R

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Synthesis and Biological Evaluation of a New Class of Geldanamycin Derivatives as Potent Inhibitors of Hsp90 von Le Brazidec, Jean-Yves, Kamal, Adeela, Busch, David, Thao, Lia, Zhang, Lin, Timony, Gregg, Grecko, Roy, Trent, Katy, Lough, Rachel, Salazar, Tim, Khan, Samina, Burrows, Francis, Boehm, Marcus F

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Biological Characterization of a Heterodimer-Selective Retinoid X Receptor Modulator: Potential Benefits for the Treatment of Type 2 Diabetes von Leibowitz, Mark D, Ardecky, Robert J, Boehm, Marcus F, Broderick, Carol L, Carfagna, Mark A, Crombie, Diane L, D’Arrigo, Jennifer, Etgen, Garrett J, Faul, Margaret M, Grese, Timothy A, Havel, Henry, Hein, Nancy I, Heyman, Richard A, Jolley, Diane, Klausing, Kay, Liu, Sha, Mais, Dale E, Mapes, Christopher M, Marschke, Keith B, Michellys, Pierre-Yves, Montrose-Rafizadeh, Chahrzad, Ogilvie, Kathleen M, Pascual, Bernadette, Rungta, Deepa, Tyhonas, John S, Urcan, Mary S, Wardlow, Marilyn, Yumibe, Nathan, Reifel-Miller, Anne

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Syntheses of High Specific Activity 2,3- and 3,4-[3H]2-9-cis-Retinoic Acid von Bennani, Youssef L, Boehm, Marcus F

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Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells von Boehm, Marcus F, Zhang, Lin, Zhi, Lin, McClurg, Michael R, Berger, Elain, Wagoner, Murriel, Mais, Dale E, Suto, Carla M, Davies, Peter J. A, Heyman, Richard A, Nadzan, Alex M

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Activation of mammalian retinoid X receptors by the insect growth regulator methoprene von Harmon, M A, Boehm, M F, Heyman, R A, Mangelsdorf, D J

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