Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion von Leone, Robert D, Zhao, Liang, Englert, Judson M, Sun, Im-Meng, Oh, Min-Hee, Sun, Im-Hong, Arwood, Matthew L, Bettencourt, Ian A, Patel, Chirag H, Wen, Jiayu, Tam, Ada, Blosser, Richard L, Prchalova, Eva, Alt, Jesse, Rais, Rana, Slusher, Barbara S, Powell, Jonathan D

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Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells von Kim, KiBem, Skora, Andrew D., Li, Zhaobo, Liu, Qiang, Tam, Ada J., Blosser, Richard L., Diaz, Luis A., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin

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The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints von Llosa, Nicolas J, Cruise, Michael, Tam, Ada, Wicks, Elizabeth C, Hechenbleikner, Elizabeth M, Taube, Janis M, Blosser, Richard L, Fan, Hongni, Wang, Hao, Luber, Brandon S, Zhang, Ming, Papadopoulos, Nickolas, Kinzler, Kenneth W, Vogelstein, Bert, Sears, Cynthia L, Anders, Robert A, Pardoll, Drew M, Housseau, Franck

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Compartmental Analysis of T-cell Clonal Dynamics as a Function of Pathologic Response to Neoadjuvant PD-1 Blockade in Resectable Non-Small Cell Lung Cancer von Zhang, Jiajia, Ji, Zhicheng, Caushi, Justina X., El Asmar, Margueritta, Anagnostou, Valsamo, Cottrell, Tricia R., Chan, Hok Yee, Suri, Prerna, Guo, Haidan, Merghoub, Taha, Chaft, Jamie E., Reuss, Joshua E., Tam, Ada J., Blosser, Richard L., Abu-Akeel, Mohsen, Sidhom, John-William, Zhao, Ni, Ha, Jinny S., Jones, David R., Marrone, Kristen A., Naidoo, Jarushka, Gabrielson, Edward, Taube, Janis M., Velculescu, Victor E., Brahmer, Julie R., Housseau, Franck, Hellmann, Matthew D., Forde, Patrick M., Pardoll, Drew M., Ji, Hongkai, Smith, Kellie N.

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STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients von Vasquez-Dunddel, David, Pan, Fan, Zeng, Qi, Gorbounov, Mikhail, Albesiano, Emilia, Fu, Juan, Blosser, Richard L, Tam, Ada J, Bruno, Tullia, Zhang, Hao, Pardoll, Drew, Kim, Young

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Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells von Oh, Min-Hee, Sun, Im-Hong, Zhao, Liang, Leone, Robert D., Sun, Im-Meng, Xu, Wei, Collins, Samuel L., Tam, Ada J., Blosser, Richard L., Patel, Chirag H., Englert, Judson M., Arwood, Matthew L., Wen, Jiayu, Chan-Li, Yee, Tenora, Lukas, Majer, Pavel, Rais, Rana, Slusher, Barbara S., Horton, Maureen R., Powell, Jonathan D.

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Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8+ T cell differentiation von Pollizzi, Kristen N, Sun, Im-Hong, Patel, Chirag H, Lo, Ying-Chun, Oh, Min-Hee, Waickman, Adam T, Tam, Ada J, Blosser, Richard L, Wen, Jiayu, Delgoffe, Greg M, Powell, Jonathan D

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The Immunosuppressive Niche of Soft-Tissue Sarcomas is Sustained by Tumor-Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures von Chen, Lingling, Oke, Teniola, Siegel, Nicholas, Cojocaru, Gady, Tam, Ada J., Blosser, Richard L., Swailes, Jessica, Ligon, John A., Lebid, Andriana, Morris, Carol, Levin, Adam, Rhee, Daniel S., Johnston, Fabian M., Greer, Jonathan B., Meyer, Christian F., Ladle, Brian H., Thompson, Elizabeth D., Montgomery, Elizabeth A., Choi, Woonyoung, McConkey, David J., Anders, Robert A., Pardoll, Drew M., Llosa, Nicolas J.

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mTOR Complex 1 Signaling Regulates the Generation and Function of Central and Effector Foxp3 + Regulatory T Cells von Sun, Im-Hong, Oh, Min-Hee, Zhao, Liang, Patel, Chirag H, Arwood, Matthew L, Xu, Wei, Tam, Ada J, Blosser, Richard L, Wen, Jiayu, Powell, Jonathan D

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GOT1 constrains TH17 cell differentiation, while promoting iTreg cell differentiation von Xu, Wei, Patel, Chirag H., Alt, Jesse, Zhao, Liang, Sun, Im-Hong, Oh, Min-Hee, Sun, Im-Meng, Wen, Jiayu, Blosser, Richard L., Tam, Ada J., Powell, Jonathan D.

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Cutting Edge: mTORC2 Regulates CD8 + Effector and Memory T Cell Differentiation through Serum and Glucocorticoid Kinase 1 von Patel, Chirag H, Heikamp, Emily B, Xu, Wei, Sun, Im-Hong, Oh, Min-Hee, Sun, Im-Meng, Wen, Jiayu, Tam, Ada J, Blosser, Richard L, Powell, Jonathan D

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Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes von Skora, Andrew D., Douglass, Jacqueline, Hwang, Michael S., Tam, Ada J., Blosser, Richard L., Gabelli, Sandra B., Cao, Jianhong, Diaz, Luis A., Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Zhou, Shibin

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Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors von Shaikh, Fyza Y., Gills, Joell J., Mohammad, Fuad, White, James R., Stevens, Courtney M., Ding, Hua, Fu, Juan, Tam, Ada, Blosser, Richard L., Domingue, Jada C., Larman, Tatianna C., Chaft, Jamie E., Spicer, Jonathan D., Reuss, Joshua E., Naidoo, Jarushka, Forde, Patrick M., Ganguly, Sudipto, Housseau, Franck, Pardoll, Drew M., Sears, Cynthia L.

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Pathways of immune exclusion in metastatic osteosarcoma are associated with inferior patient outcomes von Ligon, John A, Choi, Woonyoung, Cojocaru, Gady, Fu, Wei, Hsiue, Emily Han-Chung, Oke, Teniola F, Siegel, Nicholas, Fong, Megan H, Ladle, Brian, Pratilas, Christine A, Morris, Carol D, Levin, Adam, Rhee, Daniel S, Meyer, Christian F, Tam, Ada J, Blosser, Richard, Thompson, Elizabeth D, Suru, Aditya, McConkey, David, Housseau, Franck, Anders, Robert, Pardoll, Drew M, Llosa, Nicolas

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High-dimensional Cytometry (ExCYT) and Mass Spectrometry of Myeloid Infiltrate in Clinically Localized Clear Cell Renal Cell Carcinoma Identifies Novel Potential Myeloid Targets fo... von Theodros, Debebe, Murter, Benjamin M., Sidhom, John-William, Nirschl, Thomas R., Clark, David J., Chen, LiJun, Tam, Ada J., Blosser, Richard L., Schwen, Zeyad R., Johnson, Michael H., Pierorazio, Phillip M., Zhang, Hui, Ganguly, Sudipto, Pardoll, Drew M., Zarif, Jelani C.

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Biomaterials direct functional B cell response in a material-specific manner von Moore, Erika M., Maestas, David R., Cherry, Chris C., Garcia, Jordan A., Comeau, Hannah Y., Huyer, Locke Davenport, Kelly, Sean H., Pena, Alexis N., Blosser, Richard L., Rosson, Gedge D., Elisseeff, Jennifer H.

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836 Murine fecal microbiota transfer models colonize human microbes selectively and reveal transcriptional pathways associated with response to neoadjuvant checkpoint inhibitors von Shaikh, Fyza, Gills, Joell, Mohammad, Fuad, White, James, Stevens, Courtney, Ding, Hua, Fu, Juan, Tam, Ada, Blosser, Richard, Larman, Tatianna, Naidoo, Jarushka, Forde, Patrick, Ganguly, Sudipto, Housseau, Franck, Pardoll, Drew, Sears, Cynthia

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Papillomavirus-Like Particles Stimulate Murine Bone Marrow-Derived Dendritic Cells To Produce Alpha Interferon and Th1 Immune Responses via MyD88 von RONGCUN YANG, MARTINEZ MURILLO, Francisco, HENGMI CUI, BLOSSER, Richard, UEMATSU, Satoshi, TAKEDA, Kiyoshi, AKIRA, Shizuo, VISCIDI, Raphael P, RODEN, Richard B. S

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Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers von Caushi, Justina X., Zhang, Jiajia, Ji, Zhicheng, Vaghasia, Ajay, Zhang, Boyang, Hsiue, Emily Han-Chung, Mog, Brian J., Hou, Wenpin, Justesen, Sune, Blosser, Richard, Tam, Ada, Anagnostou, Valsamo, Cottrell, Tricia R., Guo, Haidan, Chan, Hok Yee, Singh, Dipika, Thapa, Sampriti, Dykema, Arbor G., Burman, Poromendro, Choudhury, Begum, Aparicio, Luis, Cheung, Laurene S., Lanis, Mara, Belcaid, Zineb, El Asmar, Margueritta, Illei, Peter B., Wang, Rulin, Meyers, Jennifer, Schuebel, Kornel, Gupta, Anuj, Skaist, Alyza, Wheelan, Sarah, Naidoo, Jarushka, Marrone, Kristen A., Brock, Malcolm, Ha, Jinny, Bush, Errol L., Park, Bernard J., Bott, Matthew, Jones, David R., Reuss, Joshua E., Velculescu, Victor E., Chaft, Jamie E., Kinzler, Kenneth W., Zhou, Shibin, Vogelstein, Bert, Taube, Janis M., Hellmann, Matthew D., Brahmer, Julie R., Merghoub, Taha, Forde, Patrick M., Yegnasubramanian, Srinivasan, Ji, Hongkai, Pardoll, Drew M., Smith, Kellie N.

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mTORC2 regulates CD8+ effector and memory T cell differentiation through serum and glucocorticoid kinase 1 (SGK1) von Patel, Chirag H., Heikamp, Emily B., Xu, Wei, Sun, Im-Hong, Oh, Min-Hee, Sun, Im-Meng, Wen, Jiayu, Tam, Ada J., Blosser, Richard L., Powell, Jonathan D.

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