Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic von Reddy, Joseph A., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Kleindl, Paul, Santhapuram, Hari, Vlahov, Iontcho R., Leamon, Christopher P.

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High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide von Guertin, Amy D, O'Neil, Jennifer, Stoeck, Alexander, Reddy, Joseph A, Cristescu, Razvan, Haines, Brian B, Hinton, Marlene C, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Vetzel, Marilynn, Lejnine, Serguei, Nebozhyn, Michael, Zhang, Theresa, Loboda, Andrey, Picard, Kristen L, Schmidt, Emmett V, Dussault, Isabelle, Leamon, Christopher P

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Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate von Leamon, Christopher P, Reddy, Joseph A, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Vetzel, Marilynn, Kleindl, Paul, Hahn, Spencer, Wang, Kevin, Vlahov, Iontcho R

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Rational Combination Therapy of Vintafolide (EC145) with Commonly Used Chemotherapeutic Drugs von REDDY, Joseph A, DORTON, Ryan, BLOOMFIELD, Alicia, NELSON, Melissa, VETZEL, Marilynn, GUAN, John, LEAMON, Christopher P

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Folate–Vinca Alkaloid Conjugates for Cancer Therapy: A Structure–Activity Relationship von Leamon, Christopher P, Vlahov, Iontcho R, Reddy, Joseph A, Vetzel, Marilynn, Santhapuram, Hari Krishna R, You, Fei, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Kleindl, Paul, Vaughn, Jeremy F, Westrick, Elaine

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Abstract 5359: Antitumor efficacy of EC1456 in patient derived xenograft models of ovarian, endometrial, NSCLC and TNBC von Reddy, Joseph A., Bloomfield, Alicia, Taylor, Christina, Hargett, Katherine, Nelson, Melissa, Leamon, Christopher

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Abstract 832: Pre-clinical development of EC1456: A potent Folate targeted Tubulysin SMDC von Reddy, Joseph A., Bloomfield, Alicia, Nelson, Melissa, Dorton, Ryan, Vetzel, Marilynn, Leamon, Christopher P.

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Enhancing the therapeutic range of a targeted small-molecule tubulysin conjugate for folate receptor-based cancer therapy von Leamon, Christopher P., Reddy, Joseph A., Vlahov, Iontcho R., Dorton, Ryan, Bloomfield, Alicia, Vetzel, Marilynn, Klein, Patrick J., Westrick, Elaine, Xu, Le-cun, Wang, Yu

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Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications von Leamon, Christopher P, Reddy, Joseph A, Klein, Patrick J, Vlahov, Iontcho R, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Westrick, Elaine, Parker, Nikki, Bruna, Kristen, Vetzel, Marilynn, Gehrke, Mark, Nicoson, Jeffrey S, Messmann, Richard A, LoRusso, Patricia M, Sausville, Edward A

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Abstract 2145: PSMA-specific anti-tumor activity of the targeted-tubulysin conjugate, EC1169 von Reddy, Joseph A., Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Vetzel, Marilynn, Hahn, Spencer, Vlahov, Iontcho, Leamon, Christopher

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Abstract 782: Development of folate receptor positive drug-resistant cell lines and strategies to overcome drug resistance von Reddy, Joseph A., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Leamon, Christopher

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Abstract B65: High levels of expression of P-glycoprotein/multidrug resistance protein result in resistance to vintafolide von Guertin, Amy D., O'Neil, Jennifer, Stoeck, Alexander, Reddy, Joseph A., Cristescu, Razvan, Haines, Brian B., Hinton, Marlene C., Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Vetzel, Marilynn, Lejnine, Serguei, Nebozhyn, Michael, Zhang, Theresa, Loboda, Andrey, Picard, Kristen L., Schmidt, Emmett V., Dussault, Isabelle, Leamon, Christopher P.

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Abstract 3622: Predicting response to EC145 therapy using the folate receptor-specific radiodiagnostic imaging agent, 99mTc-EC20 von Leamon, Christopher P., Reddy, Joseph A., Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Klein, Patrick J., Vlahov, Iontcho R., Vetzel, Marilynn

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Abstract 2570: Combination studies of EC145 with approved anti-cancer drugs for ovarian cancer von Reddy, Joseph A., Bloomfield, Alicia, Nelson, Melissa, Dorton, Ryan, Leamon, Christopher P.

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Abstract 2518: Structure-activity relationships of folate-vinca alkaloid conjugates von Leamon, Christopher P., Vlahov, Iontcho R., Reddy, Joseph A., Vetzel, Marilynn, Santhapuram, Hari K., You, Fei, Bloomfield, Alicia, Dorton, Ryan, Nelson, Melissa, Kleindl, Paul, Vaughn, Jeremy, Westrick, Elaine

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Abstract 3248: PSMA specific imaging of prostate cancer von Reddy, Joseph A., Xu, Le-Cun, Dorton, Ryan, Bloomfield, Alicia, Nelson, Melissa, Klein, Patrick, Kularatne, Sumith, Low, Philip, Leamon, Christopher

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Abstract 4414: EC0531: A potent folate-targeted tubulysin conjugate von Leamon, Christopher P., Reddy, Joseph A., Wang, Yu, Dorton, Ryan, Westrick, Elaine, Bloomfield, Alicia, Vetzel, Marilynn, Klein, Patrick J., Vlahov, Iontcho R.

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Strategy to Prevent Drug-Related Hypersensitivity in Folate-Targeted Hapten Immunotherapy of Cancer von Lu, Yingjuan, Klein, Patrick J., Westrick, Elaine, Xu, Le-Cun, Santhapuram, Hari Krishna R., Bloomfield, Alicia, Howard, Stephen J., Vlahov, Iontcho R., Ellis, P. Ron, Low, Philip S., Leamon, Christopher P.

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Conjugates for treating diseases caused by PSMA expressing cells von REDDY, Joseph Anand, NELSON, Melissa, VLAHOV, Iontcho Radoslavov, BLOOMFIELD, Alicia, DORTON, Ryan, VETZEL, Marilynn, LEAMON, Christopher Paul

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Conjugates for treating diseases caused by PSMA expressing cells von Vetzel, Marilynn, Dorton, Ryan, Nelson, Melissa, Leamon, Christopher Paul, Vlahov, Iontcho Radoslavov, Reddy, Joseph Anand, Bloomfield, Alicia

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