Antibody-mediated phagocytosis contributes to the anti-tumor activity of the therapeutic antibody daratumumab in lymphoma and multiple myeloma von Overdijk, Marije B, Verploegen, Sandra, Bögels, Marijn, van Egmond, Marjolein, van Bueren, Jeroen J Lammerts, Mutis, Tuna, Groen, Richard WJ, Breij, Esther, Martens, Anton CM, Bleeker, Wim K, Parren, Paul WHI

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Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques von Hessell, Ann J, Poignard, Pascal, Hunter, Meredith, Hangartner, Lars, Tehrani, David M, Bleeker, Wim K, Parren, Paul W H I, Marx, Preston A, Burton, Dennis R

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Daratumumab, a novel therapeutic human CD38 monoclonal antibody, induces killing of multiple myeloma and other hematological tumors von de Weers, Michel, Tai, Yu-Tzu, van der Veer, Michael S, Bakker, Joost M, Vink, Tom, Jacobs, Daniëlle C H, Oomen, Lukas A, Peipp, Matthias, Valerius, Thomas, Slootstra, Jerry W, Mutis, Tuna, Bleeker, Wim K, Anderson, Kenneth C, Lokhorst, Henk M, van de Winkel, Jan G J, Parren, Paul W H I

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Crosstalk between human IgG isotypes and murine effector cells von Overdijk, Marije B, Verploegen, Sandra, Ortiz Buijsse, Antonio, Vink, Tom, Leusen, Jeanette H W, Bleeker, Wim K, Parren, Paul W H I

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Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange von van der Neut Kolfschoten, Marijn, Schuurman, Janine, Losen, Mario, Bleeker, Wim K., Martínez-Martínez, Pilar, Vermeulen, Ellen, Bleker, Tamara H. den, Wiegman, Luus, Vink, Tom, Aarden, Lucien A., De Baets, Marc H., van de Winkel, Jan G. J., Aalberse, Rob C., Parren, Paul W. H. I.

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High turnover of tissue factor enables efficient intracellular delivery of antibody-drug conjugates von de Goeij, Bart E C G, Satijn, David, Freitag, Claudia M, Wubbolts, Richard, Bleeker, Wim K, Khasanov, Alisher, Zhu, Tong, Chen, Gary, Miao, David, van Berkel, Patrick H C, Parren, Paul W H I

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Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells von Peipp, Matthias, Lammerts van Bueren, Jeroen J., Schneider-Merck, Tanja, Bleeker, Wim W.K., Dechant, Michael, Beyer, Thomas, Repp, Roland, van Berkel, Patrick H.C., Vink, Tom, van de Winkel, Jan G.J., Parren, Paul W.H.I., Valerius, Thomas

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Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Linea... von Schneider-Merck, Tanja, Lammerts van Bueren, Jeroen J, Berger, Sven, Rossen, Kai, van Berkel, Patrick H.C, Derer, Stefanie, Beyer, Thomas, Lohse, Stefan, Bleeker, Wim K, Peipp, Matthias, Parren, Paul W. H. I, van de Winkel, Jan G. J, Valerius, Thomas, Dechant, Michael

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IgA EGFR antibodies mediate tumour killing in vivo von Boross, Peter, Lohse, Stefan, Nederend, Maaike, Jansen, Johannes Hendrik Marco, van Tetering, Geert, Dechant, Michael, Peipp, Matthias, Royle, Louise, Liew, Li Phing, Boon, Louis, van Rooijen, Nico, Bleeker, Wim K., Parren, Paul W. H. I., van de Winkel, Jan G. J., Valerius, Thomas, Leusen, Jeanette H. W.

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Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies von DECHANT, Michael, WEISNER, Wencke, VALERIUS, Thomas, BERGER, Sven, PEIPP, Matthias, BEYER, Thomas, SCHNEIDER-MERCK, Tanja, LAMMERTS VAN BUEREN, Jeroen J, BLEEKER, Wim K, PARREN, Paul W. H. I, VAN DE WINKEL, Jan G. J

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Effect of target dynamics on pharmacokinetics of a novel therapeutic antibody against the epidermal growth factor receptor : Implications for the mechanisms of action von LAMMERTS VAN BUEREN, Jeroen J, BLEEKER, Wim K, BOGH, Henrik O, HOUTKAMP, Mischa, SCHUURMAN, Janine, VAN DE WINKEL, Jan G. J, PARREN, Paul W. H. I

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Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti‐CD20 antibody von Bleeker, Wim K., Munk, Martin E., Mackus, Wendy J. M., Van Den Brakel, Jeroen H. N., Pluyter, Marielle, Glennie, Martin J., Van De Winkel, Jan G. J., Parren, Paul W. H. I.

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Dual Mode of Action of a Human Anti-Epidermal Growth Factor Receptor Monoclonal Antibody for Cancer Therapy von Bleeker, Wim K, Lammerts van Bueren, Jeroen J, van Ojik, Heidi H, Gerritsen, Arnout F, Pluyter, Marielle, Houtkamp, Mischa, Halk, Ed, Goldstein, Joel, Schuurman, Janine, van Dijk, Marc A, van de Winkel, Jan G. J, Parren, Paul W. H. I

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An Antibody-Drug Conjugate That Targets Tissue Factor Exhibits Potent Therapeutic Activity against a Broad Range of Solid Tumors von BREIJ, Esther C. W, DE GOEIJ, Bart E. C. G, PARREN, Paul W. H. I, VERPLOEGEN, Sandra, SCHUURHUIS, Danita H, AMIRKHOSRAVI, Ali, FRANCIS, John, MILLER, Vibeke Breinholt, HOUTKAMP, Mischa, BLEEKER, Wim K, SATIJN, David

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Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia von Teeling, Jessica L., Jansen-Hendriks, Theo, Kuijpers, Taco W., de Haas, Masja, van de Winkel, Jan G.J., Hack, C. Erik, Bleeker, Wim K.

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antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility von Lammerts van Bueren, Jeroen J, Bleeker, Wim K, Brännström, Annika, von Euler, Anne, Jansson, Magnus, Peipp, Matthias, Schneider-Merck, Tanja, Valerius, Thomas, van de Winkel, Jan G.J, Parren, Paul W.H.I

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Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo von Labrijn, Aran F, Buijsse, Antonio Ortiz, van den Bremer, Ewald T J, Verwilligen, Annemiek Y W, Bleeker, Wim K, Thorpe, Susan J, Killestein, Joep, Polman, Chris H, Aalberse, Rob C, Schuurman, Janine, van de Winkel, Jan G J, Parren, Paul W H I

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Late B cell depletion with a human anti-human CD20 IgG1κ monoclonal antibody halts the development of experimental autoimmune encephalomyelitis in marmosets von Kap, Yolanda S, van Driel, Nikki, Blezer, Erwin, Parren, Paul W H I, Bleeker, Wim K, Laman, Jon D, Craigen, Jenny L, 't Hart, Bert A

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Epidermal growth factor receptor (EGFR) antibody-induced antibody-dependent cellular cytotoxicity plays a prominent role in inhibiting tumorigenesis, even of tumor cells insensitiv... von Overdijk, Marije B, Verploegen, Sandra, van den Brakel, Jeroen H, Lammerts van Bueren, Jeroen J, Vink, Tom, van de Winkel, Jan G J, Parren, Paul W H I, Bleeker, Wim K

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Targeted multi-pinhole SPECT von Branderhorst, Woutjan, Vastenhouw, Brendan, van der Have, Frans, Blezer, Erwin L. A., Bleeker, Wim K., Beekman, Freek J.

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