Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models von Zenke, Frank T., Zimmermann, Astrid, Sirrenberg, Christian, Dahmen, Heike, Kirkin, Vladimir, Pehl, Ulrich, Grombacher, Thomas, Wilm, Claudia, Fuchss, Thomas, Amendt, Christiane, Vassilev, Lyubomir T., Blaukat, Andree

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DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia von Haines, Eric, Nishida, Yuki, Carr, Michael I., Montoya, Rafael Heinz, Ostermann, Lauren B., Zhang, Weiguo, Zenke, Frank T., Blaukat, Andree, Andreeff, Michael, Vassilev, Lyubomir T.

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Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814 von Sun, Qing, Guo, Yige, Liu, Xiaohong, Czauderna, Frank, Carr, Michael I, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T

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A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies von Zimmermann, Astrid, Zenke, Frank T, Chiu, Li-Ya, Dahmen, Heike, Pehl, Ulrich, Fuchss, Thomas, Grombacher, Thomas, Blume, Beatrix, Vassilev, Lyubomir T, Blaukat, Andree

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Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation von Klein, Carmen, Dokic, Ivana, Mairani, Andrea, Mein, Stewart, Brons, Stephan, Häring, Peter, Haberer, Thomas, Jäkel, Oliver, Zimmermann, Astrid, Zenke, Frank, Blaukat, Andree, Debus, Jürgen, Abdollahi, Amir

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Matuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for Dimerization von Schmiedel, Judith, Blaukat, Andree, Li, Shiqing, Knöchel, Thorsten, Ferguson, Kathryn M.

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DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia von Carr, Michael, Zimmermann, Astrid, Chiu, Li-Ya, Zenke, Frank T., Blaukat, Andree, Vassilev, Lyubomir T.

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Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy von Zenke, Frank T., Zimmermann, Astrid, Dahmen, Heike, Elenbaas, Brian, Pollard, John, Reaper, Philip, Bagrodia, S, Spilker, M E., Amendt, C, Blaukat, Andree

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Deciphering MET‐dependent modulation of global cellular responses to DNA damage by quantitative phosphoproteomics von Bensimon, Ariel, Koch, Jonas P., Francica, Paola, Roth, Selina M., Riedo, Rahel, Glück, Astrid A., Orlando, Eleonora, Blaukat, Andree, Aebersold, Daniel M., Zimmer, Yitzhak, Aebersold, Ruedi, Medová, Michaela

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Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells von Humbert, Magali, Medová, Michaela, Aebersold, Daniel M., Blaukat, Andree, Bladt, Friedhelm, Fey, Martin F., Zimmer, Yitzhak, Tschan, Mario P.

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Phosphorylation and regulation of a G protein-coupled receptor by protein kinase CK2 von Torrecilla, Ignacio, Spragg, Elizabeth J, Poulin, Benoit, McWilliams, Phillip J, Mistry, Sharad C, Blaukat, Andree, Tobin, Andrew B

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Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells von Bu, Shizhong, Blaukat, Andree, Fu, Xin, Heldin, Nils-Erik, Landström, Maréne

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The Tyrosine Kinase Pyk2 Regulates Arf1 Activity by Phosphorylation and Inhibition of the Arf-GTPase-activating Protein ASAP1 von Kruljac-Letunic, Anamarija, Moelleken, Jörg, Kallin, Anders, Wieland, Felix, Blaukat, Andree

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Prediction of active human dose: learnings from 20 years of Merck KGaA experience, illustrated by case studies von Peters, Sheila Annie, Petersson, Carl, Blaukat, Andree, Halle, Joern-Peter, Dolgos, Hugues

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Determination of Bradykinin B2 Receptor in Vivo Phosphorylation Sites and Their Role in Receptor Function von Blaukat, Andree, Pizard, Anne, Breit, Andreas, Wernstedt, Christer, Alhenc-Gelas, François, Müller-Esterl, Werner, Dikic, Ivan

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Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63 von Niedernberg, Anke, Tunaru, Sorin, Blaukat, Andree, Ardati, Ali, Kostenis, Evi

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Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors von Turchick, Audrey, Zimmermann, Astrid, Chiu, Li-Ya, Dahmen, Heike, Elenbaas, Brian, Zenke, Frank T, Blaukat, Andree, Vassilev, Lyubomir T

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Abstract 2591: Activity of MSC2156119J in non-small cell lung cancer models with activating EGFR mutation von Bladt, Friedhelm, Friese-Hamim, Manja, Blaukat, Andree

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Abstract 4853: M6123 is an ADCC-enhanced and selective monovalent antagonist of FGFR1 showing antitumor activity in preclinical lung cancer models von Esdar, Christina, Iffland, Christel, Zimmermann, Astrid, Lim, Angela, Sanderson, Michael, Blaukat, Andree

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Abstract 3774: Unraveling mechanisms of resistance to tepotinib and future treatment options von Pudelko, Linda, Jaehrling, Frank, Stroh, Christopher, Linde, Nina, Sanderson, Michael, Musch, Doreen, Keil, Marina, Esdar, Christina, Blaukat, Andree, Karachaliou, Niki

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