Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1 von Blasina, Alessandra, Hallin, Jill, Chen, Enhong, Arango, Maria Elena, Kraynov, Eugenia, Register, James, Grant, Stephan, Ninkovic, Sacha, Chen, Ping, Nichols, Tim, O'Connor, Patrick, Anderes, Kenna

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Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer von Kung, Pei-Pei, Martinez, Ricardo, Zhu, Zhou, Zager, Michael, Blasina, Alessandra, Rymer, Isha, Hallin, Jill, Xu, Meirong, Carroll, Christopher, Chionis, John, Wells, Peter, Kozminski, Kirk, Fan, Jeffery, Guicherit, Oivin, Huang, Buwen, Cui, Mei, Liu, Chaoting, Huang, Zhongdong, Sistla, Anand, Yang, Jennifer, Murray, Brion W

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ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine von Heffernan, Timothy P., Kawasumi, Masaoki, Blasina, Alessandra, Anderes, Kenna, Conney, Allan H., Nghiem, Paul

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Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility von Martinez, Ricardo, Blasina, Alessandra, Hallin, Jill F, Hu, Wenyue, Rymer, Isha, Fan, Jeffery, Hoffman, Robert L, Murphy, Sean, Marx, Matthew, Yanochko, Gina, Trajkovic, Dusko, Dinh, Dac, Timofeevski, Sergei, Zhu, Zhou, Sun, Peiquing, Lappin, Patrick B, Murray, Brion W

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Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1 von McGowan, Clare H, Melchionna, Roberta, Chen, Xiao-Bo, Blasina, Alessandra

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Human Mus81-Associated Endonuclease Cleaves Holliday Junctions In Vitro von Chen, Xiao-Bo, Melchionna, Roberta, Denis, Cecile-Marie, Gaillard, Pierre-Henri L., Blasina, Alessandra, Van de Weyer, Inez, Boddy, Michael N., Russell, Paul, Vialard, Jorge, McGowan, Clare H.

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase von Blasina, Alessandra, de Weyer, Inez Van, Laus, Marc C., Luyten, Walter H.M.L., Parker, Andrew E., McGowan, Clare H.

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Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1 von Furnari, B, Blasina, A, Boddy, M N, McGowan, C H, Russell, P

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PF-04691502, a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity von Yuan, Jing, Mehta, Pramod P, Yin, Min-Jean, Sun, Shaoxian, Zou, Aihua, Chen, Jeffrey, Rafidi, Kristina, Feng, Zheng, Nickel, Jeffrey, Engebretsen, Jon, Hallin, Jill, Blasina, Alessandra, Zhang, Eric, Nguyen, Leslie, Sun, Minghao, Vogt, Peter K, McHarg, Aileen, Cheng, Hengmiao, Christensen, James G, Kan, Julie L C, Bagrodia, Shubha

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Role of TrfA and DnaA Proteins in Origin Opening during Initiation of DNA Replication of the Broad Host Range Plasmid RK2 von Konieczny, Igor, Doran, Kelly S., Helinski, Donald R., Blasina, Alessandra

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Caffeine inhibits the checkpoint kinase ATM von Blasina, Alessandra, Price, Brendan D., Turenne, Gaetan A., McGowan, Clare H.

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Abstract 2549: Efficacy of the Chk1 inhibitor PF-00477736 and pemetrexed in human mesothelioma von Blasina, Alessandra, Hallin, Jill F., Tan, Wei, Los, Gerrit, Jani, Jitesh P.

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Abstract 3601: Evaluation of a mathematical modeling framework to describe combination therapy with Gemcitabine von Spilker, Mary E., Yamazaki, Shinji, Blasina, Alessandra, Hallin, Jill, Bartkowski, Darian M., Vicini, Paolo

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Structure-Based Design of (5-Arylamino-2H-pyrazol-3-yl)-biphenyl-2‘,4‘-diols as Novel and Potent Human CHK1 Inhibitors von Teng, Min, Zhu, Jinjiang, Johnson, Michael D, Chen, Ping, Kornmann, Jill, Chen, Enhong, Blasina, Alessandra, Register, James, Anderes, Kenna, Rogers, Caroline, Deng, Yali, Ninkovic, Sacha, Grant, Stephan, Hu, Qiyue, Lundgren, Karen, Peng, Zhengwei, Kania, Robert S

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ATR-Chk1 pathway inhibition promotes apoptosis after UV in primary human keratinocytes: potential basis for caffeine’s UV protective effects von Heffernan, Timothy P., Kawasumi, Masaoki, Blasina, Alessandra, Anderes, Kenna, Conney, Allan H., Nghiem, Paul

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cells enriched with tumor spheroids from a non-small cell lung cancer cell l... von Fang, Douglas D., Cao, Joan, Jani, Jitesh P., Tsaparikos, Konstantinos, Blasina, Alessandra, Kornmann, Jill, Lira, Maruja E., Wang, Jianying, Jirout, Zuzana, Bingham, Justin, Zhu, Zhou, Gu, Yin, Los, Gerrit, Hostomsky, Zdenek, VanArsdale, Todd

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The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells von Blasina, A, Paegle, E S, McGowan, C H

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Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors von Teng, Min, Zhu, Jinjiang, Johnson, Michael D, Chen, Ping, Kornmann, Jill, Chen, Enhong, Blasina, Alessandra, Register, James, Anderes, Kenna, Rogers, Caroline, Deng, Yali, Ninkovic, Sacha, Grant, Stephan, Hu, Qiyue, Lundgren, Karen, Peng, Zhengwei, Kania, Robert S

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Copy-Up Mutants of the Plasmid RK2 Replication Initiation Protein are Defective in Coupling RK2 Replication Origins von Blasina, Alessandra, Kittell, Barbara L., Toukdarian, Aresa E., Helinski, Donald R.

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COMBINATION THERAPY OF (2R,Z)-2-AMINO-2-CYCLOHEXYL-N-(5-(1-METHYL-1H-PYRAZOL-4-YL)-1-OXO-2,6-DIHYDRO-1H-[1,2]DIAZEPINO[4,5,6-CD]INDOL-8-YL)ACETAMIDE von BLASINA ALESSANDRA, ANDERES KENNA

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